EFFICACY OF DEXAMETHASONE PULSE THERAPY IN PROGRESSIVE SYSTEMIC SCLEROSIS

BALLAMBAT SATHISH PAI, CHAKRAVARTHI R. SRINIVAS, LAKSHMINARAYANAN SABITHA, SHRUTAKIRTHI D. SHENOI, CHANDRASEKHARAN N. BALACHANDRAN, SANDHYA ACHARYA

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Abstract

Background. Systemic sclerosis is a disease of unknown etiology for which no specific treatment is effective. Pulse therapy with corticosteroids has been tried for various autoimmune disorders with minimal side effects. We undertook this study to determine the efficacy of dexamethasone pulse therapy in progressive systemic sclerosis (PSS). Methods. Five women with PSS between the ages 30 and 60 years, received 100 mg dexamethasone in 500 mL of 5% dextrose by slow intravenous infusion over 3 hours for 3 consecutive days, once a month. Results. All patients had symptomatic and clinical improvement. The vital capacity improved in three and posttreatment histopathologic regression was seen in two patients. Conclusions. Dexamethasone pulse therapy may provide an additional option for treating systemic sclerosis.

Original languageEnglish
Pages (from-to)726-728
Number of pages3
JournalInternational Journal of Dermatology
Volume34
Issue number10
DOIs
Publication statusPublished - 01-01-1995

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Diffuse Scleroderma
Dexamethasone
Systemic Scleroderma
Vital Capacity
Therapeutics
Intravenous Infusions
Adrenal Cortex Hormones
Glucose

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

PAI, BALLAMBAT. SATHISH., SRINIVAS, CHAKRAVARTHI. R., SABITHA, LAKSHMINARAYANAN., SHENOI, SHRUTAKIRTHI. D., BALACHANDRAN, CHANDRASEKHARAN. N., & ACHARYA, SANDHYA. (1995). EFFICACY OF DEXAMETHASONE PULSE THERAPY IN PROGRESSIVE SYSTEMIC SCLEROSIS. International Journal of Dermatology, 34(10), 726-728. https://doi.org/10.1111/j.1365-4362.1995.tb04664.x
PAI, BALLAMBAT SATHISH ; SRINIVAS, CHAKRAVARTHI R. ; SABITHA, LAKSHMINARAYANAN ; SHENOI, SHRUTAKIRTHI D. ; BALACHANDRAN, CHANDRASEKHARAN N. ; ACHARYA, SANDHYA. / EFFICACY OF DEXAMETHASONE PULSE THERAPY IN PROGRESSIVE SYSTEMIC SCLEROSIS. In: International Journal of Dermatology. 1995 ; Vol. 34, No. 10. pp. 726-728.
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PAI, BALLAMBATSATHISH, SRINIVAS, CHAKRAVARTHIR, SABITHA, LAKSHMINARAYANAN, SHENOI, SHRUTAKIRTHID, BALACHANDRAN, CHANDRASEKHARANN & ACHARYA, SANDHYA 1995, 'EFFICACY OF DEXAMETHASONE PULSE THERAPY IN PROGRESSIVE SYSTEMIC SCLEROSIS', International Journal of Dermatology, vol. 34, no. 10, pp. 726-728. https://doi.org/10.1111/j.1365-4362.1995.tb04664.x

EFFICACY OF DEXAMETHASONE PULSE THERAPY IN PROGRESSIVE SYSTEMIC SCLEROSIS. / PAI, BALLAMBAT SATHISH; SRINIVAS, CHAKRAVARTHI R.; SABITHA, LAKSHMINARAYANAN; SHENOI, SHRUTAKIRTHI D.; BALACHANDRAN, CHANDRASEKHARAN N.; ACHARYA, SANDHYA.

In: International Journal of Dermatology, Vol. 34, No. 10, 01.01.1995, p. 726-728.

Research output: Contribution to journalArticle

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AU - PAI, BALLAMBAT SATHISH

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AB - Background. Systemic sclerosis is a disease of unknown etiology for which no specific treatment is effective. Pulse therapy with corticosteroids has been tried for various autoimmune disorders with minimal side effects. We undertook this study to determine the efficacy of dexamethasone pulse therapy in progressive systemic sclerosis (PSS). Methods. Five women with PSS between the ages 30 and 60 years, received 100 mg dexamethasone in 500 mL of 5% dextrose by slow intravenous infusion over 3 hours for 3 consecutive days, once a month. Results. All patients had symptomatic and clinical improvement. The vital capacity improved in three and posttreatment histopathologic regression was seen in two patients. Conclusions. Dexamethasone pulse therapy may provide an additional option for treating systemic sclerosis.

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