Elevated levels of GDF-15 is associated with increased angiotensin II in hypertensive patients with Type 2 diabetes

Ramu Adela, Soheb Anwar Mohammed, Abhinav Kanwal, Gayatri Vishwakarma, Podduturi Naveen Chander Reddy, Sanjay K. Banerjee

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Abstract

Aim: Circulatory GDF-15, angiotensin II (Ang-II) and GDF-15 mRNA expression levels were examined in three groups, in other words, control (n = 25), Type 2 diabetes (T2DM; n = 25) and Type 2 diabetes with hypertension (T2DM-HTN; n = 36). Results: T2DM and T2DM-HTN subjects had significantly (p < 0.05) higher GDF-15 and Ang-II levels compared with control subjects. Significant positive correlation was found between Ang-II and GDF-15 levels. GDF-15 mRNA expression from blood cells was significantly elevated in T2DM-HTN (p < 0.05) but not in T2DM subjects. GDF-15 mRNA expression was significantly elevated in Ang-II-treated (50 nM) THP-1 (p < 0.001) and H9C2 (p < 0.05) cells but not altered after high glucose treatment. Conclusion: Collectively, our data suggest that higher levels of GDF-15 is associated with increased Ang-II levels in diabetic patients with concurrent hypertension.

Original languageEnglish
Pages (from-to)325-336
Number of pages12
JournalPersonalized Medicine
Volume13
Issue number4
DOIs
Publication statusPublished - 01-07-2016

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All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Adela, R., Mohammed, S. A., Kanwal, A., Vishwakarma, G., Reddy, P. N. C., & Banerjee, S. K. (2016). Elevated levels of GDF-15 is associated with increased angiotensin II in hypertensive patients with Type 2 diabetes. Personalized Medicine, 13(4), 325-336. https://doi.org/10.2217/pme-2016-0030