Evaluation of anticonvulsant activity of magnesium oxide alone and along with carbamazepine

Navin A. Patil, H. S. Somashekar, S. Narendranath, Prashanth, Suneel Kumar Reddy, Anoosha Bhandarkar

Research output: Contribution to journalArticle

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Abstract

Objectives: To evaluate the anticonvulsant effect of magnesium oxide alone and its activity alongside carbamazepine in albino rats. Materials and methods: In MES (maximal electric shock) method, 36 male albino rats weighing between 100-200gm, were divided into 6 groups each containing 6 animals were all treated with magnesium oxide (500,1000mg/kg) for 10 days orally. On 11th day Carbamazepine (50,30mg/Kg) was given orally an hour before MES induced seizures except control and only magnesium oxide groups. Abolition of tonic hind limb extention reflex and time taken to regain righting reflex were noted for each animal after MES induced seizures. Results: Low dose oral administration (500mg/kg) for 10 days in healthy rat showed 33.33% protection to MES, while the group with high dose magnesium (1000mg/kg) showed no protection to MES. Low oral dose of magnesium (500mg/kg) along with low dose carbamazepine (30mg/kg) showed better results than groups with only carbamazepine and high dose carbamazepine (50mg/kg) along with low dose magnesium oxide(500mg/kg). Conclusion: Low dose magnesium has anticonvulsant activity in MES seizure model, moreover combination of low dose magnesium oxide with low dose carbamazepine showed better results considering both the end points(THLE and TRR) in MES induced seizure model.

Original languageEnglish
Pages (from-to)142-145
Number of pages4
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume5
Issue number2
Publication statusPublished - 01-04-2012

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Magnesium Oxide
Carbamazepine
Anticonvulsants
Shock
Seizures
Magnesium
Righting Reflex
Oral Administration
Reflex
Extremities

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Pharmacology
  • Pharmacology (medical)

Cite this

Patil, N. A., Somashekar, H. S., Narendranath, S., Prashanth, Reddy, S. K., & Bhandarkar, A. (2012). Evaluation of anticonvulsant activity of magnesium oxide alone and along with carbamazepine. Asian Journal of Pharmaceutical and Clinical Research, 5(2), 142-145.
Patil, Navin A. ; Somashekar, H. S. ; Narendranath, S. ; Prashanth ; Reddy, Suneel Kumar ; Bhandarkar, Anoosha. / Evaluation of anticonvulsant activity of magnesium oxide alone and along with carbamazepine. In: Asian Journal of Pharmaceutical and Clinical Research. 2012 ; Vol. 5, No. 2. pp. 142-145.
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Patil, NA, Somashekar, HS, Narendranath, S, Prashanth, Reddy, SK & Bhandarkar, A 2012, 'Evaluation of anticonvulsant activity of magnesium oxide alone and along with carbamazepine', Asian Journal of Pharmaceutical and Clinical Research, vol. 5, no. 2, pp. 142-145.

Evaluation of anticonvulsant activity of magnesium oxide alone and along with carbamazepine. / Patil, Navin A.; Somashekar, H. S.; Narendranath, S.; Prashanth; Reddy, Suneel Kumar; Bhandarkar, Anoosha.

In: Asian Journal of Pharmaceutical and Clinical Research, Vol. 5, No. 2, 01.04.2012, p. 142-145.

Research output: Contribution to journalArticle

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N2 - Objectives: To evaluate the anticonvulsant effect of magnesium oxide alone and its activity alongside carbamazepine in albino rats. Materials and methods: In MES (maximal electric shock) method, 36 male albino rats weighing between 100-200gm, were divided into 6 groups each containing 6 animals were all treated with magnesium oxide (500,1000mg/kg) for 10 days orally. On 11th day Carbamazepine (50,30mg/Kg) was given orally an hour before MES induced seizures except control and only magnesium oxide groups. Abolition of tonic hind limb extention reflex and time taken to regain righting reflex were noted for each animal after MES induced seizures. Results: Low dose oral administration (500mg/kg) for 10 days in healthy rat showed 33.33% protection to MES, while the group with high dose magnesium (1000mg/kg) showed no protection to MES. Low oral dose of magnesium (500mg/kg) along with low dose carbamazepine (30mg/kg) showed better results than groups with only carbamazepine and high dose carbamazepine (50mg/kg) along with low dose magnesium oxide(500mg/kg). Conclusion: Low dose magnesium has anticonvulsant activity in MES seizure model, moreover combination of low dose magnesium oxide with low dose carbamazepine showed better results considering both the end points(THLE and TRR) in MES induced seizure model.

AB - Objectives: To evaluate the anticonvulsant effect of magnesium oxide alone and its activity alongside carbamazepine in albino rats. Materials and methods: In MES (maximal electric shock) method, 36 male albino rats weighing between 100-200gm, were divided into 6 groups each containing 6 animals were all treated with magnesium oxide (500,1000mg/kg) for 10 days orally. On 11th day Carbamazepine (50,30mg/Kg) was given orally an hour before MES induced seizures except control and only magnesium oxide groups. Abolition of tonic hind limb extention reflex and time taken to regain righting reflex were noted for each animal after MES induced seizures. Results: Low dose oral administration (500mg/kg) for 10 days in healthy rat showed 33.33% protection to MES, while the group with high dose magnesium (1000mg/kg) showed no protection to MES. Low oral dose of magnesium (500mg/kg) along with low dose carbamazepine (30mg/kg) showed better results than groups with only carbamazepine and high dose carbamazepine (50mg/kg) along with low dose magnesium oxide(500mg/kg). Conclusion: Low dose magnesium has anticonvulsant activity in MES seizure model, moreover combination of low dose magnesium oxide with low dose carbamazepine showed better results considering both the end points(THLE and TRR) in MES induced seizure model.

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