Evaluation of centella asiatica leaf extract for wound healing in sterptozotocin induced diabetic rats

B. Somashekar Shetty, Sudhakar Pemmineti

Research output: Contribution to journalArticle


The plant Centella asiatica is used in traditional medicine to treat a variety of disorders. The objective of this study presented in this report was to evaluate the wound healing potential of ethanolic extract of the plant in streptozotocin-induced diabetic rats. The study was carried out by using Wistar albino rats by creating excision and dead space wounds. The measured wound area of the Centella asiatica treated group was reduced significantly when compared to diabetic control animals. Significant increase in the weight of the granulation tissue and the hydroxyproline content were observed. The histological study of the healing tissue obtained from the experimental diabetic animals showed the fast lay-down of collagen when compared to the normal and diabetic control group. The fasting blood glucose values of the diabetic experimental group animals were significantly reduced when compared to the diabetic control animals. We noticed the correlation between the wound contraction rate and the blood glucose values. The results of the present study clearly demonstrate that the ethanolic extract of Centella asiatica possesses a definite prohealing action in normal healing as well as in the diabetes induced wound healing.

Original languageEnglish
Pages (from-to)1082-1090
Number of pages9
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Issue number2
Publication statusPublished - 01-04-2013

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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