Felodipine exhibits limited oral bioavailability, one reason being cytochrome P 450 substrate. Quercetin is reported in literature as an inhibitor of P-glycoprotein and cytochrome P 450, thereby, improving bioavailability of P-glycoprotein and cytochrome P 450 substrates. A mixture of quercetin and felodipine showed increased permeability of felodipine in a pilot experiment of the present study. Based on these results, an attempt has been made to formulate a dosage form comprising of sugar beads loaded with felodipine along with quercetin coating. The cytochrome P450 3A4 inhibitory effect of quercetin on the permeation of felodipine from the formulation was investigated using Ussing chamber. The beads exhibited 100% felodipine release in dissolution study. The results from ex vivo permeability study suggested that the formulation improved the intestinal permeation of felodipine in presence of quercetin.
|Number of pages||6|
|Journal||Latin American Journal of Pharmacy|
|Publication status||Published - 2016|
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
- Drug Discovery