Emerging era of “somes”: polymersomes as versatile drug delivery carrier for cancer diagnostics and therapy

Abhishek Kumar Sharma, Parteek Prasher, Alaa A. Aljabali, Vijay Mishra, Himanshu Gandhi, Sunil Kumar, Srinivas Mutalik, Dinesh Kumar Chellappan, Murtaza M. Tambuwala, Kamal Dua, Deepak N. Kapoor

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Over the past two decades, polymersomes have been widely investigated for the delivery of diagnostic and therapeutic agents in cancer therapy. Polymersomes are stable polymeric vesicles, which are prepared using amphiphilic block polymers of different molecular weights. The use of high molecular weight amphiphilic copolymers allows for possible manipulation of membrane characteristics, which in turn enhances the efficiency of drug delivery. Polymersomes are more stable in comparison with liposomes and show less toxicity in vivo. Furthermore, their ability to encapsulate both hydrophilic and hydrophobic drugs, significant biocompatibility, robustness, high colloidal stability, and simple methods for ligands conjugation make polymersomes a promising candidate for therapeutic drug delivery in cancer therapy. This review is focused on current development in the application of polymersomes for cancer therapy and diagnosis. [Figure not available: see fulltext.].

Original languageEnglish
JournalDrug Delivery and Translational Research
DOIs
Publication statusAccepted/In press - 01-01-2020

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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