Electrospun gelatin nanofibers as drug carrier: Effect of crosslinking on sustained release

Anindita Laha, Chandra S. Sharma, Saptarshi Majumdar

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

This study aims to develop a natural biopolymer based nanofabric as an oral drug carrier to deliver a model hydrophobic drug (piperine) in a sustained and controlled manner over prolonged time. For that, we electrospun gelatin nanofabric mesh followed by crosslinking using saturated vapor of glutaraldehyde (GTA) for 8 mins to improve the water resistive properties. Later, we investigated the effect of different crosslinking strategies and found that layer-by-layer crosslinking not only provides an improved structural integrity, thermal and chemical stability of drug but also yields a tight control over sustained drug release up to 8 h.

Original languageEnglish
Pages (from-to)3484-3491
Number of pages8
JournalMaterials Today: Proceedings
Volume3
Issue number10
DOIs
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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