Electric field mapping and structure-activity relationships for some neurotransmitters: serotonin congeners

C. Santhosh, P. C. Mishra

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Electric field maps of neutral and cationic forms of 5-hydroxytryptamine (serotonin), 5-chlorotryptamine, 6-hydroxytryptamine and 4-hydroxytryptamine have been studied. The binding of these species through the substituent at position 5 and the amino group, with the receptor, are shown to be of crucial significance. A relationship between the observed potencies of the different compounds and electric fields near the substituent at position 5, has been shown to exist.

Original languageEnglish
Pages (from-to)77-81
Number of pages5
JournalJournal of Molecular Structure: THEOCHEM
Issue number1
Publication statusPublished - 20-03-1994


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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