Enhanced intestinal permeability of quercetin coated felodipine beads in wistar rats. Formulation and Ex Vivo study

Amita Bhandari, Zenab Attari, Prashant Musmade, Shaila Lewis

Research output: Contribution to journalArticle

Abstract

Felodipine exhibits limited oral bioavailability, one reason being cytochrome P 450 substrate. Quercetin is reported in literature as an inhibitor of P-glycoprotein and cytochrome P 450, thereby, improving bioavailability of P-glycoprotein and cytochrome P 450 substrates. A mixture of quercetin and felodipine showed increased permeability of felodipine in a pilot experiment of the present study. Based on these results, an attempt has been made to formulate a dosage form comprising of sugar beads loaded with felodipine along with quercetin coating. The cytochrome P450 3A4 inhibitory effect of quercetin on the permeation of felodipine from the formulation was investigated using Ussing chamber. The beads exhibited 100% felodipine release in dissolution study. The results from ex vivo permeability study suggested that the formulation improved the intestinal permeation of felodipine in presence of quercetin.

Original languageEnglish
Pages (from-to)558-563
Number of pages6
JournalLatin American Journal of Pharmacy
Volume35
Issue number3
Publication statusPublished - 2016

Fingerprint

Felodipine
Quercetin
Wistar Rats
Permeability
Cytochrome P-450 Enzyme System
P-Glycoprotein
Biological Availability
Cytochrome P-450 CYP3A
Dosage Forms

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Drug Discovery

Cite this

@article{393e0b9d74a34fcdb5d06953e9be4c3f,
title = "Enhanced intestinal permeability of quercetin coated felodipine beads in wistar rats. Formulation and Ex Vivo study",
abstract = "Felodipine exhibits limited oral bioavailability, one reason being cytochrome P 450 substrate. Quercetin is reported in literature as an inhibitor of P-glycoprotein and cytochrome P 450, thereby, improving bioavailability of P-glycoprotein and cytochrome P 450 substrates. A mixture of quercetin and felodipine showed increased permeability of felodipine in a pilot experiment of the present study. Based on these results, an attempt has been made to formulate a dosage form comprising of sugar beads loaded with felodipine along with quercetin coating. The cytochrome P450 3A4 inhibitory effect of quercetin on the permeation of felodipine from the formulation was investigated using Ussing chamber. The beads exhibited 100{\%} felodipine release in dissolution study. The results from ex vivo permeability study suggested that the formulation improved the intestinal permeation of felodipine in presence of quercetin.",
author = "Amita Bhandari and Zenab Attari and Prashant Musmade and Shaila Lewis",
note = "cited By 0",
year = "2016",
language = "English",
volume = "35",
pages = "558--563",
journal = "Latin American Journal of Pharmacy",
issn = "0326-2383",
publisher = "Colegio de Farmaceuticos de la Provincia de Buenos Aires",
number = "3",

}

Enhanced intestinal permeability of quercetin coated felodipine beads in wistar rats. Formulation and Ex Vivo study. / Bhandari, Amita; Attari, Zenab; Musmade, Prashant; Lewis, Shaila.

In: Latin American Journal of Pharmacy, Vol. 35, No. 3, 2016, p. 558-563.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Enhanced intestinal permeability of quercetin coated felodipine beads in wistar rats. Formulation and Ex Vivo study

AU - Bhandari, Amita

AU - Attari, Zenab

AU - Musmade, Prashant

AU - Lewis, Shaila

N1 - cited By 0

PY - 2016

Y1 - 2016

N2 - Felodipine exhibits limited oral bioavailability, one reason being cytochrome P 450 substrate. Quercetin is reported in literature as an inhibitor of P-glycoprotein and cytochrome P 450, thereby, improving bioavailability of P-glycoprotein and cytochrome P 450 substrates. A mixture of quercetin and felodipine showed increased permeability of felodipine in a pilot experiment of the present study. Based on these results, an attempt has been made to formulate a dosage form comprising of sugar beads loaded with felodipine along with quercetin coating. The cytochrome P450 3A4 inhibitory effect of quercetin on the permeation of felodipine from the formulation was investigated using Ussing chamber. The beads exhibited 100% felodipine release in dissolution study. The results from ex vivo permeability study suggested that the formulation improved the intestinal permeation of felodipine in presence of quercetin.

AB - Felodipine exhibits limited oral bioavailability, one reason being cytochrome P 450 substrate. Quercetin is reported in literature as an inhibitor of P-glycoprotein and cytochrome P 450, thereby, improving bioavailability of P-glycoprotein and cytochrome P 450 substrates. A mixture of quercetin and felodipine showed increased permeability of felodipine in a pilot experiment of the present study. Based on these results, an attempt has been made to formulate a dosage form comprising of sugar beads loaded with felodipine along with quercetin coating. The cytochrome P450 3A4 inhibitory effect of quercetin on the permeation of felodipine from the formulation was investigated using Ussing chamber. The beads exhibited 100% felodipine release in dissolution study. The results from ex vivo permeability study suggested that the formulation improved the intestinal permeation of felodipine in presence of quercetin.

UR - http://www.scopus.com/inward/record.url?scp=84961184355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961184355&partnerID=8YFLogxK

M3 - Article

VL - 35

SP - 558

EP - 563

JO - Latin American Journal of Pharmacy

JF - Latin American Journal of Pharmacy

SN - 0326-2383

IS - 3

ER -