Enantiomeric recognition and separation by chiral nanoparticles

Ankur Gogoi, Nirmal Mazumder, Surajit Konwer, Harsh Ranawat, Nai Tzu Chen, Guan Yu Zhuo

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Chiral molecules are stereoselective with regard to specific biological functions. Enantiomers differ considerably in their physiological reactions with the human body. Safeguarding the quality and safety of drugs requires an efficient analytical platform by which to selectively probe chiral compounds to ensure the extraction of single enantiomers. Asymmetric synthesis is a mature approach to the production of single enantiomers; however, it is poorly suited to mass production and allows for only specific enantioselective reactions. Furthermore, it is too expensive and time-consuming for the evaluation of therapeutic drugs in the early stages of development. These limitations have prompted the development of surface-modified nanoparticles using amino acids, chiral organic ligands, or functional groups as chiral selectors applicable to a racemic mixture of chiral molecules. The fact that these combinations can be optimized in terms of sensitivity, specificity, and enantioselectivity makes them ideal for enantiomeric recognition and separation. In chiral resolution, molecules bond selectively to particle surfaces according to homochiral interactions, whereupon an enantiopure compound is extracted from the solution through a simple filtration process. In this review article, we discuss the fabrication of chiral nanoparticles and look at the ways their distinctive surface properties have been adopted in enantiomeric recognition and separation.

Original languageEnglish
Article number1007
JournalMolecules
Volume24
Issue number6
DOIs
Publication statusPublished - 01-01-2019

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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  • Cite this

    Gogoi, A., Mazumder, N., Konwer, S., Ranawat, H., Chen, N. T., & Zhuo, G. Y. (2019). Enantiomeric recognition and separation by chiral nanoparticles. Molecules, 24(6), [1007]. https://doi.org/10.3390/molecules24061007