Efficacy and safety of tenecteplase in pulmonary embolism

Anand N. Shukla, Bhavesh Thakkar, Ashwal A. Jayaram, Tarun H. Madan, Gaurav D. Gandhi

Research output: Contribution to journalArticle

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Abstract

Pulmonary embolism (PE) is a relatively common life-threatening cardiovascular condition associated with significant morbidity and mortality. We present the efficacy and safety data of weight-adjusted tenecteplase in 30 consecutive patients of acute PE. 30 patients (22 male, 8 female) with acute PE were included in the study and divided into three groups: (1) Acute PE complicated by shock stage and/or persistent hypotension (12 patients). (2) RV dilatation and/or dysfunction without hypotension (14 patients). (3) Severe hypoxemia without hypotension and RV dysfunction (4 patients). Predominant symptoms were dyspnoea, cough, chest pain, syncope and haemoptysis, noted in 100 % (30), 40 % (12), 54 % (16), 32 % (9) and 10 % (3) of patients respectively. RV dilatation and dyskinesia were present in 86 %, septal paradoxical movement in 73 % and inferior venacava collapse absent in 53 % of patients respectively. 12 patients presented with acute PE and cardiogenic shock, 14 patients showed RV dilatation and dysfunction with systolic BP >90 mmHg and four patients were having RV dilation without dysfunction but severe hypoxemia. There was significant reduction in right ventricular systolic pressure and improvement in right ventricular dysfunction. Our study shows that tenecteplase is very effective and safe in the treatment of PE with minimal risk of bleeding in high risk group and intermediate risk and even in selective low risk category group of patients. However, in view of small number of patients in study group, a large multicentre randomized study would be required to draw a firm conclusion regarding the thrombolysis in low risk category patient.

Original languageEnglish
Pages (from-to)24-29
Number of pages6
JournalJournal of Thrombosis and Thrombolysis
Volume38
Issue number1
DOIs
Publication statusPublished - 01-01-2014

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Pulmonary Embolism
Safety
Dilatation
Hypotension
tenecteplase
Right Ventricular Dysfunction
Cardiogenic Shock
Hemoptysis
Dyskinesias
Syncope
Ventricular Pressure
Chest Pain
Cough
Dyspnea
Multicenter Studies
Shock
Hemorrhage
Blood Pressure
Morbidity
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Hematology
  • Cardiology and Cardiovascular Medicine

Cite this

Shukla, Anand N. ; Thakkar, Bhavesh ; Jayaram, Ashwal A. ; Madan, Tarun H. ; Gandhi, Gaurav D. / Efficacy and safety of tenecteplase in pulmonary embolism. In: Journal of Thrombosis and Thrombolysis. 2014 ; Vol. 38, No. 1. pp. 24-29.
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Efficacy and safety of tenecteplase in pulmonary embolism. / Shukla, Anand N.; Thakkar, Bhavesh; Jayaram, Ashwal A.; Madan, Tarun H.; Gandhi, Gaurav D.

In: Journal of Thrombosis and Thrombolysis, Vol. 38, No. 1, 01.01.2014, p. 24-29.

Research output: Contribution to journalArticle

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