Evaluation of costus speciosus in experimental models of depression in Albino mice

Zahoor Ahmad Rather, M. Nateshprabhu, D. S. Sushma, Kb Rakesh, Sunil Pai, D. Ullal Sheetal

Research output: Contribution to journalArticle

Abstract

Introduction: Despite theavailability of numerous antidepressant drugs the therapy of depression is far from satisfactory. Two of the many reasons for this are the delay in onset of effect and the adverse effects associated with most of the antidepressants. Costus speciosus rhizome has shown adaptogenic activity. Objective: To evaluate the antidepressant activity of50% aqueous-ethanol extract of Costus speciosus (CS) leaves in experimental models of depression. Materials and Methods: Male albino mice were randomly assigned to five groups of six each. We studied three doses of the leaf extract (100, 200 and 400 mg/kg) on two models of depression - forced swim test and tail suspension test. Imipramine was used as the standard control. Both acute and chronic effects were studied. Drugs (test drug, standard control and vehicle) were administeredorally, one hour before the experiment in the acute study and daily for 14 days for the chronic study. Results: Imipramine showed significant antidepressant activity as demonstrated by a reduction in duration of immobility in both acute and chronic studies of forced swim test and tail suspension test. CS showed a dose dependent antidepressant activity. CS-100 demonstrated an antide-pressant effect only in the acute forced swim test. CS-200 demonstrated an antidepressant activity in both acute and chronic forced swim test but not in tail suspension test. CS-400 showed maximum antidepressant activity in both acute and chronic studies, which was comparable to that of the standard drug imipramine. Conclusion: CS showed dose dependent antidepressant activity with CS-400 mg/kg showing maximum effect.

Original languageEnglish
Pages (from-to)483-486
Number of pages4
JournalPharmacognosy Journal
Volume8
Issue number5
DOIs
Publication statusPublished - 01-01-2016

Fingerprint

Costus
Antidepressive Agents
Theoretical Models
Hindlimb Suspension
Imipramine
Rhizome
Drug and Narcotic Control
Pharmaceutical Preparations
Ethanol

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Rather, Zahoor Ahmad ; Nateshprabhu, M. ; Sushma, D. S. ; Rakesh, Kb ; Pai, Sunil ; Ullal Sheetal, D. / Evaluation of costus speciosus in experimental models of depression in Albino mice. In: Pharmacognosy Journal. 2016 ; Vol. 8, No. 5. pp. 483-486.
@article{1c146c85a9f8429585b4ebbc9b1ac298,
title = "Evaluation of costus speciosus in experimental models of depression in Albino mice",
abstract = "Introduction: Despite theavailability of numerous antidepressant drugs the therapy of depression is far from satisfactory. Two of the many reasons for this are the delay in onset of effect and the adverse effects associated with most of the antidepressants. Costus speciosus rhizome has shown adaptogenic activity. Objective: To evaluate the antidepressant activity of50{\%} aqueous-ethanol extract of Costus speciosus (CS) leaves in experimental models of depression. Materials and Methods: Male albino mice were randomly assigned to five groups of six each. We studied three doses of the leaf extract (100, 200 and 400 mg/kg) on two models of depression - forced swim test and tail suspension test. Imipramine was used as the standard control. Both acute and chronic effects were studied. Drugs (test drug, standard control and vehicle) were administeredorally, one hour before the experiment in the acute study and daily for 14 days for the chronic study. Results: Imipramine showed significant antidepressant activity as demonstrated by a reduction in duration of immobility in both acute and chronic studies of forced swim test and tail suspension test. CS showed a dose dependent antidepressant activity. CS-100 demonstrated an antide-pressant effect only in the acute forced swim test. CS-200 demonstrated an antidepressant activity in both acute and chronic forced swim test but not in tail suspension test. CS-400 showed maximum antidepressant activity in both acute and chronic studies, which was comparable to that of the standard drug imipramine. Conclusion: CS showed dose dependent antidepressant activity with CS-400 mg/kg showing maximum effect.",
author = "Rather, {Zahoor Ahmad} and M. Nateshprabhu and Sushma, {D. S.} and Kb Rakesh and Sunil Pai and {Ullal Sheetal}, D.",
year = "2016",
month = "1",
day = "1",
doi = "10.5530/pj.2016.5.12",
language = "English",
volume = "8",
pages = "483--486",
journal = "Pharmacognosy Journal",
issn = "0975-3575",
publisher = "Pharmacognosy Network Worldwide",
number = "5",

}

Evaluation of costus speciosus in experimental models of depression in Albino mice. / Rather, Zahoor Ahmad; Nateshprabhu, M.; Sushma, D. S.; Rakesh, Kb; Pai, Sunil; Ullal Sheetal, D.

In: Pharmacognosy Journal, Vol. 8, No. 5, 01.01.2016, p. 483-486.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of costus speciosus in experimental models of depression in Albino mice

AU - Rather, Zahoor Ahmad

AU - Nateshprabhu, M.

AU - Sushma, D. S.

AU - Rakesh, Kb

AU - Pai, Sunil

AU - Ullal Sheetal, D.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Introduction: Despite theavailability of numerous antidepressant drugs the therapy of depression is far from satisfactory. Two of the many reasons for this are the delay in onset of effect and the adverse effects associated with most of the antidepressants. Costus speciosus rhizome has shown adaptogenic activity. Objective: To evaluate the antidepressant activity of50% aqueous-ethanol extract of Costus speciosus (CS) leaves in experimental models of depression. Materials and Methods: Male albino mice were randomly assigned to five groups of six each. We studied three doses of the leaf extract (100, 200 and 400 mg/kg) on two models of depression - forced swim test and tail suspension test. Imipramine was used as the standard control. Both acute and chronic effects were studied. Drugs (test drug, standard control and vehicle) were administeredorally, one hour before the experiment in the acute study and daily for 14 days for the chronic study. Results: Imipramine showed significant antidepressant activity as demonstrated by a reduction in duration of immobility in both acute and chronic studies of forced swim test and tail suspension test. CS showed a dose dependent antidepressant activity. CS-100 demonstrated an antide-pressant effect only in the acute forced swim test. CS-200 demonstrated an antidepressant activity in both acute and chronic forced swim test but not in tail suspension test. CS-400 showed maximum antidepressant activity in both acute and chronic studies, which was comparable to that of the standard drug imipramine. Conclusion: CS showed dose dependent antidepressant activity with CS-400 mg/kg showing maximum effect.

AB - Introduction: Despite theavailability of numerous antidepressant drugs the therapy of depression is far from satisfactory. Two of the many reasons for this are the delay in onset of effect and the adverse effects associated with most of the antidepressants. Costus speciosus rhizome has shown adaptogenic activity. Objective: To evaluate the antidepressant activity of50% aqueous-ethanol extract of Costus speciosus (CS) leaves in experimental models of depression. Materials and Methods: Male albino mice were randomly assigned to five groups of six each. We studied three doses of the leaf extract (100, 200 and 400 mg/kg) on two models of depression - forced swim test and tail suspension test. Imipramine was used as the standard control. Both acute and chronic effects were studied. Drugs (test drug, standard control and vehicle) were administeredorally, one hour before the experiment in the acute study and daily for 14 days for the chronic study. Results: Imipramine showed significant antidepressant activity as demonstrated by a reduction in duration of immobility in both acute and chronic studies of forced swim test and tail suspension test. CS showed a dose dependent antidepressant activity. CS-100 demonstrated an antide-pressant effect only in the acute forced swim test. CS-200 demonstrated an antidepressant activity in both acute and chronic forced swim test but not in tail suspension test. CS-400 showed maximum antidepressant activity in both acute and chronic studies, which was comparable to that of the standard drug imipramine. Conclusion: CS showed dose dependent antidepressant activity with CS-400 mg/kg showing maximum effect.

UR - http://www.scopus.com/inward/record.url?scp=85048306583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048306583&partnerID=8YFLogxK

U2 - 10.5530/pj.2016.5.12

DO - 10.5530/pj.2016.5.12

M3 - Article

AN - SCOPUS:85048306583

VL - 8

SP - 483

EP - 486

JO - Pharmacognosy Journal

JF - Pharmacognosy Journal

SN - 0975-3575

IS - 5

ER -