Abstract
The present study was undertaken to find out the effects of tobacco smoking on innate immune mechanism of the body. A total of 60 adult consenting men in the age group of 30 to 50 years were recruited of which 30 were chronic smokers and the rest were non smoking controls. 5ml of venous blood was drawn from each of the subjects and the following parameters were assessed: phagocytic index of neutrophils (which is an index of neutrophil function and is defined as number of neutrophils positive for ingested microbes per 100 neutrophils), total leucocyte count (TLC), differential count of neutrophils. The values from smokers were compared with those from non-smokers. There was a statistically significant decrease in the phagocytic index among smokers when compared to non-smokers (9.44±6.62 vs 28.16±7.31; p<0.0011). An increase in TLC and neutrophil percentage was found in smokers which were not statistically significant (p=0.37 and p=0.12 respectively). Hence it can be concluded that tobacco smoking adversely affects the capacity of neutrophils to ingest microbes and so has suppressive effect on the innate immune mechanism.
| Original language | English |
|---|---|
| Pages (from-to) | 182-186 |
| Number of pages | 5 |
| Journal | Indian Journal of Physiology and Pharmacology |
| Volume | 62 |
| Issue number | 2 |
| Publication status | Published - 01-04-2018 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Physiology
- Pharmacology
- Physiology (medical)
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Effects of tobacco smoking on innate immunity : A study based on neutrophil phagocytic index. / Thakur, Tanu; Bhide, Arpana; Chaudhury, Abhijit; Thota, Asha; Kasala, Latheef; Hulikal, Narendra.
In: Indian Journal of Physiology and Pharmacology, Vol. 62, No. 2, 01.04.2018, p. 182-186.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effects of tobacco smoking on innate immunity
T2 - A study based on neutrophil phagocytic index
AU - Thakur, Tanu
AU - Bhide, Arpana
AU - Chaudhury, Abhijit
AU - Thota, Asha
AU - Kasala, Latheef
AU - Hulikal, Narendra
PY - 2018/4/1
Y1 - 2018/4/1
N2 - The present study was undertaken to find out the effects of tobacco smoking on innate immune mechanism of the body. A total of 60 adult consenting men in the age group of 30 to 50 years were recruited of which 30 were chronic smokers and the rest were non smoking controls. 5ml of venous blood was drawn from each of the subjects and the following parameters were assessed: phagocytic index of neutrophils (which is an index of neutrophil function and is defined as number of neutrophils positive for ingested microbes per 100 neutrophils), total leucocyte count (TLC), differential count of neutrophils. The values from smokers were compared with those from non-smokers. There was a statistically significant decrease in the phagocytic index among smokers when compared to non-smokers (9.44±6.62 vs 28.16±7.31; p<0.0011). An increase in TLC and neutrophil percentage was found in smokers which were not statistically significant (p=0.37 and p=0.12 respectively). Hence it can be concluded that tobacco smoking adversely affects the capacity of neutrophils to ingest microbes and so has suppressive effect on the innate immune mechanism.
AB - The present study was undertaken to find out the effects of tobacco smoking on innate immune mechanism of the body. A total of 60 adult consenting men in the age group of 30 to 50 years were recruited of which 30 were chronic smokers and the rest were non smoking controls. 5ml of venous blood was drawn from each of the subjects and the following parameters were assessed: phagocytic index of neutrophils (which is an index of neutrophil function and is defined as number of neutrophils positive for ingested microbes per 100 neutrophils), total leucocyte count (TLC), differential count of neutrophils. The values from smokers were compared with those from non-smokers. There was a statistically significant decrease in the phagocytic index among smokers when compared to non-smokers (9.44±6.62 vs 28.16±7.31; p<0.0011). An increase in TLC and neutrophil percentage was found in smokers which were not statistically significant (p=0.37 and p=0.12 respectively). Hence it can be concluded that tobacco smoking adversely affects the capacity of neutrophils to ingest microbes and so has suppressive effect on the innate immune mechanism.
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UR - http://www.scopus.com/inward/citedby.url?scp=85045425494&partnerID=8YFLogxK
M3 - Article
VL - 62
SP - 182
EP - 186
JO - Indian Journal of Physiology and Pharmacology
JF - Indian Journal of Physiology and Pharmacology
SN - 0019-5499
IS - 2
ER -