Evaluation of anti-inflammatory activity of Alcoholic extract of leaves of Leucas Aspera in albino rats

Navin Patil, H. S. Somashekar, Suneel Kumar Reddy, Vinod Nayak, S. Narendranath, K. L. Bairy, Amrita Parida, Chaithanya Malalur, Rahul P. Kotian

Research output: Contribution to journalArticle

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Abstract

Objective: Alcoholic extract of leaves of Leucas Aspera was tested for anti-inflammatory activity in animal models. Methods: Three doses, 100 mg/kg, 200 mg/kg and 400 mg/kg of the plant extract prepared as a suspension in 1% tween 80 in normal saline.The control group received only Tween 80 (2%, v/v) orally. Acute and sub-acute inflammatory activities were studied in rats by carrageenan induced paw edema and cotton pellet induced granuloma models respectively. In both models, the standard drug used was diclofenac 150 mg/kg. Results: All the three test doses (100mg/kg, 200mg/kg,400mg/kg) at different time intervals(0-4 hours) did exhibit anti-inflammatory activity in both models ie.Carrageenan model and cotton pellet granuloma model in comparison to control. The test dose of 400mg/kg of leucas aspera produced a percentage inhibition of 60.64%which was comparable to standard drug Diclofenac which produced a percentage inhibition of 60.70% in carrageenan model, whilst the percentage inhibition by cotton pellet method for standard drug was 60.27% and for three different doses of test (100,200,400mg/kg) was 50.85%,57.63%, and 58.42% respectively. Conclusion: Leucas Aspera possesses significant anti-inflammatory activity with p value (0.0001).

Original languageEnglish
Pages (from-to)715-719
Number of pages5
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume6
Issue numberSUPPL. 2
Publication statusPublished - 01-01-2014

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Carrageenan
Anti-Inflammatory Agents
Polysorbates
Diclofenac
Granuloma
Pharmaceutical Preparations
Plant Extracts
Edema
Suspensions
Animal Models
Control Groups

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Patil, Navin ; Somashekar, H. S. ; Reddy, Suneel Kumar ; Nayak, Vinod ; Narendranath, S. ; Bairy, K. L. ; Parida, Amrita ; Malalur, Chaithanya ; Kotian, Rahul P. / Evaluation of anti-inflammatory activity of Alcoholic extract of leaves of Leucas Aspera in albino rats. In: International Journal of Pharmacy and Pharmaceutical Sciences. 2014 ; Vol. 6, No. SUPPL. 2. pp. 715-719.
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abstract = "Objective: Alcoholic extract of leaves of Leucas Aspera was tested for anti-inflammatory activity in animal models. Methods: Three doses, 100 mg/kg, 200 mg/kg and 400 mg/kg of the plant extract prepared as a suspension in 1{\%} tween 80 in normal saline.The control group received only Tween 80 (2{\%}, v/v) orally. Acute and sub-acute inflammatory activities were studied in rats by carrageenan induced paw edema and cotton pellet induced granuloma models respectively. In both models, the standard drug used was diclofenac 150 mg/kg. Results: All the three test doses (100mg/kg, 200mg/kg,400mg/kg) at different time intervals(0-4 hours) did exhibit anti-inflammatory activity in both models ie.Carrageenan model and cotton pellet granuloma model in comparison to control. The test dose of 400mg/kg of leucas aspera produced a percentage inhibition of 60.64{\%}which was comparable to standard drug Diclofenac which produced a percentage inhibition of 60.70{\%} in carrageenan model, whilst the percentage inhibition by cotton pellet method for standard drug was 60.27{\%} and for three different doses of test (100,200,400mg/kg) was 50.85{\%},57.63{\%}, and 58.42{\%} respectively. Conclusion: Leucas Aspera possesses significant anti-inflammatory activity with p value (0.0001).",
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Evaluation of anti-inflammatory activity of Alcoholic extract of leaves of Leucas Aspera in albino rats. / Patil, Navin; Somashekar, H. S.; Reddy, Suneel Kumar; Nayak, Vinod; Narendranath, S.; Bairy, K. L.; Parida, Amrita; Malalur, Chaithanya; Kotian, Rahul P.

In: International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, No. SUPPL. 2, 01.01.2014, p. 715-719.

Research output: Contribution to journalArticle

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T1 - Evaluation of anti-inflammatory activity of Alcoholic extract of leaves of Leucas Aspera in albino rats

AU - Patil, Navin

AU - Somashekar, H. S.

AU - Reddy, Suneel Kumar

AU - Nayak, Vinod

AU - Narendranath, S.

AU - Bairy, K. L.

AU - Parida, Amrita

AU - Malalur, Chaithanya

AU - Kotian, Rahul P.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective: Alcoholic extract of leaves of Leucas Aspera was tested for anti-inflammatory activity in animal models. Methods: Three doses, 100 mg/kg, 200 mg/kg and 400 mg/kg of the plant extract prepared as a suspension in 1% tween 80 in normal saline.The control group received only Tween 80 (2%, v/v) orally. Acute and sub-acute inflammatory activities were studied in rats by carrageenan induced paw edema and cotton pellet induced granuloma models respectively. In both models, the standard drug used was diclofenac 150 mg/kg. Results: All the three test doses (100mg/kg, 200mg/kg,400mg/kg) at different time intervals(0-4 hours) did exhibit anti-inflammatory activity in both models ie.Carrageenan model and cotton pellet granuloma model in comparison to control. The test dose of 400mg/kg of leucas aspera produced a percentage inhibition of 60.64%which was comparable to standard drug Diclofenac which produced a percentage inhibition of 60.70% in carrageenan model, whilst the percentage inhibition by cotton pellet method for standard drug was 60.27% and for three different doses of test (100,200,400mg/kg) was 50.85%,57.63%, and 58.42% respectively. Conclusion: Leucas Aspera possesses significant anti-inflammatory activity with p value (0.0001).

AB - Objective: Alcoholic extract of leaves of Leucas Aspera was tested for anti-inflammatory activity in animal models. Methods: Three doses, 100 mg/kg, 200 mg/kg and 400 mg/kg of the plant extract prepared as a suspension in 1% tween 80 in normal saline.The control group received only Tween 80 (2%, v/v) orally. Acute and sub-acute inflammatory activities were studied in rats by carrageenan induced paw edema and cotton pellet induced granuloma models respectively. In both models, the standard drug used was diclofenac 150 mg/kg. Results: All the three test doses (100mg/kg, 200mg/kg,400mg/kg) at different time intervals(0-4 hours) did exhibit anti-inflammatory activity in both models ie.Carrageenan model and cotton pellet granuloma model in comparison to control. The test dose of 400mg/kg of leucas aspera produced a percentage inhibition of 60.64%which was comparable to standard drug Diclofenac which produced a percentage inhibition of 60.70% in carrageenan model, whilst the percentage inhibition by cotton pellet method for standard drug was 60.27% and for three different doses of test (100,200,400mg/kg) was 50.85%,57.63%, and 58.42% respectively. Conclusion: Leucas Aspera possesses significant anti-inflammatory activity with p value (0.0001).

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SN - 0975-1491

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