Evaluation of antioxidant and antiparkinsonian activities of Brassica oleracea in haloperidol-induced tardive dyskinesia

S. Nagarjuna, M. Arifullah, A. Sanjeeva Kumar, B. Srinath, K. Somasekhar Reddy, Y. Padmanabha Reddy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Brassica oleracea is a leafy green vegetable commonly called as cabbage. It belongs to the family Brassicaceae. Studies reveal that it is rich in flavonoids and has high antioxidant property. Aims: The present study was aimed at evaluating antiparkinsonian activity of B. oleracea in haloperidol-induced tardive dyskinesia. Settings and Design: The present study was designed for 14 days administration of the plant extract then behavioral and biochemical parameters were estimated in the rats. Materials and Methods: B. oleracea was collected, dried in the shade, powdered, and subjected to the extraction by cold maceration using water and methanol mixture of H2O/CH3OH as a solvent. The extract was subjected to preliminary phytochemical screening. Haloperidol model was selected for screening antiparkinsonian activity, and it was administered at a dose of 1 mg/kg i.p., for 14 days. Behavioral and biochemical parameters were estimated in all the groups. Statistical Analysis Used: Statistical significance between more than two groups was tested using one-way ANOVA followed by the Bonferroni′s compare all columns test using the computer-based fitting program. Results: In groups treated with hydroalcoholic extract of B. oleracea (250 and 500 mg/kg p.o.,) decreased the elevated levels of lipid peroxidation in the haloperidol-treated animals and elevated the cellular defense mechanisms such as glutathione, further suggesting the role of free radicals in the pathophysiology of the haloperidol-induced extrapyramidal syndrome. Conclusion: This study reveals the use of B. oleracea in parkinsonian disease.

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalInternational Journal of Green Pharmacy
Volume9
Issue number3
DOIs
Publication statusPublished - 01-07-2015
Externally publishedYes

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Antiparkinson Agents
Brassica
Haloperidol
Antioxidants
Brassicaceae
Plant Extracts
Parkinsonian Disorders
Phytochemicals
Flavonoids
Vegetables
Lipid Peroxidation
Free Radicals
Glutathione
Methanol
Analysis of Variance
Tardive Dyskinesia
Water

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Nagarjuna, S. ; Arifullah, M. ; Kumar, A. Sanjeeva ; Srinath, B. ; Reddy, K. Somasekhar ; Reddy, Y. Padmanabha. / Evaluation of antioxidant and antiparkinsonian activities of Brassica oleracea in haloperidol-induced tardive dyskinesia. In: International Journal of Green Pharmacy. 2015 ; Vol. 9, No. 3. pp. 143-149.
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Evaluation of antioxidant and antiparkinsonian activities of Brassica oleracea in haloperidol-induced tardive dyskinesia. / Nagarjuna, S.; Arifullah, M.; Kumar, A. Sanjeeva; Srinath, B.; Reddy, K. Somasekhar; Reddy, Y. Padmanabha.

In: International Journal of Green Pharmacy, Vol. 9, No. 3, 01.07.2015, p. 143-149.

Research output: Contribution to journalArticle

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AU - Arifullah, M.

AU - Kumar, A. Sanjeeva

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