Enhanced antitumour efficacy of methotrexate poly(lactic-co-glycolic) acid injectable gel implants in mice bearing sarcoma-180

U. V. Singh, N. Udupa, R. Kamath, P. Umadevi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Injectable gel implants using poly(lactic-co-glycolic) acid (PLGA) for methotrexate were prepared. In-vitro release was observed for 10-12 days and was dependent on PLGA concentration. The antitumour efficacy in mice bearing sarcoma-180 was improved as revealed by the volume doubling time. The drug plasma levels were sustained for more than 2 weeks.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalPharmaceutical Sciences
Volume3
Issue number3
Publication statusPublished - 1997

Fingerprint

Sarcoma 180
Methotrexate
Gels
Injections
Pharmaceutical Preparations
polylactic acid-polyglycolic acid copolymer
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

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Enhanced antitumour efficacy of methotrexate poly(lactic-co-glycolic) acid injectable gel implants in mice bearing sarcoma-180. / Singh, U. V.; Udupa, N.; Kamath, R.; Umadevi, P.

In: Pharmaceutical Sciences, Vol. 3, No. 3, 1997, p. 133-136.

Research output: Contribution to journalArticle

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AU - Singh, U. V.

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AU - Umadevi, P.

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