Enantioselective Michael addition of malonic esters to benzalacetophenone by using chiral phase transfer catalysts derived from proline-mandelic acid/tartaric acid

Deepak P. Mahajan, Himanshu M. Godbole, Girij P. Singh, Gautham G. Shenoy

Research output: Contribution to journalArticle

Abstract

Abstract: Herein, we have explored the enantioselective Michael addition of various malonate esters to benzalacetophenone by successful utilization of chiral phase transfer catalysts derived from proline, mandelic acid and tartaric acid under mild phase transfer conditions. The obtained results signify that these chiral phase transfer catalysts are efficacious towards enantioselective Michael addition as the use of it resulted in good enantioselectivity and appreciable chemical yields. Graphic Abstract: SYNOPSIS Highly enantioselective Michael addition of dialkyl malonates to benzalacetophenone has been established under mild phase transfer conditions, by successful utilization of chiral phase transfer catalysts derived from proline, mandelic acid and tartaric acid (I–VI) with appreciable chemical yields.[Figure not available: see fulltext.].

Original languageEnglish
Article number67
JournalJournal of Chemical Sciences
Volume131
Issue number7
DOIs
Publication statusPublished - 01-07-2019

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Chalcone
Proline
Esters
Catalysts
Malonates
Enantioselectivity
mandelic acid
tartaric acid

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

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title = "Enantioselective Michael addition of malonic esters to benzalacetophenone by using chiral phase transfer catalysts derived from proline-mandelic acid/tartaric acid",
abstract = "Abstract: Herein, we have explored the enantioselective Michael addition of various malonate esters to benzalacetophenone by successful utilization of chiral phase transfer catalysts derived from proline, mandelic acid and tartaric acid under mild phase transfer conditions. The obtained results signify that these chiral phase transfer catalysts are efficacious towards enantioselective Michael addition as the use of it resulted in good enantioselectivity and appreciable chemical yields. Graphic Abstract: SYNOPSIS Highly enantioselective Michael addition of dialkyl malonates to benzalacetophenone has been established under mild phase transfer conditions, by successful utilization of chiral phase transfer catalysts derived from proline, mandelic acid and tartaric acid (I–VI) with appreciable chemical yields.[Figure not available: see fulltext.].",
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Enantioselective Michael addition of malonic esters to benzalacetophenone by using chiral phase transfer catalysts derived from proline-mandelic acid/tartaric acid. / Mahajan, Deepak P.; Godbole, Himanshu M.; Singh, Girij P.; Shenoy, Gautham G.

In: Journal of Chemical Sciences, Vol. 131, No. 7, 67, 01.07.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Enantioselective Michael addition of malonic esters to benzalacetophenone by using chiral phase transfer catalysts derived from proline-mandelic acid/tartaric acid

AU - Mahajan, Deepak P.

AU - Godbole, Himanshu M.

AU - Singh, Girij P.

AU - Shenoy, Gautham G.

PY - 2019/7/1

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N2 - Abstract: Herein, we have explored the enantioselective Michael addition of various malonate esters to benzalacetophenone by successful utilization of chiral phase transfer catalysts derived from proline, mandelic acid and tartaric acid under mild phase transfer conditions. The obtained results signify that these chiral phase transfer catalysts are efficacious towards enantioselective Michael addition as the use of it resulted in good enantioselectivity and appreciable chemical yields. Graphic Abstract: SYNOPSIS Highly enantioselective Michael addition of dialkyl malonates to benzalacetophenone has been established under mild phase transfer conditions, by successful utilization of chiral phase transfer catalysts derived from proline, mandelic acid and tartaric acid (I–VI) with appreciable chemical yields.[Figure not available: see fulltext.].

AB - Abstract: Herein, we have explored the enantioselective Michael addition of various malonate esters to benzalacetophenone by successful utilization of chiral phase transfer catalysts derived from proline, mandelic acid and tartaric acid under mild phase transfer conditions. The obtained results signify that these chiral phase transfer catalysts are efficacious towards enantioselective Michael addition as the use of it resulted in good enantioselectivity and appreciable chemical yields. Graphic Abstract: SYNOPSIS Highly enantioselective Michael addition of dialkyl malonates to benzalacetophenone has been established under mild phase transfer conditions, by successful utilization of chiral phase transfer catalysts derived from proline, mandelic acid and tartaric acid (I–VI) with appreciable chemical yields.[Figure not available: see fulltext.].

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