Elevated levels of GDF-15 is associated with increased angiotensin II in hypertensive patients with Type 2 diabetes

Ramu Adela, Soheb Anwar Mohammed, Abhinav Kanwal, Gayatri Vishwakarma, Podduturi Naveen Chander Reddy, Sanjay K. Banerjee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aim: Circulatory GDF-15, angiotensin II (Ang-II) and GDF-15 mRNA expression levels were examined in three groups, in other words, control (n = 25), Type 2 diabetes (T2DM; n = 25) and Type 2 diabetes with hypertension (T2DM-HTN; n = 36). Results: T2DM and T2DM-HTN subjects had significantly (p < 0.05) higher GDF-15 and Ang-II levels compared with control subjects. Significant positive correlation was found between Ang-II and GDF-15 levels. GDF-15 mRNA expression from blood cells was significantly elevated in T2DM-HTN (p < 0.05) but not in T2DM subjects. GDF-15 mRNA expression was significantly elevated in Ang-II-treated (50 nM) THP-1 (p < 0.001) and H9C2 (p < 0.05) cells but not altered after high glucose treatment. Conclusion: Collectively, our data suggest that higher levels of GDF-15 is associated with increased Ang-II levels in diabetic patients with concurrent hypertension.

Original languageEnglish
Pages (from-to)325-336
Number of pages12
JournalPersonalized Medicine
Volume13
Issue number4
DOIs
Publication statusPublished - 01-07-2016

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Growth Differentiation Factor 15
Angiotensin II
Type 2 Diabetes Mellitus
Messenger RNA
Hypertension
Blood Cells
Glucose

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Adela, Ramu ; Mohammed, Soheb Anwar ; Kanwal, Abhinav ; Vishwakarma, Gayatri ; Reddy, Podduturi Naveen Chander ; Banerjee, Sanjay K. / Elevated levels of GDF-15 is associated with increased angiotensin II in hypertensive patients with Type 2 diabetes. In: Personalized Medicine. 2016 ; Vol. 13, No. 4. pp. 325-336.
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Elevated levels of GDF-15 is associated with increased angiotensin II in hypertensive patients with Type 2 diabetes. / Adela, Ramu; Mohammed, Soheb Anwar; Kanwal, Abhinav; Vishwakarma, Gayatri; Reddy, Podduturi Naveen Chander; Banerjee, Sanjay K.

In: Personalized Medicine, Vol. 13, No. 4, 01.07.2016, p. 325-336.

Research output: Contribution to journalArticle

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AU - Mohammed, Soheb Anwar

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AU - Reddy, Podduturi Naveen Chander

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