Abstract

Various chemical agents have been evaluated over the years with respect to their antimicrobial effects in the oral cavity; however, all are associated with side effects that prohibit regular long-term use. Therefore, the effectiveness of neem (Azadirachta indica A. Juss) leaf extract against plaque formation was assessed in males between the age group of 20-30 years over a period of 6 weeks. Present study includes formulation of mucoadhesive dental gel containing Azadirachta indica leaf extract (25mg/g). A 6-week clinical study was conducted to evaluate the efficacy of neem extract dental gel with commercially available chlorhexidine gluconate (0.2% w/v) mouthwash as positive control. Microbial evaluation of Streptococcus mutans and Lactobacilli species was carried out to determine the total decrease in the salivary bacterial count over a period of treatment using a semi-quantitative four quadrant streaking method. The results of the study suggested that the dental gel containing neem extract has significantly (P<0.05) reduced the plaque index and bacterial count than that of the control group.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalJournal of Ethnopharmacology
Volume90
Issue number1
DOIs
Publication statusPublished - 2004

Fingerprint

Azadirachta
Tooth
Bacterial Load
Gels
Mouthwashes
Streptococcus mutans
Lactobacillus
Mouth
Age Groups
Control Groups
Clinical Studies
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

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title = "Evaluation of antiplaque activity of Azadirachta indica leaf extract gel - A 6-week clinical study",
abstract = "Various chemical agents have been evaluated over the years with respect to their antimicrobial effects in the oral cavity; however, all are associated with side effects that prohibit regular long-term use. Therefore, the effectiveness of neem (Azadirachta indica A. Juss) leaf extract against plaque formation was assessed in males between the age group of 20-30 years over a period of 6 weeks. Present study includes formulation of mucoadhesive dental gel containing Azadirachta indica leaf extract (25mg/g). A 6-week clinical study was conducted to evaluate the efficacy of neem extract dental gel with commercially available chlorhexidine gluconate (0.2{\%} w/v) mouthwash as positive control. Microbial evaluation of Streptococcus mutans and Lactobacilli species was carried out to determine the total decrease in the salivary bacterial count over a period of treatment using a semi-quantitative four quadrant streaking method. The results of the study suggested that the dental gel containing neem extract has significantly (P<0.05) reduced the plaque index and bacterial count than that of the control group.",
author = "Pai, {M. Raveendra} and Acharya, {Leelavathi D.} and N. Udupa",
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Evaluation of antiplaque activity of Azadirachta indica leaf extract gel - A 6-week clinical study. / Pai, M. Raveendra; Acharya, Leelavathi D.; Udupa, N.

In: Journal of Ethnopharmacology, Vol. 90, No. 1, 2004, p. 99-103.

Research output: Contribution to journalArticle

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