Evaluation of covariates using population pharmacokinetics approach for dose individualization of levothyroxine in patients with post thyroidectomy and131i ablation therapy

Rajesh Kumar, Mukhyaprana Prabhu, Sreedhar R. Pai, Vasudev Shenoy

Research output: Contribution to journalArticle

Abstract

The current therapy for patients with thyroid cancer is total or near to total thyroidectomy with Radio Iodine treatment. Subsequent to the thyroidectomy the patients are on Levothyroxine as a supplement therapy to maintain the Thyroid hormone levels.Levothyroxine has been considered as a narrow therapeutic index drug. In Thyroid cancer patients, radio-iodine ablation procedure causes hypothyroid state which will be further elongated by the administration of sub optimal doses and hyperthyroid symptoms with higher doses. The current study was conducted to evaluate the covariates influencing the drug concentration of levothyroxine in our target population, i.e Patient with Papillary carcinoma, undergone total thyroidectomy followed by131I ablation and on Levothyroxine.

Original languageEnglish
Pages (from-to)2050-2054
Number of pages5
JournalResearch Journal of Pharmacy and Technology
Volume11
Issue number5
DOIs
Publication statusPublished - 01-05-2018

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Thyroidectomy
Thyroxine
Pharmacokinetics
Radio
Thyroid Neoplasms
Iodine
Population
Health Services Needs and Demand
Papillary Carcinoma
Hyperthyroidism
Therapeutics
Thyroid Hormones
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Pharmacology (medical)

Cite this

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abstract = "The current therapy for patients with thyroid cancer is total or near to total thyroidectomy with Radio Iodine treatment. Subsequent to the thyroidectomy the patients are on Levothyroxine as a supplement therapy to maintain the Thyroid hormone levels.Levothyroxine has been considered as a narrow therapeutic index drug. In Thyroid cancer patients, radio-iodine ablation procedure causes hypothyroid state which will be further elongated by the administration of sub optimal doses and hyperthyroid symptoms with higher doses. The current study was conducted to evaluate the covariates influencing the drug concentration of levothyroxine in our target population, i.e Patient with Papillary carcinoma, undergone total thyroidectomy followed by131I ablation and on Levothyroxine.",
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