Effects of sodium iodide on inflammation and its interaction with aspirin and mefenamic acid in albino rats

R.R. Shenoy, T.S. Arun, P.A. Patil

Research output: Contribution to journalArticle

Abstract

Objective: To investigate the effects of sodium iodide on acute and sub-acute inflammation in albino rats and to explore its interaction with aspirin and mefenamic acid Methods: Sodium iodide was evaluated for its anti-inflammatory action by carrageenan induced and foreign body induced inflammation in albino rats. The combinations of sodium iodide + aspirin and sodium iodide + mefenamic acid were also investigated for their effects on inflammation. Results: Sodium iodide potentiated anti- inflammatory activity of aspirin and mefenamic acid in acute inflammation. In sub-acute model, sodium iodide (SAI dose) when combined with aspirin 54 mg/kg b.w. failed to show the significant anti- inflammatory activity. Similarly, sodium iodide failed to potentiate anti- inflammatory of mefenamic acid (SAI dose) and the mean granuloma dry weight was 16.46±2.17mg. Conclusion: Sodium iodide in its therapeutic (400mg/ day) equivalent dose showed significant anti- inflammatory activity in the acute model of inflammation.
Original languageEnglish
Pages (from-to)333-350
Number of pages18
JournalPharmacologyonline
Volume3
Publication statusPublished - 2007

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Mefenamic Acid
Sodium Iodide
Aspirin
Inflammation
Anti-Inflammatory Agents
Carrageenan
Foreign Bodies
Granuloma
Weights and Measures

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title = "Effects of sodium iodide on inflammation and its interaction with aspirin and mefenamic acid in albino rats",
abstract = "Objective: To investigate the effects of sodium iodide on acute and sub-acute inflammation in albino rats and to explore its interaction with aspirin and mefenamic acid Methods: Sodium iodide was evaluated for its anti-inflammatory action by carrageenan induced and foreign body induced inflammation in albino rats. The combinations of sodium iodide + aspirin and sodium iodide + mefenamic acid were also investigated for their effects on inflammation. Results: Sodium iodide potentiated anti- inflammatory activity of aspirin and mefenamic acid in acute inflammation. In sub-acute model, sodium iodide (SAI dose) when combined with aspirin 54 mg/kg b.w. failed to show the significant anti- inflammatory activity. Similarly, sodium iodide failed to potentiate anti- inflammatory of mefenamic acid (SAI dose) and the mean granuloma dry weight was 16.46±2.17mg. Conclusion: Sodium iodide in its therapeutic (400mg/ day) equivalent dose showed significant anti- inflammatory activity in the acute model of inflammation.",
author = "R.R. Shenoy and T.S. Arun and P.A. Patil",
note = "Export Date: 10 November 2017 Correspondence Address: Shenoy, R.S.; Manipal College of Pharmaceutical Sciences, Manipal - 576 104 Karnataka, India; email: rekha1003@yahoo.co.in Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; mefenamic acid, 61-68-7; sodium iodide, 7681-82-5 Tradenames: aspirin, Ashok Pharmaceuticals Manufacturers: Ashok Pharmaceuticals; Bluecross Company; Loba References: Robbins, S.L., Cotran, R.S., (1974) Pathological basis of disease, p. 55. , 2nd ed. London: Saunders company;; Fowler, R.J., Moncada, S., (1985) Pharmacological basis of therapeutics, pp. 675-715. , 7th ed. Edited by Goodman and Gilman;; Chintakasi, V., (1991) Calcium channel blockers potentiate the antiinflammatory activity of aspirin in albino rats, pp. 56-73. , Dissertation submitted to Karnatak University Dharwad;; Padgilwar, S., (1999) Influence of adrenergic agonists and antagonists on inflammation and their interaction with aspirin, pp. 48-63. , Dissertation submitted to Rajiv Gandhi University, Bangalore;; Solmann. A manual of Pharmacology. 8th ed; 1964: 1121-1124; Orville, J., Stone, M.D., How iodides cure sporotrichosis by increased inflammation (1969) Texas Medicine, 65, pp. 53-54; Egan, R.W., Gale, P.H., Radical scavenging as the mechanism for stimulation of prostaglandin cyclo-oxygenase and depression of inflammation by lipoic acid and sodium iodide (1978) Prostaglandins, 16 (6), pp. 861-869; D' Arcy, P.F., Howard, E.M., Implantation of a pellet (1960) J Pharm Pharmacol, 12, p. 659; David, J.C., Iswariah, Guruswami, M.N., (1966) Pharmacology and phamacotherapeutics, pp. 492-495. , 5th ed;; Sinniah, R., Lye, W.C., (2001) Acute renal failure from hemoglobinuric and interstitial nephritis secondary to iodine and mefenamic acid, 55 (3), pp. 254-258",
year = "2007",
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pages = "333--350",
journal = "Pharmacologyonline",
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Effects of sodium iodide on inflammation and its interaction with aspirin and mefenamic acid in albino rats. / Shenoy, R.R.; Arun, T.S.; Patil, P.A.

In: Pharmacologyonline, Vol. 3, 2007, p. 333-350.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of sodium iodide on inflammation and its interaction with aspirin and mefenamic acid in albino rats

AU - Shenoy, R.R.

AU - Arun, T.S.

AU - Patil, P.A.

N1 - Export Date: 10 November 2017 Correspondence Address: Shenoy, R.S.; Manipal College of Pharmaceutical Sciences, Manipal - 576 104 Karnataka, India; email: rekha1003@yahoo.co.in Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; mefenamic acid, 61-68-7; sodium iodide, 7681-82-5 Tradenames: aspirin, Ashok Pharmaceuticals Manufacturers: Ashok Pharmaceuticals; Bluecross Company; Loba References: Robbins, S.L., Cotran, R.S., (1974) Pathological basis of disease, p. 55. , 2nd ed. London: Saunders company;; Fowler, R.J., Moncada, S., (1985) Pharmacological basis of therapeutics, pp. 675-715. , 7th ed. Edited by Goodman and Gilman;; Chintakasi, V., (1991) Calcium channel blockers potentiate the antiinflammatory activity of aspirin in albino rats, pp. 56-73. , Dissertation submitted to Karnatak University Dharwad;; Padgilwar, S., (1999) Influence of adrenergic agonists and antagonists on inflammation and their interaction with aspirin, pp. 48-63. , Dissertation submitted to Rajiv Gandhi University, Bangalore;; Solmann. A manual of Pharmacology. 8th ed; 1964: 1121-1124; Orville, J., Stone, M.D., How iodides cure sporotrichosis by increased inflammation (1969) Texas Medicine, 65, pp. 53-54; Egan, R.W., Gale, P.H., Radical scavenging as the mechanism for stimulation of prostaglandin cyclo-oxygenase and depression of inflammation by lipoic acid and sodium iodide (1978) Prostaglandins, 16 (6), pp. 861-869; D' Arcy, P.F., Howard, E.M., Implantation of a pellet (1960) J Pharm Pharmacol, 12, p. 659; David, J.C., Iswariah, Guruswami, M.N., (1966) Pharmacology and phamacotherapeutics, pp. 492-495. , 5th ed;; Sinniah, R., Lye, W.C., (2001) Acute renal failure from hemoglobinuric and interstitial nephritis secondary to iodine and mefenamic acid, 55 (3), pp. 254-258

PY - 2007

Y1 - 2007

N2 - Objective: To investigate the effects of sodium iodide on acute and sub-acute inflammation in albino rats and to explore its interaction with aspirin and mefenamic acid Methods: Sodium iodide was evaluated for its anti-inflammatory action by carrageenan induced and foreign body induced inflammation in albino rats. The combinations of sodium iodide + aspirin and sodium iodide + mefenamic acid were also investigated for their effects on inflammation. Results: Sodium iodide potentiated anti- inflammatory activity of aspirin and mefenamic acid in acute inflammation. In sub-acute model, sodium iodide (SAI dose) when combined with aspirin 54 mg/kg b.w. failed to show the significant anti- inflammatory activity. Similarly, sodium iodide failed to potentiate anti- inflammatory of mefenamic acid (SAI dose) and the mean granuloma dry weight was 16.46±2.17mg. Conclusion: Sodium iodide in its therapeutic (400mg/ day) equivalent dose showed significant anti- inflammatory activity in the acute model of inflammation.

AB - Objective: To investigate the effects of sodium iodide on acute and sub-acute inflammation in albino rats and to explore its interaction with aspirin and mefenamic acid Methods: Sodium iodide was evaluated for its anti-inflammatory action by carrageenan induced and foreign body induced inflammation in albino rats. The combinations of sodium iodide + aspirin and sodium iodide + mefenamic acid were also investigated for their effects on inflammation. Results: Sodium iodide potentiated anti- inflammatory activity of aspirin and mefenamic acid in acute inflammation. In sub-acute model, sodium iodide (SAI dose) when combined with aspirin 54 mg/kg b.w. failed to show the significant anti- inflammatory activity. Similarly, sodium iodide failed to potentiate anti- inflammatory of mefenamic acid (SAI dose) and the mean granuloma dry weight was 16.46±2.17mg. Conclusion: Sodium iodide in its therapeutic (400mg/ day) equivalent dose showed significant anti- inflammatory activity in the acute model of inflammation.

M3 - Article

VL - 3

SP - 333

EP - 350

JO - Pharmacologyonline

JF - Pharmacologyonline

SN - 1827-8620

ER -