Enhancement of dissolution of glipizide from controlled porosity osmotic pump using a wicking agent and a solubilizing agent

R. Mahalaxmi, P. Sastri, Ravikumar [No Value], A. Kalra, P. Kanagale D, R. Narkhede

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Extended release controlled porosity osmotic pump formulations of model drug glipizide were developed using a wicking agent and a solubilizing agent. Glipizide osmotic tablets were evaluated for their flow properties, weight variation, hardness, friability and content uniformity. The effect of different formulation variables like level of wicking agent, solubilizing agent, level of pore former and membrane weight gain on in vitro release were studied. Drug release was found to be affected by the level of wicking agent and solubilizing agent in the core. Glipizide release from controlled porosity osmotic pump was directly proportional to the pore former (sorbitol) and inversely proportional to membrane weight gain. Drug release from the developed formulations was independent of pH and agitational intensity and was dependent on osmotic pressure of the release media. The optimized formulation was also found to stable upon stability studies.
Original languageEnglish
Pages (from-to)705-711
Number of pages7
JournalInternational Journal of PharmTech Research
Volume1
Issue number3
Publication statusPublished - 2009

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Glipizide
Capillary Action
Porosity
Weight Gain
Drug Compounding
Membranes
Sorbitol
Osmotic Pressure
Hardness
Tablets
Weights and Measures
Drug Liberation

Cite this

Mahalaxmi, R. ; Sastri, P. ; [No Value], Ravikumar ; Kalra, A. ; Kanagale D, P. ; Narkhede, R. / Enhancement of dissolution of glipizide from controlled porosity osmotic pump using a wicking agent and a solubilizing agent. In: International Journal of PharmTech Research. 2009 ; Vol. 1, No. 3. pp. 705-711.
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title = "Enhancement of dissolution of glipizide from controlled porosity osmotic pump using a wicking agent and a solubilizing agent",
abstract = "Extended release controlled porosity osmotic pump formulations of model drug glipizide were developed using a wicking agent and a solubilizing agent. Glipizide osmotic tablets were evaluated for their flow properties, weight variation, hardness, friability and content uniformity. The effect of different formulation variables like level of wicking agent, solubilizing agent, level of pore former and membrane weight gain on in vitro release were studied. Drug release was found to be affected by the level of wicking agent and solubilizing agent in the core. Glipizide release from controlled porosity osmotic pump was directly proportional to the pore former (sorbitol) and inversely proportional to membrane weight gain. Drug release from the developed formulations was independent of pH and agitational intensity and was dependent on osmotic pressure of the release media. The optimized formulation was also found to stable upon stability studies.",
author = "R. Mahalaxmi and P. Sastri and {[No Value]}, Ravikumar and A. Kalra and {Kanagale D}, P. and R. Narkhede",
note = "Cited By :11 Export Date: 10 November 2017 Correspondence Address: Mahalaxmi, R.; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal, India; email: mlrcops2002@yahoo.co.in Chemicals/CAS: cellulose acetate, 9004-35-7; dodecyl sulfate sodium, 151-21-3; glipizide, 29094-61-9; magnesium stearate, 557-04-0; mannitol, 69-65-8, 87-78-5; povidone, 9003-39-8; sorbitol, 26566-34-7, 50-70-4, 53469-19-5; trometamol, 1185-53-1, 77-86-1 Manufacturers: Zydus Research Center References: Chien, Y.W., Potential developments and new approaches in Oral Controlled-release Drug Delivery Systems (1983) Drug Dev Ind Pharm, 9, pp. 1291-1330; Sastry, S.V., Nyshadham, J.R., Fix, J.A., Recent technological advances in Oral Drug Delivery - A Review (2002) Pharm Sci Technol Today, 3, pp. 138-145; Ritschel, W.A., Bio-pharmaceutics and Pharmacokinetics aspects in the design of Controlled release per-oral Drug Delivery Systems (1989) Drug Dev Ind Pharm, 15, pp. 1073-1083; Zentner, G.M., Rork, G.S., Himmelstein, K.I., Osmotic Flow through Controlled Porosity Films: An approach to delivery of water-soluble compounds (1985) PharmTechnol, 5, pp. 35-44; Theeuwes, F., Drug delivery systems (1981) Pharm Ther, 13, pp. 149-191; Eckenhoff, B., Theeuwes, F., Urquhart, J., Osmotically activated dosage forms for rate controlled drug delivery (1981) Pharm Technol, 5, pp. 35-44; Eckenhoff, B., Yum, S.I., The Osmotic pump -Novel research tool for optimizing drug regimens (1981) Biomaterials, 2, pp. 89-97; Verma, K.R., Krishna, D.M., Garg, S., Review - Formulation aspects in the development of Osmotically Controlled Oral drug delivery systems (2002) J Control Rel, 79, pp. 7-27; Singh, P., Sihorkar, V., Mishra, V., Saravanababu, B., Venketatan, N., Vyas, S.P., Osmotic pumps: From present view to newer perspectives in Pharmaceutical Industry (1999) Eastern Pharmacist, 502, pp. 39-46; Hite M, Turner S, Fedrici C. Oral delivery of poorly soluble drugs, part 1 &2, PMPS summer., 2003: 38-40; Bhat P.Osmotic drug delivery systems for poorly soluble drugs, the drug delivery companies report @ Pharma ventures Ltd., 2004; Adel Aly, M., Mazen Qato, K., Mahrous Ahmad, O., Enhancement of the dissolution rate and bioavailability of glipizide through cyclodextrin inclusion complex (2002) Drug Del Ind Pharm, 32, pp. 578-584; Sapna Makhija, N., Pradeep Vavia, R., Controlled Porosity Osmotic Pump- based Controlled Release Systems of Pseudo ephedrine - Cellulose acetate as a semi-permeable membrane (2003) J Control Rel, 89, pp. 5-18; Verma, K.R., Garg, S., Development and Evaluation of Osmotically Controlled Oral Drug Delivery System of Glipizide (2004) Eur J Pharm Biopharm, 57, pp. 513-525; Verma, K.R., Kaushal, M.A., Garg, S., Development and Evaluation of Extended Release Formulations of Iso-sorbide MonoNitrate based on Osmotic Technology (2003) Int J Pharm, 263, pp. 9-24; Verma, R.K., Mishra, B., Studies on Formulation and Evaluation of oral osmotic pumps of Nimesulide (1999) Pharmazie, 54, pp. 74-75; Coata, P., Lobo, J.M., Modeling and Comparison of Dissolution Profiles (2001) Eur J Pharm Sci, 13, pp. 123-133; Rudnic, E.M., Beth, B.M., Jill, E.P., Osmotic Drug Delivery System (2002), U.S. Patent, 6:110,498; Rudnic, E.M., Beth, B.M., Jill, E.P., Soluble form Osmotic dose delivery System (2001), U.S. Patent, 6:284,276; Mc Clelland, G.A., Sutton, S.C., Engle, K., Zenter, G.M., The Solubility modulated Osmotic Pump: In-vitro/In-vivo release of Diltizeam Hydro chloride (1991) Pharma Res, 8, pp. 88-92; Verma, R.K., Mishra, B., Garg, S., Osmotically Controlled Oral Drug Delivery (2000) Drug Del Ind Pharm, 26, pp. 695-708; Thombre, G., Cardinal, J.R., DeNoto, A.R., Herbig, S.M., Smith, K.L., Asymmetric Membrane Capsules for Osmotic Drug delivery I. Development of a Manufacturing Process J Control Rel, 199 (57), pp. 55-64; Gabr, K.E., Borg, M.E., Characterization of Hydro chloro Thiazide-Trometamol Mixture: Formulation of Fast Release and Soluble Tablet (1999) Pharmaz Ind, 61, pp. 281-285; El-Sayed, G.M., Role of Tromethamine as a Dissolution and Bioavailability enhancer of Oral Glibencamide (1998) STP Pharma Sci, 8, pp. 169-173; Gaylen Zentner, N.I., Gerald Rork, S., Kenneth Himmelstein, J., The Controlled Porosity Osmotic Pump utilizing solubility modulated and resin modulated approach (1991) J Control Rel, 1, pp. 269-282; Jensen, J.L., Appel, L.E., Chair, J.H., Zenter, G.M., Variables that Effect the Mechanism of drug release from Osmotic Pumps coated with Acrylate/Methacrylate copolymer Latexes (1995) J. Pharma. Sci, 84, pp. 530-533",
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Enhancement of dissolution of glipizide from controlled porosity osmotic pump using a wicking agent and a solubilizing agent. / Mahalaxmi, R.; Sastri, P.; [No Value], Ravikumar; Kalra, A.; Kanagale D, P.; Narkhede, R.

In: International Journal of PharmTech Research, Vol. 1, No. 3, 2009, p. 705-711.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Enhancement of dissolution of glipizide from controlled porosity osmotic pump using a wicking agent and a solubilizing agent

AU - Mahalaxmi, R.

AU - Sastri, P.

AU - [No Value], Ravikumar

AU - Kalra, A.

AU - Kanagale D, P.

AU - Narkhede, R.

N1 - Cited By :11 Export Date: 10 November 2017 Correspondence Address: Mahalaxmi, R.; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal, India; email: mlrcops2002@yahoo.co.in Chemicals/CAS: cellulose acetate, 9004-35-7; dodecyl sulfate sodium, 151-21-3; glipizide, 29094-61-9; magnesium stearate, 557-04-0; mannitol, 69-65-8, 87-78-5; povidone, 9003-39-8; sorbitol, 26566-34-7, 50-70-4, 53469-19-5; trometamol, 1185-53-1, 77-86-1 Manufacturers: Zydus Research Center References: Chien, Y.W., Potential developments and new approaches in Oral Controlled-release Drug Delivery Systems (1983) Drug Dev Ind Pharm, 9, pp. 1291-1330; Sastry, S.V., Nyshadham, J.R., Fix, J.A., Recent technological advances in Oral Drug Delivery - A Review (2002) Pharm Sci Technol Today, 3, pp. 138-145; Ritschel, W.A., Bio-pharmaceutics and Pharmacokinetics aspects in the design of Controlled release per-oral Drug Delivery Systems (1989) Drug Dev Ind Pharm, 15, pp. 1073-1083; Zentner, G.M., Rork, G.S., Himmelstein, K.I., Osmotic Flow through Controlled Porosity Films: An approach to delivery of water-soluble compounds (1985) PharmTechnol, 5, pp. 35-44; Theeuwes, F., Drug delivery systems (1981) Pharm Ther, 13, pp. 149-191; Eckenhoff, B., Theeuwes, F., Urquhart, J., Osmotically activated dosage forms for rate controlled drug delivery (1981) Pharm Technol, 5, pp. 35-44; Eckenhoff, B., Yum, S.I., The Osmotic pump -Novel research tool for optimizing drug regimens (1981) Biomaterials, 2, pp. 89-97; Verma, K.R., Krishna, D.M., Garg, S., Review - Formulation aspects in the development of Osmotically Controlled Oral drug delivery systems (2002) J Control Rel, 79, pp. 7-27; Singh, P., Sihorkar, V., Mishra, V., Saravanababu, B., Venketatan, N., Vyas, S.P., Osmotic pumps: From present view to newer perspectives in Pharmaceutical Industry (1999) Eastern Pharmacist, 502, pp. 39-46; Hite M, Turner S, Fedrici C. Oral delivery of poorly soluble drugs, part 1 &2, PMPS summer., 2003: 38-40; Bhat P.Osmotic drug delivery systems for poorly soluble drugs, the drug delivery companies report @ Pharma ventures Ltd., 2004; Adel Aly, M., Mazen Qato, K., Mahrous Ahmad, O., Enhancement of the dissolution rate and bioavailability of glipizide through cyclodextrin inclusion complex (2002) Drug Del Ind Pharm, 32, pp. 578-584; Sapna Makhija, N., Pradeep Vavia, R., Controlled Porosity Osmotic Pump- based Controlled Release Systems of Pseudo ephedrine - Cellulose acetate as a semi-permeable membrane (2003) J Control Rel, 89, pp. 5-18; Verma, K.R., Garg, S., Development and Evaluation of Osmotically Controlled Oral Drug Delivery System of Glipizide (2004) Eur J Pharm Biopharm, 57, pp. 513-525; Verma, K.R., Kaushal, M.A., Garg, S., Development and Evaluation of Extended Release Formulations of Iso-sorbide MonoNitrate based on Osmotic Technology (2003) Int J Pharm, 263, pp. 9-24; Verma, R.K., Mishra, B., Studies on Formulation and Evaluation of oral osmotic pumps of Nimesulide (1999) Pharmazie, 54, pp. 74-75; Coata, P., Lobo, J.M., Modeling and Comparison of Dissolution Profiles (2001) Eur J Pharm Sci, 13, pp. 123-133; Rudnic, E.M., Beth, B.M., Jill, E.P., Osmotic Drug Delivery System (2002), U.S. Patent, 6:110,498; Rudnic, E.M., Beth, B.M., Jill, E.P., Soluble form Osmotic dose delivery System (2001), U.S. Patent, 6:284,276; Mc Clelland, G.A., Sutton, S.C., Engle, K., Zenter, G.M., The Solubility modulated Osmotic Pump: In-vitro/In-vivo release of Diltizeam Hydro chloride (1991) Pharma Res, 8, pp. 88-92; Verma, R.K., Mishra, B., Garg, S., Osmotically Controlled Oral Drug Delivery (2000) Drug Del Ind Pharm, 26, pp. 695-708; Thombre, G., Cardinal, J.R., DeNoto, A.R., Herbig, S.M., Smith, K.L., Asymmetric Membrane Capsules for Osmotic Drug delivery I. Development of a Manufacturing Process J Control Rel, 199 (57), pp. 55-64; Gabr, K.E., Borg, M.E., Characterization of Hydro chloro Thiazide-Trometamol Mixture: Formulation of Fast Release and Soluble Tablet (1999) Pharmaz Ind, 61, pp. 281-285; El-Sayed, G.M., Role of Tromethamine as a Dissolution and Bioavailability enhancer of Oral Glibencamide (1998) STP Pharma Sci, 8, pp. 169-173; Gaylen Zentner, N.I., Gerald Rork, S., Kenneth Himmelstein, J., The Controlled Porosity Osmotic Pump utilizing solubility modulated and resin modulated approach (1991) J Control Rel, 1, pp. 269-282; Jensen, J.L., Appel, L.E., Chair, J.H., Zenter, G.M., Variables that Effect the Mechanism of drug release from Osmotic Pumps coated with Acrylate/Methacrylate copolymer Latexes (1995) J. Pharma. Sci, 84, pp. 530-533

PY - 2009

Y1 - 2009

N2 - Extended release controlled porosity osmotic pump formulations of model drug glipizide were developed using a wicking agent and a solubilizing agent. Glipizide osmotic tablets were evaluated for their flow properties, weight variation, hardness, friability and content uniformity. The effect of different formulation variables like level of wicking agent, solubilizing agent, level of pore former and membrane weight gain on in vitro release were studied. Drug release was found to be affected by the level of wicking agent and solubilizing agent in the core. Glipizide release from controlled porosity osmotic pump was directly proportional to the pore former (sorbitol) and inversely proportional to membrane weight gain. Drug release from the developed formulations was independent of pH and agitational intensity and was dependent on osmotic pressure of the release media. The optimized formulation was also found to stable upon stability studies.

AB - Extended release controlled porosity osmotic pump formulations of model drug glipizide were developed using a wicking agent and a solubilizing agent. Glipizide osmotic tablets were evaluated for their flow properties, weight variation, hardness, friability and content uniformity. The effect of different formulation variables like level of wicking agent, solubilizing agent, level of pore former and membrane weight gain on in vitro release were studied. Drug release was found to be affected by the level of wicking agent and solubilizing agent in the core. Glipizide release from controlled porosity osmotic pump was directly proportional to the pore former (sorbitol) and inversely proportional to membrane weight gain. Drug release from the developed formulations was independent of pH and agitational intensity and was dependent on osmotic pressure of the release media. The optimized formulation was also found to stable upon stability studies.

M3 - Article

VL - 1

SP - 705

EP - 711

JO - International Journal of PharmTech Research

JF - International Journal of PharmTech Research

SN - 0974-4304

IS - 3

ER -