Establishing the Evidence Bar for Molecular Diagnostics in Personalised Cancer Care

Daniel Schneider, Giampaolo Bianchini, Denis Horgan, Stefan Michiels, Wim Witjes, Robert Hills, Juliette Plun-Favreau, Angela Brand, Mark Lawler

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

While personalised cancer medicine holds great promise, targeting therapies to the biological characteristics of patients is limited by the number of validated biomarkers currently available. The implementation of biomarkers has undergone many challenges with few biomarkers reaching cancer patients in the clinic. There have been many biomarkers that have been published and claimed to be therapeutically useful, but few become part of the clinical decision-making process due to technical, validation and market access issues. To reduce this attrition rate, there is a significant need for policy makers and reimbursement agencies to define specific evidence requirements for the introduction of biomarkers into clinical practice. Once these requirements are more clearly defined, in an analogous manner to pharmaceuticals, researchers and diagnostic companies can better focus their biomarker research and development on meeting these specific requirements, which should lead to the more rapid introduction of new molecular oncology tests for patient benefit.

Original languageEnglish
Pages (from-to)349-358
Number of pages10
JournalPublic Health Genomics
Volume18
Issue number6
DOIs
Publication statusPublished - 01-12-2015

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Genetics(clinical)

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    Schneider, D., Bianchini, G., Horgan, D., Michiels, S., Witjes, W., Hills, R., Plun-Favreau, J., Brand, A., & Lawler, M. (2015). Establishing the Evidence Bar for Molecular Diagnostics in Personalised Cancer Care. Public Health Genomics, 18(6), 349-358. https://doi.org/10.1159/000441556