Enhanced antitumour efficacy of methotrexate poly(lactic-co-glycolic) acid injectable gel implants in mice bearing sarcoma-180

U. V. Singh, N. Udupa, R. Kamath, P. Umadevi

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Injectable gel implants using poly(lactic-co-glycolic) acid (PLGA) for methotrexate were prepared. In-vitro release was observed for 10-12 days and was dependent on PLGA concentration. The antitumour efficacy in mice bearing sarcoma-180 was improved as revealed by the volume doubling time. The drug plasma levels were sustained for more than 2 weeks.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalPharmaceutical Sciences
Issue number3
Publication statusPublished - 1997


All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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