TY - JOUR
T1 - Elevated levels of GDF-15 is associated with increased angiotensin II in hypertensive patients with Type 2 diabetes
AU - Adela, Ramu
AU - Mohammed, Soheb Anwar
AU - Kanwal, Abhinav
AU - Vishwakarma, Gayatri
AU - Reddy, Podduturi Naveen Chander
AU - Banerjee, Sanjay K.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Aim: Circulatory GDF-15, angiotensin II (Ang-II) and GDF-15 mRNA expression levels were examined in three groups, in other words, control (n = 25), Type 2 diabetes (T2DM; n = 25) and Type 2 diabetes with hypertension (T2DM-HTN; n = 36). Results: T2DM and T2DM-HTN subjects had significantly (p < 0.05) higher GDF-15 and Ang-II levels compared with control subjects. Significant positive correlation was found between Ang-II and GDF-15 levels. GDF-15 mRNA expression from blood cells was significantly elevated in T2DM-HTN (p < 0.05) but not in T2DM subjects. GDF-15 mRNA expression was significantly elevated in Ang-II-treated (50 nM) THP-1 (p < 0.001) and H9C2 (p < 0.05) cells but not altered after high glucose treatment. Conclusion: Collectively, our data suggest that higher levels of GDF-15 is associated with increased Ang-II levels in diabetic patients with concurrent hypertension.
AB - Aim: Circulatory GDF-15, angiotensin II (Ang-II) and GDF-15 mRNA expression levels were examined in three groups, in other words, control (n = 25), Type 2 diabetes (T2DM; n = 25) and Type 2 diabetes with hypertension (T2DM-HTN; n = 36). Results: T2DM and T2DM-HTN subjects had significantly (p < 0.05) higher GDF-15 and Ang-II levels compared with control subjects. Significant positive correlation was found between Ang-II and GDF-15 levels. GDF-15 mRNA expression from blood cells was significantly elevated in T2DM-HTN (p < 0.05) but not in T2DM subjects. GDF-15 mRNA expression was significantly elevated in Ang-II-treated (50 nM) THP-1 (p < 0.001) and H9C2 (p < 0.05) cells but not altered after high glucose treatment. Conclusion: Collectively, our data suggest that higher levels of GDF-15 is associated with increased Ang-II levels in diabetic patients with concurrent hypertension.
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U2 - 10.2217/pme-2016-0030
DO - 10.2217/pme-2016-0030
M3 - Article
AN - SCOPUS:84978878140
SN - 1741-0541
VL - 13
SP - 325
EP - 336
JO - Personalized Medicine
JF - Personalized Medicine
IS - 4
ER -
