Effects of piracetam on retention and biogenic amine turnover in albino rats

K. Nalini, K. S. Karanth, A. Rao, A. R. Aroor

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The chronic effects of orally administered 2-pyrrolidone acetamide (piracetam) on one-trial, passive avoidance task were studied in albino rats. The effects on the contents of norepinephrine (NE), dopamine (DA), and serotonin (5-HT) in the brain and on the levels of their metabolites both in the brain and urine were also assessed. Significant improvement was observed in the retention ability compared with saline-administered controls. The contents of NE, DA, and 5-HT and their metabolites in the brain were significantly decreased after piracetam administration. The urinary metabolite levels were also significantly decreased except total 3-methoxy-4-hydroxyphenyl glycol (MHPG). These data indicate that piracetam causes an overall decrease in the turnover of central monoamines. Thus, the results of this study implicate the involvement of NE, DA, and 5-HT systems in learning and memory processes. Piracetam did not exert any GABAergic effect as shown by the absence of change in the brain GABA levels.

Original languageEnglish
Pages (from-to)859-864
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume42
Issue number4
DOIs
Publication statusPublished - 01-01-1992

Fingerprint

Piracetam
Biogenic Amines
Rats
Brain
Serotonin
Metabolites
Dopamine
Norepinephrine
GABA Agents
Glycols
Aptitude
gamma-Aminobutyric Acid
Learning
Urine
Data storage equipment
Retention (Psychology)

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Nalini, K. ; Karanth, K. S. ; Rao, A. ; Aroor, A. R. / Effects of piracetam on retention and biogenic amine turnover in albino rats. In: Pharmacology, Biochemistry and Behavior. 1992 ; Vol. 42, No. 4. pp. 859-864.
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Effects of piracetam on retention and biogenic amine turnover in albino rats. / Nalini, K.; Karanth, K. S.; Rao, A.; Aroor, A. R.

In: Pharmacology, Biochemistry and Behavior, Vol. 42, No. 4, 01.01.1992, p. 859-864.

Research output: Contribution to journalArticle

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