Establishment and characterization of induced pluripotent stem cells from placental mesenchymal stromal cells

Shagufta Parveen

Research output: Contribution to journalArticle

Abstract

Human term placenta is a bulky organ which harbours abundant mesenchymal stromal cells. This study reports isolation and characterization of placental mesenchymal stromal cells (PMSCs) followed by reprogramming of PMSCs to induced pluripotent stem cells (iPSCs). The placental human iPSC (PhiPSC) line is pluripotent with high telomerase activity, genetically identical to parental PMSCs, transgene free, karyotypically normal and differentiates into ectoderm, mesoderm and endoderm both in vitro and in vivo. Thus PMSCs serve as a unique cell type for human perinatal iPSC derivation from extra embryonic tissue.

Original languageEnglish
Pages (from-to)15-20
Number of pages6
JournalStem Cell Research
Volume27
DOIs
Publication statusPublished - 01-03-2018

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Induced Pluripotent Stem Cells
Mesenchymal Stromal Cells
Endoderm
Ectoderm
Telomerase
Mesoderm
Transgenes
Placenta
Cell Line

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

Cite this

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Establishment and characterization of induced pluripotent stem cells from placental mesenchymal stromal cells. / Parveen, Shagufta.

In: Stem Cell Research, Vol. 27, 01.03.2018, p. 15-20.

Research output: Contribution to journalArticle

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