Effects of sodium iodide on inflammation and its interaction with aspirin and mefenamic acid in albino rats

R.R. Shenoy, T.S. Arun, P.A. Patil

Research output: Contribution to journalArticle

Abstract

Objective: To investigate the effects of sodium iodide on acute and sub-acute inflammation in albino rats and to explore its interaction with aspirin and mefenamic acid Methods: Sodium iodide was evaluated for its anti-inflammatory action by carrageenan induced and foreign body induced inflammation in albino rats. The combinations of sodium iodide + aspirin and sodium iodide + mefenamic acid were also investigated for their effects on inflammation. Results: Sodium iodide potentiated anti- inflammatory activity of aspirin and mefenamic acid in acute inflammation. In sub-acute model, sodium iodide (SAI dose) when combined with aspirin 54 mg/kg b.w. failed to show the significant anti- inflammatory activity. Similarly, sodium iodide failed to potentiate anti- inflammatory of mefenamic acid (SAI dose) and the mean granuloma dry weight was 16.46±2.17mg. Conclusion: Sodium iodide in its therapeutic (400mg/ day) equivalent dose showed significant anti- inflammatory activity in the acute model of inflammation.
Original languageEnglish
Pages (from-to)333-350
Number of pages18
JournalPharmacologyonline
Volume3
Publication statusPublished - 2007

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