The results obtained by us on the ultraviolet absorption and fluorescence spectra of adenine and guanine and partially those of 8-azaguanine and 8-bromoguanine have been discussed and interpreted with the help of molecular orbital calculations. Effects of oxygenation and nitrogenation on the spectra and possible tautomerisations of molecules induced by oxygen and UV irradiation have mainly been the subjects of interest. Oscillations observed in the absorption spectra of guanine in aqueous solutions under UV irradiation have been interpreted in terms of the tautomerisation of the molecule following its slow complexation with the dissolved oxygen. This complexation of oxygen with guanine in DNA may cause lethal damage to biological systems including carcinogenesis.
|Number of pages||12|
|Journal||Proceedings of the Indian Academy of Sciences - Chemical Sciences|
|Publication status||Published - 01-12-1992|
All Science Journal Classification (ASJC) codes