Evaluation of anti-tumor efficacy of injectable Centchroman in mice bearing Ehrlich ascites carcinoma

B. Dinesh Shenoy, N. Udupa, R. Kamath, P. Uma Devi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Anti-tumor efficacy of Centchroman formulated as niosomes and gel implant was evaluated in Swiss albino mice bearing Ehrlich ascites carcinoma at 10 mg/kg body weight dose given subcutaneously. Median day of death, percentage increase in host life span and changes in body weight were studied. Centchroman significantly (p<0.05) increased the median day of death both in free and formulated systems. Also, injectable formulations exhibited a significant (p<0.05) increase in host life span compared to free drug, hence, enhanced anti-tumor efficacy against Ehrlich ascites carcinoma.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalIndian Journal of Physiology and Pharmacology
Volume43
Issue number2
Publication statusPublished - 04-1999

Fingerprint

Centchroman
Ascites
Carcinoma
Body Weight Changes
Injections
Liposomes
Neoplasms
Gels
Body Weight
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology

Cite this

@article{3af260c3d8214573b07acf991791e6ba,
title = "Evaluation of anti-tumor efficacy of injectable Centchroman in mice bearing Ehrlich ascites carcinoma",
abstract = "Anti-tumor efficacy of Centchroman formulated as niosomes and gel implant was evaluated in Swiss albino mice bearing Ehrlich ascites carcinoma at 10 mg/kg body weight dose given subcutaneously. Median day of death, percentage increase in host life span and changes in body weight were studied. Centchroman significantly (p<0.05) increased the median day of death both in free and formulated systems. Also, injectable formulations exhibited a significant (p<0.05) increase in host life span compared to free drug, hence, enhanced anti-tumor efficacy against Ehrlich ascites carcinoma.",
author = "Shenoy, {B. Dinesh} and N. Udupa and R. Kamath and Devi, {P. Uma}",
year = "1999",
month = "4",
language = "English",
volume = "43",
pages = "259--262",
journal = "Indian Journal of Physiology and Pharmacology",
issn = "0019-5499",
publisher = "Association of Physiologists and Pharmacologists of India",
number = "2",

}

Evaluation of anti-tumor efficacy of injectable Centchroman in mice bearing Ehrlich ascites carcinoma. / Shenoy, B. Dinesh; Udupa, N.; Kamath, R.; Devi, P. Uma.

In: Indian Journal of Physiology and Pharmacology, Vol. 43, No. 2, 04.1999, p. 259-262.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of anti-tumor efficacy of injectable Centchroman in mice bearing Ehrlich ascites carcinoma

AU - Shenoy, B. Dinesh

AU - Udupa, N.

AU - Kamath, R.

AU - Devi, P. Uma

PY - 1999/4

Y1 - 1999/4

N2 - Anti-tumor efficacy of Centchroman formulated as niosomes and gel implant was evaluated in Swiss albino mice bearing Ehrlich ascites carcinoma at 10 mg/kg body weight dose given subcutaneously. Median day of death, percentage increase in host life span and changes in body weight were studied. Centchroman significantly (p<0.05) increased the median day of death both in free and formulated systems. Also, injectable formulations exhibited a significant (p<0.05) increase in host life span compared to free drug, hence, enhanced anti-tumor efficacy against Ehrlich ascites carcinoma.

AB - Anti-tumor efficacy of Centchroman formulated as niosomes and gel implant was evaluated in Swiss albino mice bearing Ehrlich ascites carcinoma at 10 mg/kg body weight dose given subcutaneously. Median day of death, percentage increase in host life span and changes in body weight were studied. Centchroman significantly (p<0.05) increased the median day of death both in free and formulated systems. Also, injectable formulations exhibited a significant (p<0.05) increase in host life span compared to free drug, hence, enhanced anti-tumor efficacy against Ehrlich ascites carcinoma.

UR - http://www.scopus.com/inward/record.url?scp=0033008213&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033008213&partnerID=8YFLogxK

M3 - Article

VL - 43

SP - 259

EP - 262

JO - Indian Journal of Physiology and Pharmacology

JF - Indian Journal of Physiology and Pharmacology

SN - 0019-5499

IS - 2

ER -