Enhanced fluorescence emission of norfloxacin on complexation with cyclodextrin

K. S. Aithal, K. Nalini, N. Udupa, K. K. Sreenivasan

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Enhanced UV absorption (a=three times) and fluorescence emission (k= four time) was observed for Norfloxacin when it was complexed with Betacyclodextin. This could enhance the precession in the analysis of Norfloxacin by the fluorescence emission method compared to the UV absorption method. The 1:1 M neutralization complex gave maximum values of both UV absorbance and fluorescence emission compared to the physical mixture or the kneading complex. The probable mechanism of the complex formation was proposed to be due to the inclusion of drug into the BCD cavity. The rigidity of the molecule could deactivate the collision, reducing the quenching, leading to an increase in fluorescence. Thus spectro-fluorimetric method is more precise, reproducible and simple in the estimation of Norfloxacin and can be used with higher accuracy for the estimation of Norfloxacin in formulations or biological samples.

Original languageEnglish
Pages (from-to)162-166
Number of pages5
JournalIndian Drugs
Volume42
Issue number3
Publication statusPublished - 03-2005

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

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    Aithal, K. S., Nalini, K., Udupa, N., & Sreenivasan, K. K. (2005). Enhanced fluorescence emission of norfloxacin on complexation with cyclodextrin. Indian Drugs, 42(3), 162-166.