Effects of Gmelina arborea Roxb. leaves on wound healing in rats

A. Shirwaikar, S. Ghosh, P.G.M. Rao

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: To study the effect of the alcoholic extract of the dried leaves powder of Gmelina arborea on wound healing. Materials and method: The alcoholic extract was studied at dose level of 200 mg/kg body weight using incision, excision and dead space wound models in rats. Results: Significant increase in wound contraction rate, skin breaking strength, granuloma breaking strength, hydroxyproline content and dry granuloma weight and decrease in epithelization period was observed. The prohealing actions seem to be due to increased collagen deposition as well as better alignment and maturation. Conclusion: From the results it may be concluded that the plant Gmelina arborea is endowed with significant wound healing activity, thereby justifying its use in the traditional medicine.
Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalJournal of Natural Remedies
Volume3
Issue number1
Publication statusPublished - 2003

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Granuloma
Wound Healing
Space Simulation
Hydroxyproline
Wounds and Injuries
Traditional Medicine
Powders
Collagen
Body Weight
Weights and Measures
Skin

Cite this

Shirwaikar, A., Ghosh, S., & Rao, P. G. M. (2003). Effects of Gmelina arborea Roxb. leaves on wound healing in rats. Journal of Natural Remedies, 3(1), 45-48.
Shirwaikar, A. ; Ghosh, S. ; Rao, P.G.M. / Effects of Gmelina arborea Roxb. leaves on wound healing in rats. In: Journal of Natural Remedies. 2003 ; Vol. 3, No. 1. pp. 45-48.
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abstract = "Objective: To study the effect of the alcoholic extract of the dried leaves powder of Gmelina arborea on wound healing. Materials and method: The alcoholic extract was studied at dose level of 200 mg/kg body weight using incision, excision and dead space wound models in rats. Results: Significant increase in wound contraction rate, skin breaking strength, granuloma breaking strength, hydroxyproline content and dry granuloma weight and decrease in epithelization period was observed. The prohealing actions seem to be due to increased collagen deposition as well as better alignment and maturation. Conclusion: From the results it may be concluded that the plant Gmelina arborea is endowed with significant wound healing activity, thereby justifying its use in the traditional medicine.",
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note = "Cited By :20 Export Date: 10 November 2017 CODEN: JNROA Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal 576 119 Dakshina, India; email: annie.shirwaikar@cops.manipal.edu Chemicals/CAS: alcohol, 64-17-5; collagen, 9007-34-5; hydroxyproline, 51-35-4, 6912-67-0 References: Satyavati, G.V., Raina, M.K., Sharma, M., (1976) Medicinal Plants of India, 1, pp. 441-444. , Indian Council of Medical Research: New Delhi; Chopra, R.N., Nayar, S.L., Chopra, I.C., (1986) Glossary of Indian Medicinal Plants, p. 126. , Publication and Information Directorate, CSIR: New Delhi; Dassanayake, M.D., Fosberg, F.R., Revised Handbook to The Flora of Ceylon, 4, pp. 388-394; Agrawal, V.K., Gambhir, S.S., Wahi, A.K., (1994) Indian J. Nat. Prod., 10 (1), pp. 14-15; Harborne, J.B., (1984) Phytochemical Methods, , 2nd edn Chapman and Hall: London; Kokate, C.K., (1991) Practical Pharmacognosy, pp. 107-121. , 3rd edn. Vallabh Prakashan: India; Ehrlich, H.P., Hunt, T.K., (1969) Ann. Surg., 170, p. 203; Lee, K.H., (1968) J. Pharmacol. Sci., 57, p. 1042; Morton, J.J.P., Malone, H.H., (1972) Arch. Int. Pharmacodyn. Ther., 196, p. 117; Neuman, R.E., Logan, M.A., (1950) J. Biol. Chem., 186, p. 83",
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Shirwaikar, A, Ghosh, S & Rao, PGM 2003, 'Effects of Gmelina arborea Roxb. leaves on wound healing in rats', Journal of Natural Remedies, vol. 3, no. 1, pp. 45-48.

Effects of Gmelina arborea Roxb. leaves on wound healing in rats. / Shirwaikar, A.; Ghosh, S.; Rao, P.G.M.

In: Journal of Natural Remedies, Vol. 3, No. 1, 2003, p. 45-48.

Research output: Contribution to journalArticle

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AU - Ghosh, S.

AU - Rao, P.G.M.

N1 - Cited By :20 Export Date: 10 November 2017 CODEN: JNROA Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal 576 119 Dakshina, India; email: annie.shirwaikar@cops.manipal.edu Chemicals/CAS: alcohol, 64-17-5; collagen, 9007-34-5; hydroxyproline, 51-35-4, 6912-67-0 References: Satyavati, G.V., Raina, M.K., Sharma, M., (1976) Medicinal Plants of India, 1, pp. 441-444. , Indian Council of Medical Research: New Delhi; Chopra, R.N., Nayar, S.L., Chopra, I.C., (1986) Glossary of Indian Medicinal Plants, p. 126. , Publication and Information Directorate, CSIR: New Delhi; Dassanayake, M.D., Fosberg, F.R., Revised Handbook to The Flora of Ceylon, 4, pp. 388-394; Agrawal, V.K., Gambhir, S.S., Wahi, A.K., (1994) Indian J. Nat. Prod., 10 (1), pp. 14-15; Harborne, J.B., (1984) Phytochemical Methods, , 2nd edn Chapman and Hall: London; Kokate, C.K., (1991) Practical Pharmacognosy, pp. 107-121. , 3rd edn. Vallabh Prakashan: India; Ehrlich, H.P., Hunt, T.K., (1969) Ann. Surg., 170, p. 203; Lee, K.H., (1968) J. Pharmacol. Sci., 57, p. 1042; Morton, J.J.P., Malone, H.H., (1972) Arch. Int. Pharmacodyn. Ther., 196, p. 117; Neuman, R.E., Logan, M.A., (1950) J. Biol. Chem., 186, p. 83

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N2 - Objective: To study the effect of the alcoholic extract of the dried leaves powder of Gmelina arborea on wound healing. Materials and method: The alcoholic extract was studied at dose level of 200 mg/kg body weight using incision, excision and dead space wound models in rats. Results: Significant increase in wound contraction rate, skin breaking strength, granuloma breaking strength, hydroxyproline content and dry granuloma weight and decrease in epithelization period was observed. The prohealing actions seem to be due to increased collagen deposition as well as better alignment and maturation. Conclusion: From the results it may be concluded that the plant Gmelina arborea is endowed with significant wound healing activity, thereby justifying its use in the traditional medicine.

AB - Objective: To study the effect of the alcoholic extract of the dried leaves powder of Gmelina arborea on wound healing. Materials and method: The alcoholic extract was studied at dose level of 200 mg/kg body weight using incision, excision and dead space wound models in rats. Results: Significant increase in wound contraction rate, skin breaking strength, granuloma breaking strength, hydroxyproline content and dry granuloma weight and decrease in epithelization period was observed. The prohealing actions seem to be due to increased collagen deposition as well as better alignment and maturation. Conclusion: From the results it may be concluded that the plant Gmelina arborea is endowed with significant wound healing activity, thereby justifying its use in the traditional medicine.

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JO - Journal of Natural Remedies

JF - Journal of Natural Remedies

SN - 0972-5547

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