Effects of iron status on pulmonary tuberculosis in response to directly observed treatment short course (dots)

A. Puneeth, Madan Gopal Rajan, Akshatha L. Naik, Anupama Hegde, Mamatha T. Shenoy, A. P. Shaheena, Poornima A. Manjrekar

Research output: Contribution to journalArticle

Abstract

Background: Among the many micronutrients, iron has a significant role in the pathogenesis of tuberculosis. The contribution of iron status to the underlying anemia of chronic disease and its effects on the outcome is difficult to assess. Objective of the study: To evaluate the effects of the iron status on pulmonary tuberculosis in response to directly observed treatment short course. Materials & methods: Non-Randomized controlled comparative prospective study was done, ninety newly diagnosed pulmonary tuberculosis cases were selected based on sputum smear positive & chest X-ray reports and were followed up till they completed the intensive phase of DOTS therapy. The patients were divided equally based on their baseline hemoglobin levels as anemic (males: 9 - 12g/dL; females: 8-11g/dL) and non-Anemic (males: >12g/dl; females: >11g/dl). The iron status was assessed by estimating serum iron profile and ferritin at baseline and after completion of intensive phase therapy.C- reactive protein (CRP) was also done. Results: Serum iron, TIBC, transferrin saturation, significantly increased (p < 0.001), followed by significant decrease in S. ferritin and CRP (p < 0.001) in both the groups at the end of intensive phase therapy. 15 cases tested sputum smear positive (10 in the anemic group, 5 in the non-Anemic group) at the end of follow-up period. Conclusion: At the end of intensive phase therapy, improvement of BMI, iron status and CRP was observed in both the groups to a similar extent without any iron supplementation. However, more people in the anemic group remained sputum smear-positive at the end of intensive phase of DOTS therapy indicating that co-existence of anemia was a hindrance to the outcome.

Original languageEnglish
Pages (from-to)15-21
Number of pages7
JournalBiomedicine (India)
Volume36
Issue number2
Publication statusPublished - 01-04-2016

Fingerprint

Pulmonary Tuberculosis
Iron
Sputum
C-Reactive Protein
Therapeutics
Ferritins
Anemia
Micronutrients
Transferrin
Serum
Hemoglobins
Tuberculosis
Chronic Disease
Thorax
X-Rays
Prospective Studies
X rays

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Puneeth, A. ; Rajan, Madan Gopal ; Naik, Akshatha L. ; Hegde, Anupama ; Shenoy, Mamatha T. ; Shaheena, A. P. ; Manjrekar, Poornima A. / Effects of iron status on pulmonary tuberculosis in response to directly observed treatment short course (dots). In: Biomedicine (India). 2016 ; Vol. 36, No. 2. pp. 15-21.
@article{e28ace2b308f4ea5ac01b9828c8fb38e,
title = "Effects of iron status on pulmonary tuberculosis in response to directly observed treatment short course (dots)",
abstract = "Background: Among the many micronutrients, iron has a significant role in the pathogenesis of tuberculosis. The contribution of iron status to the underlying anemia of chronic disease and its effects on the outcome is difficult to assess. Objective of the study: To evaluate the effects of the iron status on pulmonary tuberculosis in response to directly observed treatment short course. Materials & methods: Non-Randomized controlled comparative prospective study was done, ninety newly diagnosed pulmonary tuberculosis cases were selected based on sputum smear positive & chest X-ray reports and were followed up till they completed the intensive phase of DOTS therapy. The patients were divided equally based on their baseline hemoglobin levels as anemic (males: 9 - 12g/dL; females: 8-11g/dL) and non-Anemic (males: >12g/dl; females: >11g/dl). The iron status was assessed by estimating serum iron profile and ferritin at baseline and after completion of intensive phase therapy.C- reactive protein (CRP) was also done. Results: Serum iron, TIBC, transferrin saturation, significantly increased (p < 0.001), followed by significant decrease in S. ferritin and CRP (p < 0.001) in both the groups at the end of intensive phase therapy. 15 cases tested sputum smear positive (10 in the anemic group, 5 in the non-Anemic group) at the end of follow-up period. Conclusion: At the end of intensive phase therapy, improvement of BMI, iron status and CRP was observed in both the groups to a similar extent without any iron supplementation. However, more people in the anemic group remained sputum smear-positive at the end of intensive phase of DOTS therapy indicating that co-existence of anemia was a hindrance to the outcome.",
author = "A. Puneeth and Rajan, {Madan Gopal} and Naik, {Akshatha L.} and Anupama Hegde and Shenoy, {Mamatha T.} and Shaheena, {A. P.} and Manjrekar, {Poornima A.}",
year = "2016",
month = "4",
day = "1",
language = "English",
volume = "36",
pages = "15--21",
journal = "Biomedicine",
issn = "0970-2067",
publisher = "Indian Association of Biomedical Scientists",
number = "2",

}

Effects of iron status on pulmonary tuberculosis in response to directly observed treatment short course (dots). / Puneeth, A.; Rajan, Madan Gopal; Naik, Akshatha L.; Hegde, Anupama; Shenoy, Mamatha T.; Shaheena, A. P.; Manjrekar, Poornima A.

In: Biomedicine (India), Vol. 36, No. 2, 01.04.2016, p. 15-21.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of iron status on pulmonary tuberculosis in response to directly observed treatment short course (dots)

AU - Puneeth, A.

AU - Rajan, Madan Gopal

AU - Naik, Akshatha L.

AU - Hegde, Anupama

AU - Shenoy, Mamatha T.

AU - Shaheena, A. P.

AU - Manjrekar, Poornima A.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background: Among the many micronutrients, iron has a significant role in the pathogenesis of tuberculosis. The contribution of iron status to the underlying anemia of chronic disease and its effects on the outcome is difficult to assess. Objective of the study: To evaluate the effects of the iron status on pulmonary tuberculosis in response to directly observed treatment short course. Materials & methods: Non-Randomized controlled comparative prospective study was done, ninety newly diagnosed pulmonary tuberculosis cases were selected based on sputum smear positive & chest X-ray reports and were followed up till they completed the intensive phase of DOTS therapy. The patients were divided equally based on their baseline hemoglobin levels as anemic (males: 9 - 12g/dL; females: 8-11g/dL) and non-Anemic (males: >12g/dl; females: >11g/dl). The iron status was assessed by estimating serum iron profile and ferritin at baseline and after completion of intensive phase therapy.C- reactive protein (CRP) was also done. Results: Serum iron, TIBC, transferrin saturation, significantly increased (p < 0.001), followed by significant decrease in S. ferritin and CRP (p < 0.001) in both the groups at the end of intensive phase therapy. 15 cases tested sputum smear positive (10 in the anemic group, 5 in the non-Anemic group) at the end of follow-up period. Conclusion: At the end of intensive phase therapy, improvement of BMI, iron status and CRP was observed in both the groups to a similar extent without any iron supplementation. However, more people in the anemic group remained sputum smear-positive at the end of intensive phase of DOTS therapy indicating that co-existence of anemia was a hindrance to the outcome.

AB - Background: Among the many micronutrients, iron has a significant role in the pathogenesis of tuberculosis. The contribution of iron status to the underlying anemia of chronic disease and its effects on the outcome is difficult to assess. Objective of the study: To evaluate the effects of the iron status on pulmonary tuberculosis in response to directly observed treatment short course. Materials & methods: Non-Randomized controlled comparative prospective study was done, ninety newly diagnosed pulmonary tuberculosis cases were selected based on sputum smear positive & chest X-ray reports and were followed up till they completed the intensive phase of DOTS therapy. The patients were divided equally based on their baseline hemoglobin levels as anemic (males: 9 - 12g/dL; females: 8-11g/dL) and non-Anemic (males: >12g/dl; females: >11g/dl). The iron status was assessed by estimating serum iron profile and ferritin at baseline and after completion of intensive phase therapy.C- reactive protein (CRP) was also done. Results: Serum iron, TIBC, transferrin saturation, significantly increased (p < 0.001), followed by significant decrease in S. ferritin and CRP (p < 0.001) in both the groups at the end of intensive phase therapy. 15 cases tested sputum smear positive (10 in the anemic group, 5 in the non-Anemic group) at the end of follow-up period. Conclusion: At the end of intensive phase therapy, improvement of BMI, iron status and CRP was observed in both the groups to a similar extent without any iron supplementation. However, more people in the anemic group remained sputum smear-positive at the end of intensive phase of DOTS therapy indicating that co-existence of anemia was a hindrance to the outcome.

UR - http://www.scopus.com/inward/record.url?scp=85027962242&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027962242&partnerID=8YFLogxK

M3 - Article

VL - 36

SP - 15

EP - 21

JO - Biomedicine

JF - Biomedicine

SN - 0970-2067

IS - 2

ER -