Evaluation of causative factors in amlodipine induced pedal edema

Kiran Shetty, K. Ranjan Shetty, Pragna Rao, G. Vivek, G. S. Naveenchandra, Abdul Razak, Deepak, Amruth Kiran

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To study the edema causing factors in hypertensive, amlodipine-induced pedal edema patients. Methods: The present was a prospective, observational study. A total of one hundred and twenty-four essential hypertensive patients, of either gender attending the outpatient department of cardiology and medicine, were recruited for this study. Out of the 124 patients, 62 were of the amlodipine-induced pedal edema [AIPE] group and other 62 patients were amlodipine-treated non-edema [ATNE] group. All the patients were receiving a dosage of amlodipine 5 mg/day. All recruited patients completed the study. The present study conducted at Kasturba Hospital, Manipal. Results: The vanillyl mandelic acid (VMA) (mean±SD) 7.08±2.3 mg/24 h and 4.9±1.7 mg/24 h in AIPE and ATNE groups respectively. Blood pressure (BP) and VMA was higher in AIPE group than the ATNE group (p<0.001). Pulse rate (PR), serum proteins, creatinine, sodium, osmolality, did not show any significant difference between the two study groups. Conclusion: In essential hypertensive patients with AIPE group presented with a higher VMA level than the ATNE group. The elevated catecholamine’s possibly the causative factor for AIPE.

Original languageEnglish
Pages (from-to)304-306
Number of pages3
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume8
Issue number11
DOIs
Publication statusPublished - 2016

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Amlodipine
Foot
Edema
Cardiology
Osmolar Concentration
Catecholamines
Observational Studies
Blood Proteins
Creatinine
Outpatients
Heart Rate
Sodium
Medicine
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Shetty, Kiran ; Ranjan Shetty, K. ; Rao, Pragna ; Vivek, G. ; Naveenchandra, G. S. ; Razak, Abdul ; Deepak ; Kiran, Amruth. / Evaluation of causative factors in amlodipine induced pedal edema. In: International Journal of Pharmacy and Pharmaceutical Sciences. 2016 ; Vol. 8, No. 11. pp. 304-306.
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Evaluation of causative factors in amlodipine induced pedal edema. / Shetty, Kiran; Ranjan Shetty, K.; Rao, Pragna; Vivek, G.; Naveenchandra, G. S.; Razak, Abdul; Deepak; Kiran, Amruth.

In: International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 8, No. 11, 2016, p. 304-306.

Research output: Contribution to journalArticle

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