TY - JOUR
T1 - Elucidating the microscopic and computational techniques to study the structure and pathology of SARS-CoVs
AU - Kaniyala Melanthota, Sindhoora
AU - Banik, Soumyabrata
AU - Chakraborty, Ishita
AU - Pallen, Sparsha
AU - Gopal, Dharshini
AU - Chakrabarti, Shweta
AU - Mazumder, Nirmal
N1 - Funding Information:
We thank SERB‐Department of Science and Technology (DST), Government of India for the financial support (Project Number—ECR/2016/001944). We thank Dr. K Satyamoorthy, Director, Manipal School of Life Sciences (MSLS), Manipal Academy of Higher Education (MAHE), Manipal, India and Dr. KK Mahato, HoD, Department of Biophysics, MSLS, MAHE, Manipal, India for their constant support and guidance. We would also express our sincere gratitude to MAHE, Manipal for providing the infrastructure needed for the study.
Funding Information:
We thank SERB-Department of Science and Technology (DST), Government of India for the financial support (Project Number?ECR/2016/001944). We thank Dr. K Satyamoorthy, Director, Manipal School of Life Sciences (MSLS), Manipal Academy of Higher Education (MAHE), Manipal, India and Dr. KK Mahato, HoD, Department of Biophysics, MSLS, MAHE, Manipal, India for their constant support and guidance. We would also express our sincere gratitude to MAHE, Manipal for providing the infrastructure needed for the study.
Publisher Copyright:
© 2020 Wiley Periodicals LLC
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Severe Acute Respiratory Syndrome Coronaviruses (SARS-CoVs), causative of major outbreaks in the past two decades, has claimed many lives all over the world. The virus effectively spreads through saliva aerosols or nasal discharge from an infected person. Currently, no specific vaccines or treatments exist for coronavirus; however, several attempts are being made to develop possible treatments. Hence, it is important to study the viral structure and life cycle to understand its functionality, activity, and infectious nature. Further, such studies can aid in the development of vaccinations against this virus. Microscopy plays an important role in examining the structure and topology of the virus as well as pathogenesis in infected host cells. This review deals with different microscopy techniques including electron microscopy, atomic force microscopy, fluorescence microscopy as well as computational methods to elucidate various prospects of this life-threatening virus.
AB - Severe Acute Respiratory Syndrome Coronaviruses (SARS-CoVs), causative of major outbreaks in the past two decades, has claimed many lives all over the world. The virus effectively spreads through saliva aerosols or nasal discharge from an infected person. Currently, no specific vaccines or treatments exist for coronavirus; however, several attempts are being made to develop possible treatments. Hence, it is important to study the viral structure and life cycle to understand its functionality, activity, and infectious nature. Further, such studies can aid in the development of vaccinations against this virus. Microscopy plays an important role in examining the structure and topology of the virus as well as pathogenesis in infected host cells. This review deals with different microscopy techniques including electron microscopy, atomic force microscopy, fluorescence microscopy as well as computational methods to elucidate various prospects of this life-threatening virus.
UR - http://www.scopus.com/inward/record.url?scp=85089074983&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85089074983&partnerID=8YFLogxK
U2 - 10.1002/jemt.23551
DO - 10.1002/jemt.23551
M3 - Review article
AN - SCOPUS:85089074983
SN - 1059-910X
VL - 83
SP - 1623
EP - 1638
JO - Microscopy Research and Technique
JF - Microscopy Research and Technique
IS - 12
ER -
