Efficacy and safety of fixed dose combination of arterolane maleate and piperaquine phosphate in comparison with chloroquine phosphate in children with acute uncomplicated Plasmodium vivax malaria: A phase III, randomised, multicentric study

Neena Valecha, Vimal Goyal, Deo Mishra, Rashmi Das, Neeraj Jauhri, Alok Bhardwaj, Omesh Khurana, Reena Choudhury, Madhukar Pandey, Bantwal Baliga, Susanta Ghosh, Bina Srivastava, Santhosh Soans, Raj Bahl, Ajay Punj, Arjun Roy, Sanjay Sharma, Amit Nasa, Rajinder Jalali, Anupkumar Anvikar

Research output: Contribution to journalArticlepeer-review

Abstract

Background & objectives: In India, the burden of Plasmodium vivax malaria has been projected to be highest in some areas. This study investigated the efficacy and safety of fixed dose combination (FDC) of arterolane maleate (AM) 37.5 mg and piperaquine phosphate 187.5 mg (PQP) dispersible tablets and (not with) chloroquine in the treatment of uncomplicated vivax malaria in pediatric patients. Methods: This multicentric, open-label trial was carried out at 12 sites in India. A total of 164 patients aged 6 months to 12 years with P. vivax malaria were randomized in a ratio of 2:1 to AM-PQP (111 patients) or chloroquine (53 patients) arms. The duration of follow up was 42 days. Results: At 72 hours, the proportion of a parasitaemic and afebrile patients was 100% in both treatment arms in per protocol (PP) population, and 98.2% and 100% [95% CI: -1.8 (-6.33 to 5.08)] in AM-PQP and chloroquine arms, respectively, in intent to treat (ITT) population. The efficacy and safety of AM-PQP was found to be comparable to chloroquine in the treatment of uncomplicated P. vivax malaria in pediatric patients. Overall, the cure rate at Day 28 and 42 was >95% for both AM-PQP or CQ. The commonly reported clinical adverse event was vomiting. No patient was discontinued for any QTc abnormality. Interpretation & conclusion: The efficacy and safety of FDC of arterolane maleate and piperaquine phosphate was found to be comparable to chloroquine for treatment of uncomplicated P. vivax malaria in pediatric patients.

Original languageEnglish
Pages (from-to)213-220
Number of pages8
JournalJournal of Vector Borne Diseases
Volume57
Issue number3
DOIs
Publication statusPublished - 09-2020

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases

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