Efficacy of anti-staphylococcal protein P128 for the treatment of canine pyoderma

Potential applications

Raghu Patil Junjappa, Srividya Narayanamurthy Desai, Panchali Roy, Nagalakshmi Narasimhaswamy, Juliet Roshini Mohan Raj, Murali Durgaiah, Aradhana Vipra, Udaya Ravi Bhat, Smitha Komarla Satyanarayana, Nandini Shankara, Suneelkumar Muragesh Basingi, Jagadeesh Janardhan Bhat, Sukumar Hariharan, Bharathi Sriram, Sriram Padmanabhan

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In this study, we demonstrate the antibacterial activity of P128 on Staphylococcus isolates responsible for canine pyoderma. Eighty seven swabs were collected from dogs suffering from pyoderma and subjected to antibiotic sensitivity test and 46 Staphylococcus strains were isolated and characterized. In-vitro antimicrobial susceptibility testing with P128 was done by Minimum Inhibitory Concentration (MIC) method as per CLSI guidelines. All the Staphylococci isolated from the dogs with pyoderma, although showed resistance to various antibiotics tested, were lysed by P128. Clinical efficacy of P128 was examined in 17 dogs with pyoderma by application of the P128 hydrogel twice daily for 8 days and the results indicated complete healing of all the lesions of all the dogs under treatment. Under the conditions of this study, P128 was found to be a potent convenient proteinaceous drug for the treatment of staphylococcal pyoderma in dogs.

Original languageEnglish
Pages (from-to)217-228
Number of pages12
JournalVeterinary Research Communications
Volume37
Issue number3
DOIs
Publication statusPublished - 01-09-2013

Fingerprint

Pyoderma
pyoderma
Canidae
Dogs
Staphylococcus
dogs
Proteins
proteins
Anti-Bacterial Agents
antibiotics
Hydrogel
Microbial Sensitivity Tests
hydrocolloids
minimum inhibitory concentration
lesions (animal)
drug therapy
Guidelines
anti-infective agents
testing
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

Junjappa, Raghu Patil ; Desai, Srividya Narayanamurthy ; Roy, Panchali ; Narasimhaswamy, Nagalakshmi ; Raj, Juliet Roshini Mohan ; Durgaiah, Murali ; Vipra, Aradhana ; Bhat, Udaya Ravi ; Satyanarayana, Smitha Komarla ; Shankara, Nandini ; Basingi, Suneelkumar Muragesh ; Bhat, Jagadeesh Janardhan ; Hariharan, Sukumar ; Sriram, Bharathi ; Padmanabhan, Sriram. / Efficacy of anti-staphylococcal protein P128 for the treatment of canine pyoderma : Potential applications. In: Veterinary Research Communications. 2013 ; Vol. 37, No. 3. pp. 217-228.
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abstract = "In this study, we demonstrate the antibacterial activity of P128 on Staphylococcus isolates responsible for canine pyoderma. Eighty seven swabs were collected from dogs suffering from pyoderma and subjected to antibiotic sensitivity test and 46 Staphylococcus strains were isolated and characterized. In-vitro antimicrobial susceptibility testing with P128 was done by Minimum Inhibitory Concentration (MIC) method as per CLSI guidelines. All the Staphylococci isolated from the dogs with pyoderma, although showed resistance to various antibiotics tested, were lysed by P128. Clinical efficacy of P128 was examined in 17 dogs with pyoderma by application of the P128 hydrogel twice daily for 8 days and the results indicated complete healing of all the lesions of all the dogs under treatment. Under the conditions of this study, P128 was found to be a potent convenient proteinaceous drug for the treatment of staphylococcal pyoderma in dogs.",
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Junjappa, RP, Desai, SN, Roy, P, Narasimhaswamy, N, Raj, JRM, Durgaiah, M, Vipra, A, Bhat, UR, Satyanarayana, SK, Shankara, N, Basingi, SM, Bhat, JJ, Hariharan, S, Sriram, B & Padmanabhan, S 2013, 'Efficacy of anti-staphylococcal protein P128 for the treatment of canine pyoderma: Potential applications', Veterinary Research Communications, vol. 37, no. 3, pp. 217-228. https://doi.org/10.1007/s11259-013-9565-y

Efficacy of anti-staphylococcal protein P128 for the treatment of canine pyoderma : Potential applications. / Junjappa, Raghu Patil; Desai, Srividya Narayanamurthy; Roy, Panchali; Narasimhaswamy, Nagalakshmi; Raj, Juliet Roshini Mohan; Durgaiah, Murali; Vipra, Aradhana; Bhat, Udaya Ravi; Satyanarayana, Smitha Komarla; Shankara, Nandini; Basingi, Suneelkumar Muragesh; Bhat, Jagadeesh Janardhan; Hariharan, Sukumar; Sriram, Bharathi; Padmanabhan, Sriram.

In: Veterinary Research Communications, Vol. 37, No. 3, 01.09.2013, p. 217-228.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Efficacy of anti-staphylococcal protein P128 for the treatment of canine pyoderma

T2 - Potential applications

AU - Junjappa, Raghu Patil

AU - Desai, Srividya Narayanamurthy

AU - Roy, Panchali

AU - Narasimhaswamy, Nagalakshmi

AU - Raj, Juliet Roshini Mohan

AU - Durgaiah, Murali

AU - Vipra, Aradhana

AU - Bhat, Udaya Ravi

AU - Satyanarayana, Smitha Komarla

AU - Shankara, Nandini

AU - Basingi, Suneelkumar Muragesh

AU - Bhat, Jagadeesh Janardhan

AU - Hariharan, Sukumar

AU - Sriram, Bharathi

AU - Padmanabhan, Sriram

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JO - Veterinary Research Communications

JF - Veterinary Research Communications

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