Enhancement of micronuclei frequency by vindesine in mouse bone marrow

Ganesh Chandra Jagetia, P. Jyothi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Treatment of mice with various doses (0, 0.25, 0.5, 1.0 and 2.0 mg/kg b.wt.) of vindesine resulted in a dose-dependent increase in the frequency of micronucleated polychromatic erythrocytes (MPCE) and micronucleated normochromatic erythrocytes. Conversely, the polychromatic erythrocyte and normochromatic erythrocyte (P/N ratio) ratio declined with increasing dose of vindesine. The dose effect relationship for MPCE, MNCE and P/N ratio was linear quadratic.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume388
Issue number1
DOIs
Publication statusPublished - 15-01-1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Health, Toxicology and Mutagenesis

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