Effects of Nardostachys jatamansi on biogenic amines and inhibitory amino acids in the rat brain

V. Prabhu, K. Sudhakar Karanth, A. Rao

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Abstract

The effect of acute and subchronic administration of an alcoholic extract of the roots of Nardostachus jatamansi on norepinephrine (NE), dopamine (DA), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), γ-aminobutyric acid (GABA), and taurine were studied in male albino Wistar rats. The acute oral administration of the extract did not change the level of NE and DA but resulted in a significant increase in the level of 5-HT and 5-HIAA. A significant increase in the level of GABA and taurine was observed in the drug-treated groups when compared to the controls. A 15-day treatment resulted in a significant increase in the levels of NE, DA, 5-HT, 5-HIAA, and GABA. These data indicate that the alcoholic extract of the roots of N. jatamansi causes an overall increase in the levels of central monoamines and inhibitory amino acids.

Original languageEnglish
Pages (from-to)114-117
Number of pages4
JournalPlanta Medica
Volume60
Issue number2
Publication statusPublished - 01-01-1994
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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