Estimation of L-fucose and sialic acid as prognostic markers in precancerous condition in Mangalore population

Roopesh J. Poojary, Suchetha Kumari, A. K. Nayanatara, Rashmi Kaup Shiva, N. A. Vinodini, Dharnappa Poojary

Research output: Contribution to journalArticle

Abstract

Oral pre cancer is a lesion found in the oral cavity and oropharynx. Sialic acid (N-acetyl neuraminic acid) and L-fucose (6 deoxy-L galactose) are the monosacharides present in the mammalian cells. Literature review has showed a clear link between these monosaccharides and various carcinomas. Objectives of the present study is to estimate and compare the status of Sialic acid and L-fucose in precancerous patients. Present study is conducted in compliance with the ethical committee guidelines of the institute. Sixty subjects with the age range 20-60 years were included in the current study. The study group included clinically diagnosed cases of oral sub mucous fibrosis, leukoplakia and erythroplakia. These were clinically confirmed cases of oral pre-cancer. L-fucose and sialic acid were measured by Winzlers method in serum sample. The levels of Sialic acid and L-fucose were found to be increased significantly increased in various stages of pre cancer in comparison with the normal subjects (p > 0.001). When pre-cancer develops, cell to cell adhesiveness is diminished among these cells and they easily enter into the blood stream. The level of serum Sialic acid and L-Fucose increases along with the severity and inflammation of the tissues.

Original languageEnglish
Pages (from-to)2709-2712
Number of pages4
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume7
Issue number3
Publication statusPublished - 01-01-2016

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All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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