Effects of Nardostachys jatamansi on biogenic amines and inhibitory amino acids in the rat brain

V. Prabhu, K. Sudhakar Karanth, A. Rao

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The effect of acute and subchronic administration of an alcoholic extract of the roots of Nardostachus jatamansi on norepinephrine (NE), dopamine (DA), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), γ-aminobutyric acid (GABA), and taurine were studied in male albino Wistar rats. The acute oral administration of the extract did not change the level of NE and DA but resulted in a significant increase in the level of 5-HT and 5-HIAA. A significant increase in the level of GABA and taurine was observed in the drug-treated groups when compared to the controls. A 15-day treatment resulted in a significant increase in the levels of NE, DA, 5-HT, 5-HIAA, and GABA. These data indicate that the alcoholic extract of the roots of N. jatamansi causes an overall increase in the levels of central monoamines and inhibitory amino acids.

Original languageEnglish
Pages (from-to)114-117
Number of pages4
JournalPlanta Medica
Volume60
Issue number2
Publication statusPublished - 01-01-1994
Externally publishedYes

Fingerprint

Nardostachys
Biogenic Amines
Hydroxyindoleacetic Acid
Rats
Brain
Serotonin
gamma-Aminobutyric Acid
Amino Acids
Dopamine
Norepinephrine
Taurine
Aminobutyrates
Oral Administration
Wistar Rats
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Prabhu, V. ; Sudhakar Karanth, K. ; Rao, A. / Effects of Nardostachys jatamansi on biogenic amines and inhibitory amino acids in the rat brain. In: Planta Medica. 1994 ; Vol. 60, No. 2. pp. 114-117.
@article{3bfb5c9c9b844fbba01ecdbe888b11ab,
title = "Effects of Nardostachys jatamansi on biogenic amines and inhibitory amino acids in the rat brain",
abstract = "The effect of acute and subchronic administration of an alcoholic extract of the roots of Nardostachus jatamansi on norepinephrine (NE), dopamine (DA), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), γ-aminobutyric acid (GABA), and taurine were studied in male albino Wistar rats. The acute oral administration of the extract did not change the level of NE and DA but resulted in a significant increase in the level of 5-HT and 5-HIAA. A significant increase in the level of GABA and taurine was observed in the drug-treated groups when compared to the controls. A 15-day treatment resulted in a significant increase in the levels of NE, DA, 5-HT, 5-HIAA, and GABA. These data indicate that the alcoholic extract of the roots of N. jatamansi causes an overall increase in the levels of central monoamines and inhibitory amino acids.",
author = "V. Prabhu and {Sudhakar Karanth}, K. and A. Rao",
year = "1994",
month = "1",
day = "1",
language = "English",
volume = "60",
pages = "114--117",
journal = "Planta Medica",
issn = "0032-0943",
publisher = "Georg Thieme Verlag",
number = "2",

}

Prabhu, V, Sudhakar Karanth, K & Rao, A 1994, 'Effects of Nardostachys jatamansi on biogenic amines and inhibitory amino acids in the rat brain', Planta Medica, vol. 60, no. 2, pp. 114-117.

Effects of Nardostachys jatamansi on biogenic amines and inhibitory amino acids in the rat brain. / Prabhu, V.; Sudhakar Karanth, K.; Rao, A.

In: Planta Medica, Vol. 60, No. 2, 01.01.1994, p. 114-117.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of Nardostachys jatamansi on biogenic amines and inhibitory amino acids in the rat brain

AU - Prabhu, V.

AU - Sudhakar Karanth, K.

AU - Rao, A.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - The effect of acute and subchronic administration of an alcoholic extract of the roots of Nardostachus jatamansi on norepinephrine (NE), dopamine (DA), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), γ-aminobutyric acid (GABA), and taurine were studied in male albino Wistar rats. The acute oral administration of the extract did not change the level of NE and DA but resulted in a significant increase in the level of 5-HT and 5-HIAA. A significant increase in the level of GABA and taurine was observed in the drug-treated groups when compared to the controls. A 15-day treatment resulted in a significant increase in the levels of NE, DA, 5-HT, 5-HIAA, and GABA. These data indicate that the alcoholic extract of the roots of N. jatamansi causes an overall increase in the levels of central monoamines and inhibitory amino acids.

AB - The effect of acute and subchronic administration of an alcoholic extract of the roots of Nardostachus jatamansi on norepinephrine (NE), dopamine (DA), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), γ-aminobutyric acid (GABA), and taurine were studied in male albino Wistar rats. The acute oral administration of the extract did not change the level of NE and DA but resulted in a significant increase in the level of 5-HT and 5-HIAA. A significant increase in the level of GABA and taurine was observed in the drug-treated groups when compared to the controls. A 15-day treatment resulted in a significant increase in the levels of NE, DA, 5-HT, 5-HIAA, and GABA. These data indicate that the alcoholic extract of the roots of N. jatamansi causes an overall increase in the levels of central monoamines and inhibitory amino acids.

UR - http://www.scopus.com/inward/record.url?scp=0028199773&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028199773&partnerID=8YFLogxK

M3 - Article

C2 - 8202559

AN - SCOPUS:0028199773

VL - 60

SP - 114

EP - 117

JO - Planta Medica

JF - Planta Medica

SN - 0032-0943

IS - 2

ER -