Essential tremor

Beyond the motor features

Vijay Chandran, Pramod Kumar Pal

Research output: Contribution to journalReview article

61 Citations (Scopus)

Abstract

There is a growing evidence to suggest that apart from motor features, patients with Essential Tremor (ET) may have significant non-motor features. This review critically analyzes the available evidence of the various non-motor symptoms in patients with ET. Apart from tremor, patients with ET have been reported to have: (i) cognitive abnormalities characterized by mild frontal dysfunction that may have a functional impact, (ii) an association with dementia (both prevalent and incident) among those with late onset of tremor (>65 years), (iii) a higher prevalence of anxiety and an anxious and worrisome personality type, (iv) depressive symptomatology and may even have depression as a premotor symptom, (v) poor sleep quality and (vi) subjective hearing impairment. It is controversial whether olfactory dysfunction occurs in ET and its utility as a diagnostic aid. The biological basis for each of these observations requires further clarification and some findings need confirmation in population-based studies. However the available evidence is sufficient to support the notion that ET can no longer be considered as a pure motor disorder and further studies of these non-motor aspects will go a long way in understanding and comprehensively treating ET.

Original languageEnglish
Pages (from-to)407-413
Number of pages7
JournalParkinsonism and Related Disorders
Volume18
Issue number5
DOIs
Publication statusPublished - 01-06-2012
Externally publishedYes

Fingerprint

Essential Tremor
Tremor
Hearing Loss
Personality
Dementia
Sleep
Anxiety
Depression
Population

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology

Cite this

Chandran, Vijay ; Pal, Pramod Kumar. / Essential tremor : Beyond the motor features. In: Parkinsonism and Related Disorders. 2012 ; Vol. 18, No. 5. pp. 407-413.
@article{7640f577d8b44d03b69e47a3b91a0f10,
title = "Essential tremor: Beyond the motor features",
abstract = "There is a growing evidence to suggest that apart from motor features, patients with Essential Tremor (ET) may have significant non-motor features. This review critically analyzes the available evidence of the various non-motor symptoms in patients with ET. Apart from tremor, patients with ET have been reported to have: (i) cognitive abnormalities characterized by mild frontal dysfunction that may have a functional impact, (ii) an association with dementia (both prevalent and incident) among those with late onset of tremor (>65 years), (iii) a higher prevalence of anxiety and an anxious and worrisome personality type, (iv) depressive symptomatology and may even have depression as a premotor symptom, (v) poor sleep quality and (vi) subjective hearing impairment. It is controversial whether olfactory dysfunction occurs in ET and its utility as a diagnostic aid. The biological basis for each of these observations requires further clarification and some findings need confirmation in population-based studies. However the available evidence is sufficient to support the notion that ET can no longer be considered as a pure motor disorder and further studies of these non-motor aspects will go a long way in understanding and comprehensively treating ET.",
author = "Vijay Chandran and Pal, {Pramod Kumar}",
year = "2012",
month = "6",
day = "1",
doi = "10.1016/j.parkreldis.2011.12.003",
language = "English",
volume = "18",
pages = "407--413",
journal = "Parkinsonism and Related Disorders",
issn = "1353-8020",
publisher = "Elsevier BV",
number = "5",

}

Essential tremor : Beyond the motor features. / Chandran, Vijay; Pal, Pramod Kumar.

In: Parkinsonism and Related Disorders, Vol. 18, No. 5, 01.06.2012, p. 407-413.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Essential tremor

T2 - Beyond the motor features

AU - Chandran, Vijay

AU - Pal, Pramod Kumar

PY - 2012/6/1

Y1 - 2012/6/1

N2 - There is a growing evidence to suggest that apart from motor features, patients with Essential Tremor (ET) may have significant non-motor features. This review critically analyzes the available evidence of the various non-motor symptoms in patients with ET. Apart from tremor, patients with ET have been reported to have: (i) cognitive abnormalities characterized by mild frontal dysfunction that may have a functional impact, (ii) an association with dementia (both prevalent and incident) among those with late onset of tremor (>65 years), (iii) a higher prevalence of anxiety and an anxious and worrisome personality type, (iv) depressive symptomatology and may even have depression as a premotor symptom, (v) poor sleep quality and (vi) subjective hearing impairment. It is controversial whether olfactory dysfunction occurs in ET and its utility as a diagnostic aid. The biological basis for each of these observations requires further clarification and some findings need confirmation in population-based studies. However the available evidence is sufficient to support the notion that ET can no longer be considered as a pure motor disorder and further studies of these non-motor aspects will go a long way in understanding and comprehensively treating ET.

AB - There is a growing evidence to suggest that apart from motor features, patients with Essential Tremor (ET) may have significant non-motor features. This review critically analyzes the available evidence of the various non-motor symptoms in patients with ET. Apart from tremor, patients with ET have been reported to have: (i) cognitive abnormalities characterized by mild frontal dysfunction that may have a functional impact, (ii) an association with dementia (both prevalent and incident) among those with late onset of tremor (>65 years), (iii) a higher prevalence of anxiety and an anxious and worrisome personality type, (iv) depressive symptomatology and may even have depression as a premotor symptom, (v) poor sleep quality and (vi) subjective hearing impairment. It is controversial whether olfactory dysfunction occurs in ET and its utility as a diagnostic aid. The biological basis for each of these observations requires further clarification and some findings need confirmation in population-based studies. However the available evidence is sufficient to support the notion that ET can no longer be considered as a pure motor disorder and further studies of these non-motor aspects will go a long way in understanding and comprehensively treating ET.

UR - http://www.scopus.com/inward/record.url?scp=84861189888&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861189888&partnerID=8YFLogxK

U2 - 10.1016/j.parkreldis.2011.12.003

DO - 10.1016/j.parkreldis.2011.12.003

M3 - Review article

VL - 18

SP - 407

EP - 413

JO - Parkinsonism and Related Disorders

JF - Parkinsonism and Related Disorders

SN - 1353-8020

IS - 5

ER -