Endothelins: Their current status and future prospects

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Abstract

Endothelins are potent peptide vasoconstrictors which were discovered two decades back. Their role in cardiovascular diseases, cancer, glaucoma, diabetes mellitus and many other diseases have been studied. Inspite of a lot of research many questions regarding their pathophysiological roles still remain unanswered. Though many endothelin receptor antagonists showed promising results in animal studies they failed to show significant improvement in clinical practice. The limitations of receptor antagonists lead to the research on synthesis inhibitors and their combinations with ACE inhibitors. This article summarizes the path of endothelins from their discovery to their current status and future prospects.

Original languageEnglish
Article number17
Pages (from-to)94-97
Number of pages4
JournalInternational Journal of Pharmaceutical Sciences Review and Research
Volume23
Issue number2
Publication statusPublished - 23-12-2013

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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