Effects of iron status on pulmonary tuberculosis in response to directly observed treatment short course (dots)

A. Puneeth, Madan Gopal Rajan, Akshatha L. Naik, Anupama Hegde, Mamatha T. Shenoy, A. P. Shaheena, Poornima A. Manjrekar

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Background: Among the many micronutrients, iron has a significant role in the pathogenesis of tuberculosis. The contribution of iron status to the underlying anemia of chronic disease and its effects on the outcome is difficult to assess. Objective of the study: To evaluate the effects of the iron status on pulmonary tuberculosis in response to directly observed treatment short course. Materials & methods: Non-Randomized controlled comparative prospective study was done, ninety newly diagnosed pulmonary tuberculosis cases were selected based on sputum smear positive & chest X-ray reports and were followed up till they completed the intensive phase of DOTS therapy. The patients were divided equally based on their baseline hemoglobin levels as anemic (males: 9 - 12g/dL; females: 8-11g/dL) and non-Anemic (males: >12g/dl; females: >11g/dl). The iron status was assessed by estimating serum iron profile and ferritin at baseline and after completion of intensive phase therapy.C- reactive protein (CRP) was also done. Results: Serum iron, TIBC, transferrin saturation, significantly increased (p < 0.001), followed by significant decrease in S. ferritin and CRP (p < 0.001) in both the groups at the end of intensive phase therapy. 15 cases tested sputum smear positive (10 in the anemic group, 5 in the non-Anemic group) at the end of follow-up period. Conclusion: At the end of intensive phase therapy, improvement of BMI, iron status and CRP was observed in both the groups to a similar extent without any iron supplementation. However, more people in the anemic group remained sputum smear-positive at the end of intensive phase of DOTS therapy indicating that co-existence of anemia was a hindrance to the outcome.

Original languageEnglish
Pages (from-to)15-21
Number of pages7
JournalBiomedicine (India)
Issue number2
Publication statusPublished - 01-04-2016


All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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