Evaluation of antioxidant potential of costus igneus in ethanol induced peroxidative damage in albino rats

G. Shivaprakash, Elizabeth Dilip Thottacherry, Seema Rai, Nischal, M. Nandini, Reshma Kumarachandra, Fahim, Natesh, L. C. Pallavi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Improved antioxidant status helps to minimize the oxidative damage and thus can delay the risk of developing many chronic age related, free radical induced damage in diseases like diabetes, cancer, neurodegenerative diseases. We tried to evaluate the antioxidant potential of Costus igneus (CI) leaves in ethanol induced peroxidative damage in albino rats. Wistar albino rats of either sex were divided into four groups. Group I was control group and received normal saline, Group II received ethanol, Group III received test drug CI at 300 mg/kg and Group IV received CI at dose of 600 mg/kg. Study duration was 30 days. Antioxidants estimated at the end of 30 days. The levels of reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) significantly reduced and (malondialdehyde) MDA levels raised in ethanol treated group compared to control group. The levels of reduced glutathione, SOD and catalase enzyme recovered completely in a dose dependent manner. Results demonstrate CI significantly reversed the reduction of GSH, SOD and CAT and reduced significantly the levels of MDA, a biomarker of lipid peroxidation in a dose dependent manner, suggesting its ability to enhance the antioxidant defense to prevent alcohol induced oxidative stress injury.

Original languageEnglish
Pages (from-to)52-55
Number of pages4
JournalJournal of Applied Pharmaceutical Science
Volume4
Issue number8
DOIs
Publication statusPublished - 01-01-2014

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Costus
Ethanol
Antioxidants
Catalase
Superoxide Dismutase
Glutathione
Control Groups
Malondialdehyde
Neurodegenerative Diseases
Lipid Peroxidation
Free Radicals
Wistar Rats
Oxidative Stress
Biomarkers
Alcohols
Wounds and Injuries
Enzymes
Pharmaceutical Preparations
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

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Evaluation of antioxidant potential of costus igneus in ethanol induced peroxidative damage in albino rats. / Shivaprakash, G.; Thottacherry, Elizabeth Dilip; Rai, Seema; Nischal, ; Nandini, M.; Kumarachandra, Reshma; Fahim; Natesh; Pallavi, L. C.

In: Journal of Applied Pharmaceutical Science, Vol. 4, No. 8, 01.01.2014, p. 52-55.

Research output: Contribution to journalArticle

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