Evaluation of antinociceptive activity of Vanillin mediated through opioid receptors

U. P. Rathnakar, D. Srikanth, Vishma Hydie Menezes, K. Ashok Shenoy, Sahana D. Acharya, B. S. Nishchal, G. Shivaprakash, A. L. Udupa

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Abstract

Vanilla planifolia grown for its attractive aroma has rich medicinal value as evidenced by its antimutagenic, anti-invasive and anti-inflammatory activities. An analgesic activity mediated by opioid receptors has been suggested in earlier studies. Inbred adult wistar rats of either sex weighing 150-200grams were used for the study. Rats were randomly assigned to four groups [Control, morphine 2mg/kg, Vanillin 10mg/kg, Vanillin 100mg/kg] of six animals each. Eddy's hot plate method was used to evaluate analgesic activity. Naloxone pretreatment was employed to demonstrate any activity mediated through opioid receptors. There was significant increase (P<0.001) in latency period at 10mg/kg and 100 mg/kg doses of vanillin when compared to control. Naloxone pre-treatment significantly reduced the latency period in hot-plate test with both the doses of vanillin. Vanillin at a dose of 10 mg/kg and 100 mg/kg demonstrated a significant increase in latency period, displaying a potential central analgesic activity probably mediated through opioid receptors.

Original languageEnglish
Pages (from-to)674-676
Number of pages3
JournalDrug Invention Today
Volume4
Issue number12
Publication statusPublished - 01-12-2012

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All Science Journal Classification (ASJC) codes

  • Drug Discovery

Cite this

Rathnakar, U. P., Srikanth, D., Menezes, V. H., Ashok Shenoy, K., Acharya, S. D., Nishchal, B. S., ... Udupa, A. L. (2012). Evaluation of antinociceptive activity of Vanillin mediated through opioid receptors. Drug Invention Today, 4(12), 674-676.