Erythrocyte malondialdeyde and antioxidant status in oral squamous cell carcinoma patients and tobacco chewers/smokers

U. Raghavendra, Vivian D'Souza, Benedicta D'Souza

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The aim of this study was to evaluate the levels of lipid peroxidation and antioxidants in the erythrocytes of oral cancer patients and tobacco chewers/smokers. 25 patients with biopsy proven oral squamous cell carcinoma(OSCC), 25 cases of tobacco chewers/smokers and 25 age and sex matched healthy control subjects were included in the study. The levels of malondialdehyde (MDA), a lipid peroxidation marker and antioxidants like superoxide dismutase(SOD) and glutathione(G-SH) were determined by colorimetric methods. Erythrocyte MDA levels were significantly increased (P<0.001) and erythrocyte SOD and G-SH levels were significantly reduced (P<0.001) in OSCC patients compared to control subjects, where as statistically significant increase(P<0.05) in SOD was observed in tobacco chewers/smokers group. There is a negative correlation between MDA and G-SH in OSCC patients and tobacco chewers/smokers. This study shows that there is higher magnitude of oxidative stress in OSCC patients and a weak antioxidant defense system makes the mucosal cells more vulnerable to the genotoxic effect of reactive oxygen species(ROS). A diet rich in antioxidants may alleviate the oxidative stress to some extent.

Original languageEnglish
Pages (from-to)441-444
Number of pages4
JournalBiomedical Research
Volume21
Issue number4
Publication statusPublished - 01-10-2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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