Enhancement of micronuclei frequency by vindesine in mouse bone marrow

Ganesh Chandra Jagetia, P. Jyothi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Treatment of mice with various doses (0, 0.25, 0.5, 1.0 and 2.0 mg/kg b.wt.) of vindesine resulted in a dose-dependent increase in the frequency of micronucleated polychromatic erythrocytes (MPCE) and micronucleated normochromatic erythrocytes. Conversely, the polychromatic erythrocyte and normochromatic erythrocyte (P/N ratio) ratio declined with increasing dose of vindesine. The dose effect relationship for MPCE, MNCE and P/N ratio was linear quadratic.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume388
Issue number1
DOIs
Publication statusPublished - 15-01-1997
Externally publishedYes

Fingerprint

Vindesine
Erythrocytes
Bone Marrow

All Science Journal Classification (ASJC) codes

  • Genetics
  • Health, Toxicology and Mutagenesis

Cite this

@article{d31be7dbf80b4b769bc63a9dcac4bc27,
title = "Enhancement of micronuclei frequency by vindesine in mouse bone marrow",
abstract = "Treatment of mice with various doses (0, 0.25, 0.5, 1.0 and 2.0 mg/kg b.wt.) of vindesine resulted in a dose-dependent increase in the frequency of micronucleated polychromatic erythrocytes (MPCE) and micronucleated normochromatic erythrocytes. Conversely, the polychromatic erythrocyte and normochromatic erythrocyte (P/N ratio) ratio declined with increasing dose of vindesine. The dose effect relationship for MPCE, MNCE and P/N ratio was linear quadratic.",
author = "Jagetia, {Ganesh Chandra} and P. Jyothi",
year = "1997",
month = "1",
day = "15",
doi = "10.1016/S1383-5718(96)00094-0",
language = "English",
volume = "388",
pages = "1--5",
journal = "Mutation Research - Genetic Toxicology and Environmental Mutagenesis",
issn = "1383-5718",
publisher = "Elsevier",
number = "1",

}

Enhancement of micronuclei frequency by vindesine in mouse bone marrow. / Jagetia, Ganesh Chandra; Jyothi, P.

In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Vol. 388, No. 1, 15.01.1997, p. 1-5.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Enhancement of micronuclei frequency by vindesine in mouse bone marrow

AU - Jagetia, Ganesh Chandra

AU - Jyothi, P.

PY - 1997/1/15

Y1 - 1997/1/15

N2 - Treatment of mice with various doses (0, 0.25, 0.5, 1.0 and 2.0 mg/kg b.wt.) of vindesine resulted in a dose-dependent increase in the frequency of micronucleated polychromatic erythrocytes (MPCE) and micronucleated normochromatic erythrocytes. Conversely, the polychromatic erythrocyte and normochromatic erythrocyte (P/N ratio) ratio declined with increasing dose of vindesine. The dose effect relationship for MPCE, MNCE and P/N ratio was linear quadratic.

AB - Treatment of mice with various doses (0, 0.25, 0.5, 1.0 and 2.0 mg/kg b.wt.) of vindesine resulted in a dose-dependent increase in the frequency of micronucleated polychromatic erythrocytes (MPCE) and micronucleated normochromatic erythrocytes. Conversely, the polychromatic erythrocyte and normochromatic erythrocyte (P/N ratio) ratio declined with increasing dose of vindesine. The dose effect relationship for MPCE, MNCE and P/N ratio was linear quadratic.

UR - http://www.scopus.com/inward/record.url?scp=0002067146&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0002067146&partnerID=8YFLogxK

U2 - 10.1016/S1383-5718(96)00094-0

DO - 10.1016/S1383-5718(96)00094-0

M3 - Article

VL - 388

SP - 1

EP - 5

JO - Mutation Research - Genetic Toxicology and Environmental Mutagenesis

JF - Mutation Research - Genetic Toxicology and Environmental Mutagenesis

SN - 1383-5718

IS - 1

ER -