Enhancement of micronuclei frequency by vindesine in mouse bone marrow

Ganesh Chandra Jagetia; P. Jyothi

doi:10.1016/S1383-5718(96)00094-0

Enhancement of micronuclei frequency by vindesine in mouse bone marrow

Ganesh Chandra Jagetia, P. Jyothi

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Treatment of mice with various doses (0, 0.25, 0.5, 1.0 and 2.0 mg/kg b.wt.) of vindesine resulted in a dose-dependent increase in the frequency of micronucleated polychromatic erythrocytes (MPCE) and micronucleated normochromatic erythrocytes. Conversely, the polychromatic erythrocyte and normochromatic erythrocyte (P/N ratio) ratio declined with increasing dose of vindesine. The dose effect relationship for MPCE, MNCE and P/N ratio was linear quadratic.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Mutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume	388
Issue number	1
DOIs	https://doi.org/10.1016/S1383-5718(96)00094-0
Publication status	Published - 15-01-1997
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics
Health, Toxicology and Mutagenesis

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10.1016/S1383-5718(96)00094-0

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abstract = "Treatment of mice with various doses (0, 0.25, 0.5, 1.0 and 2.0 mg/kg b.wt.) of vindesine resulted in a dose-dependent increase in the frequency of micronucleated polychromatic erythrocytes (MPCE) and micronucleated normochromatic erythrocytes. Conversely, the polychromatic erythrocyte and normochromatic erythrocyte (P/N ratio) ratio declined with increasing dose of vindesine. The dose effect relationship for MPCE, MNCE and P/N ratio was linear quadratic.",

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AU - Jyothi, P.

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N2 - Treatment of mice with various doses (0, 0.25, 0.5, 1.0 and 2.0 mg/kg b.wt.) of vindesine resulted in a dose-dependent increase in the frequency of micronucleated polychromatic erythrocytes (MPCE) and micronucleated normochromatic erythrocytes. Conversely, the polychromatic erythrocyte and normochromatic erythrocyte (P/N ratio) ratio declined with increasing dose of vindesine. The dose effect relationship for MPCE, MNCE and P/N ratio was linear quadratic.

AB - Treatment of mice with various doses (0, 0.25, 0.5, 1.0 and 2.0 mg/kg b.wt.) of vindesine resulted in a dose-dependent increase in the frequency of micronucleated polychromatic erythrocytes (MPCE) and micronucleated normochromatic erythrocytes. Conversely, the polychromatic erythrocyte and normochromatic erythrocyte (P/N ratio) ratio declined with increasing dose of vindesine. The dose effect relationship for MPCE, MNCE and P/N ratio was linear quadratic.

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Enhancement of micronuclei frequency by vindesine in mouse bone marrow

Abstract

All Science Journal Classification (ASJC) codes

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