Estimation of the solubility parameter of trimethoprim by current methods

C.V.S. Subrahmanyam, K.R. Prakash, P.G. Rao

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Group contribution, the extended Hildebrand solubility (EHS) and the extended Hansen solubility approaches are utilised to estimate the solubility parameter value of trimethoprim. The solubility data in the binary solvent series showed peak solubility at the solubility parameter of solvent, 11.7 H. The regression expression on the lines of the EHS approach yielded 12.06 H. The data on the solubility of trimethoprim in individual solvents was processed as per the extended Hansen approach. The partial solubility parameters were obtained and are used to estimate the solubility parameter, 12.93 H. Extending the Flory-Huggins size correction to this approach gave a value of 10.95 H and improved the correlation coefficient by 3 percent. Partitioning of hydrogen bonding (four parameter approach) didn't improve the value.
Original languageUndefined/Unknown
Pages (from-to)175-183
Number of pages9
JournalPharmaceutica Acta Helvetiae
Volume71
Issue number3
DOIs
Publication statusPublished - 1996

Cite this

Subrahmanyam, C.V.S. ; Prakash, K.R. ; Rao, P.G. / Estimation of the solubility parameter of trimethoprim by current methods. In: Pharmaceutica Acta Helvetiae. 1996 ; Vol. 71, No. 3. pp. 175-183.
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Estimation of the solubility parameter of trimethoprim by current methods. / Subrahmanyam, C.V.S.; Prakash, K.R.; Rao, P.G.

In: Pharmaceutica Acta Helvetiae, Vol. 71, No. 3, 1996, p. 175-183.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Estimation of the solubility parameter of trimethoprim by current methods

AU - Subrahmanyam, C.V.S.

AU - Prakash, K.R.

AU - Rao, P.G.

N1 - cited By 20

PY - 1996

Y1 - 1996

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AB - Group contribution, the extended Hildebrand solubility (EHS) and the extended Hansen solubility approaches are utilised to estimate the solubility parameter value of trimethoprim. The solubility data in the binary solvent series showed peak solubility at the solubility parameter of solvent, 11.7 H. The regression expression on the lines of the EHS approach yielded 12.06 H. The data on the solubility of trimethoprim in individual solvents was processed as per the extended Hansen approach. The partial solubility parameters were obtained and are used to estimate the solubility parameter, 12.93 H. Extending the Flory-Huggins size correction to this approach gave a value of 10.95 H and improved the correlation coefficient by 3 percent. Partitioning of hydrogen bonding (four parameter approach) didn't improve the value.

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