Epigenetics mechanisms and degenerative diseases

Joshi K, Smitha Bhat, Deshpande P, Sule M, Satyamoorthy Kapaettu

    Research output: Contribution to journalArticle

    Abstract


    Epigenetic regulations are heritable changes in gene expression that occur in the absence of alterations in DNA sequences. Various epigenetic mechanisms in- clude histone modifications and DNA methylations. In this review, we examine methods to study DNA methylations and their contribution to degenerative diseases by mediating the complex gene-by-environ- ment interactions. Such epigenetic modifications des- pite being heritable and stably maintained are also potentially reversible and there is scope for the de-velopment of epigenetic therapies for this disease
    Original languageEnglish
    JournalOpen Journal of Genetics
    Publication statusPublished - 2012

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    Epigenomics
    DNA Methylation
    Histone Code
    Gene-Environment Interaction
    Gene Expression
    Therapeutics

    Cite this

    K, Joshi ; Bhat, Smitha ; P, Deshpande ; M, Sule ; Kapaettu, Satyamoorthy. / Epigenetics mechanisms and degenerative diseases. In: Open Journal of Genetics. 2012.
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    Epigenetics mechanisms and degenerative diseases. / K, Joshi ; Bhat, Smitha; P, Deshpande ; M, Sule ; Kapaettu, Satyamoorthy.

    In: Open Journal of Genetics, 2012.

    Research output: Contribution to journalArticle

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    T1 - Epigenetics mechanisms and degenerative diseases

    AU - K, Joshi

    AU - Bhat, Smitha

    AU - P, Deshpande

    AU - M, Sule

    AU - Kapaettu, Satyamoorthy

    PY - 2012

    Y1 - 2012

    N2 - Epigenetic regulations are heritable changes in gene expression that occur in the absence of alterations in DNA sequences. Various epigenetic mechanisms in- clude histone modifications and DNA methylations. In this review, we examine methods to study DNA methylations and their contribution to degenerative diseases by mediating the complex gene-by-environ- ment interactions. Such epigenetic modifications des- pite being heritable and stably maintained are also potentially reversible and there is scope for the de-velopment of epigenetic therapies for this disease

    AB - Epigenetic regulations are heritable changes in gene expression that occur in the absence of alterations in DNA sequences. Various epigenetic mechanisms in- clude histone modifications and DNA methylations. In this review, we examine methods to study DNA methylations and their contribution to degenerative diseases by mediating the complex gene-by-environ- ment interactions. Such epigenetic modifications des- pite being heritable and stably maintained are also potentially reversible and there is scope for the de-velopment of epigenetic therapies for this disease

    M3 - Article

    JO - Open Journal of Genetics

    JF - Open Journal of Genetics

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