Erythrocyte malondialdeyde and antioxidant status in oral squamous cell carcinoma patients and tobacco chewers/smokers

U. Raghavendra, Vivian D'Souza, Benedicta D'Souza

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The aim of this study was to evaluate the levels of lipid peroxidation and antioxidants in the erythrocytes of oral cancer patients and tobacco chewers/smokers. 25 patients with biopsy proven oral squamous cell carcinoma(OSCC), 25 cases of tobacco chewers/smokers and 25 age and sex matched healthy control subjects were included in the study. The levels of malondialdehyde (MDA), a lipid peroxidation marker and antioxidants like superoxide dismutase(SOD) and glutathione(G-SH) were determined by colorimetric methods. Erythrocyte MDA levels were significantly increased (P<0.001) and erythrocyte SOD and G-SH levels were significantly reduced (P<0.001) in OSCC patients compared to control subjects, where as statistically significant increase(P<0.05) in SOD was observed in tobacco chewers/smokers group. There is a negative correlation between MDA and G-SH in OSCC patients and tobacco chewers/smokers. This study shows that there is higher magnitude of oxidative stress in OSCC patients and a weak antioxidant defense system makes the mucosal cells more vulnerable to the genotoxic effect of reactive oxygen species(ROS). A diet rich in antioxidants may alleviate the oxidative stress to some extent.

Original languageEnglish
Pages (from-to)441-444
Number of pages4
JournalBiomedical Research
Volume21
Issue number4
Publication statusPublished - 01-10-2010
Externally publishedYes

Fingerprint

Tobacco
Squamous Cell Carcinoma
Antioxidants
Erythrocytes
Malondialdehyde
Superoxide Dismutase
Oxidative stress
Lipid Peroxidation
Lipids
Oxidative Stress
Biopsy
Smokeless Tobacco
Nutrition
Mouth Neoplasms
Glutathione
Reactive Oxygen Species
Healthy Volunteers
Epithelial Cells
Diet

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Raghavendra, U. ; D'Souza, Vivian ; D'Souza, Benedicta. / Erythrocyte malondialdeyde and antioxidant status in oral squamous cell carcinoma patients and tobacco chewers/smokers. In: Biomedical Research. 2010 ; Vol. 21, No. 4. pp. 441-444.
@article{704a39c611dc43e796bf4afc9771dd83,
title = "Erythrocyte malondialdeyde and antioxidant status in oral squamous cell carcinoma patients and tobacco chewers/smokers",
abstract = "The aim of this study was to evaluate the levels of lipid peroxidation and antioxidants in the erythrocytes of oral cancer patients and tobacco chewers/smokers. 25 patients with biopsy proven oral squamous cell carcinoma(OSCC), 25 cases of tobacco chewers/smokers and 25 age and sex matched healthy control subjects were included in the study. The levels of malondialdehyde (MDA), a lipid peroxidation marker and antioxidants like superoxide dismutase(SOD) and glutathione(G-SH) were determined by colorimetric methods. Erythrocyte MDA levels were significantly increased (P<0.001) and erythrocyte SOD and G-SH levels were significantly reduced (P<0.001) in OSCC patients compared to control subjects, where as statistically significant increase(P<0.05) in SOD was observed in tobacco chewers/smokers group. There is a negative correlation between MDA and G-SH in OSCC patients and tobacco chewers/smokers. This study shows that there is higher magnitude of oxidative stress in OSCC patients and a weak antioxidant defense system makes the mucosal cells more vulnerable to the genotoxic effect of reactive oxygen species(ROS). A diet rich in antioxidants may alleviate the oxidative stress to some extent.",
author = "U. Raghavendra and Vivian D'Souza and Benedicta D'Souza",
year = "2010",
month = "10",
day = "1",
language = "English",
volume = "21",
pages = "441--444",
journal = "Biomedical Research",
issn = "0970-938X",
publisher = "Scientific Publishers of India",
number = "4",

}

Erythrocyte malondialdeyde and antioxidant status in oral squamous cell carcinoma patients and tobacco chewers/smokers. / Raghavendra, U.; D'Souza, Vivian; D'Souza, Benedicta.

In: Biomedical Research, Vol. 21, No. 4, 01.10.2010, p. 441-444.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Erythrocyte malondialdeyde and antioxidant status in oral squamous cell carcinoma patients and tobacco chewers/smokers

AU - Raghavendra, U.

AU - D'Souza, Vivian

AU - D'Souza, Benedicta

PY - 2010/10/1

Y1 - 2010/10/1

N2 - The aim of this study was to evaluate the levels of lipid peroxidation and antioxidants in the erythrocytes of oral cancer patients and tobacco chewers/smokers. 25 patients with biopsy proven oral squamous cell carcinoma(OSCC), 25 cases of tobacco chewers/smokers and 25 age and sex matched healthy control subjects were included in the study. The levels of malondialdehyde (MDA), a lipid peroxidation marker and antioxidants like superoxide dismutase(SOD) and glutathione(G-SH) were determined by colorimetric methods. Erythrocyte MDA levels were significantly increased (P<0.001) and erythrocyte SOD and G-SH levels were significantly reduced (P<0.001) in OSCC patients compared to control subjects, where as statistically significant increase(P<0.05) in SOD was observed in tobacco chewers/smokers group. There is a negative correlation between MDA and G-SH in OSCC patients and tobacco chewers/smokers. This study shows that there is higher magnitude of oxidative stress in OSCC patients and a weak antioxidant defense system makes the mucosal cells more vulnerable to the genotoxic effect of reactive oxygen species(ROS). A diet rich in antioxidants may alleviate the oxidative stress to some extent.

AB - The aim of this study was to evaluate the levels of lipid peroxidation and antioxidants in the erythrocytes of oral cancer patients and tobacco chewers/smokers. 25 patients with biopsy proven oral squamous cell carcinoma(OSCC), 25 cases of tobacco chewers/smokers and 25 age and sex matched healthy control subjects were included in the study. The levels of malondialdehyde (MDA), a lipid peroxidation marker and antioxidants like superoxide dismutase(SOD) and glutathione(G-SH) were determined by colorimetric methods. Erythrocyte MDA levels were significantly increased (P<0.001) and erythrocyte SOD and G-SH levels were significantly reduced (P<0.001) in OSCC patients compared to control subjects, where as statistically significant increase(P<0.05) in SOD was observed in tobacco chewers/smokers group. There is a negative correlation between MDA and G-SH in OSCC patients and tobacco chewers/smokers. This study shows that there is higher magnitude of oxidative stress in OSCC patients and a weak antioxidant defense system makes the mucosal cells more vulnerable to the genotoxic effect of reactive oxygen species(ROS). A diet rich in antioxidants may alleviate the oxidative stress to some extent.

UR - http://www.scopus.com/inward/record.url?scp=80051515387&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051515387&partnerID=8YFLogxK

M3 - Article

VL - 21

SP - 441

EP - 444

JO - Biomedical Research

JF - Biomedical Research

SN - 0970-938X

IS - 4

ER -