Evaluation of anti-tumor efficacy of injectable Centchroman in mice bearing Ehrlich ascites carcinoma

B. Dinesh Shenoy, N. Udupa, R. Kamath, P. Uma Devi

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Abstract

Anti-tumor efficacy of Centchroman formulated as niosomes and gel implant was evaluated in Swiss albino mice bearing Ehrlich ascites carcinoma at 10 mg/kg body weight dose given subcutaneously. Median day of death, percentage increase in host life span and changes in body weight were studied. Centchroman significantly (p<0.05) increased the median day of death both in free and formulated systems. Also, injectable formulations exhibited a significant (p<0.05) increase in host life span compared to free drug, hence, enhanced anti-tumor efficacy against Ehrlich ascites carcinoma.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalIndian Journal of Physiology and Pharmacology
Volume43
Issue number2
Publication statusPublished - 04-1999

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All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology

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