Erythrocyte antioxidant enzymes and their correlation with malondialdehyde in malaria

Benedicta D'Souza, Vivian D'Souza, H. Swagata, K. Vijayalaxmi, A. S. Namratha

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7 Citations (Scopus)

Abstract

Invasion of human erythrocytes by malaria parasites causes alterations in antioxidant potential of the red cells. The present study was undertaken to investigate the erythrocyte antioxidant enzymes like superoxide dismutase(SOD), catalase(CAT) in malaria patients. Oxidative stress was estimated by measuring malondialdehyde(MDA) which is a marker for lipid peroxidation. 30 malaria patients were enrolled in this study. They were divided into 2 groups of 15 each with Plasmodium vivax malaria and Plasmodium falciparum malaria. Results were compared with 20 healthy control subjects. Significant decrease(p<0.001) in SOD and CAT and increase in MDA (p<0.001) indicates that there is reduction in antioxidant enzymes and increased vulnerability to free radical damage in erythrocytes. This study therefore emphasizes the need for early treatment of malaria patients to reduce the red cell damage.

Original languageEnglish
Pages (from-to)25-27
Number of pages3
JournalBiomedical Research
Volume20
Issue number1
Publication statusPublished - 15-05-2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    D'Souza, B., D'Souza, V., Swagata, H., Vijayalaxmi, K., & Namratha, A. S. (2009). Erythrocyte antioxidant enzymes and their correlation with malondialdehyde in malaria. Biomedical Research, 20(1), 25-27.