Abstract
The current therapy for patients with thyroid cancer is total or near to total thyroidectomy with Radio Iodine treatment. Subsequent to the thyroidectomy the patients are on Levothyroxine as a supplement therapy to maintain the Thyroid hormone levels.Levothyroxine has been considered as a narrow therapeutic index drug. In Thyroid cancer patients, radio-iodine ablation procedure causes hypothyroid state which will be further elongated by the administration of sub optimal doses and hyperthyroid symptoms with higher doses. The current study was conducted to evaluate the covariates influencing the drug concentration of levothyroxine in our target population, i.e Patient with Papillary carcinoma, undergone total thyroidectomy followed by131I ablation and on Levothyroxine.
| Original language | English |
|---|---|
| Pages (from-to) | 2050-2054 |
| Number of pages | 5 |
| Journal | Research Journal of Pharmacy and Technology |
| Volume | 11 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 01-05-2018 |
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All Science Journal Classification (ASJC) codes
- Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
- Pharmacology (medical)
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Evaluation of covariates using population pharmacokinetics approach for dose individualization of levothyroxine in patients with post thyroidectomy and131i ablation therapy. / Kumar, Rajesh; Prabhu, Mukhyaprana; Pai, Sreedhar R.; Shenoy, Vasudev.
In: Research Journal of Pharmacy and Technology, Vol. 11, No. 5, 01.05.2018, p. 2050-2054.Research output: Contribution to journal › Article
TY - JOUR
T1 - Evaluation of covariates using population pharmacokinetics approach for dose individualization of levothyroxine in patients with post thyroidectomy and131i ablation therapy
AU - Kumar, Rajesh
AU - Prabhu, Mukhyaprana
AU - Pai, Sreedhar R.
AU - Shenoy, Vasudev
PY - 2018/5/1
Y1 - 2018/5/1
N2 - The current therapy for patients with thyroid cancer is total or near to total thyroidectomy with Radio Iodine treatment. Subsequent to the thyroidectomy the patients are on Levothyroxine as a supplement therapy to maintain the Thyroid hormone levels.Levothyroxine has been considered as a narrow therapeutic index drug. In Thyroid cancer patients, radio-iodine ablation procedure causes hypothyroid state which will be further elongated by the administration of sub optimal doses and hyperthyroid symptoms with higher doses. The current study was conducted to evaluate the covariates influencing the drug concentration of levothyroxine in our target population, i.e Patient with Papillary carcinoma, undergone total thyroidectomy followed by131I ablation and on Levothyroxine.
AB - The current therapy for patients with thyroid cancer is total or near to total thyroidectomy with Radio Iodine treatment. Subsequent to the thyroidectomy the patients are on Levothyroxine as a supplement therapy to maintain the Thyroid hormone levels.Levothyroxine has been considered as a narrow therapeutic index drug. In Thyroid cancer patients, radio-iodine ablation procedure causes hypothyroid state which will be further elongated by the administration of sub optimal doses and hyperthyroid symptoms with higher doses. The current study was conducted to evaluate the covariates influencing the drug concentration of levothyroxine in our target population, i.e Patient with Papillary carcinoma, undergone total thyroidectomy followed by131I ablation and on Levothyroxine.
UR - http://www.scopus.com/inward/record.url?scp=85050927762&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85050927762&partnerID=8YFLogxK
U2 - 10.5958/0974-360X.2018.00380.3
DO - 10.5958/0974-360X.2018.00380.3
M3 - Article
VL - 11
SP - 2050
EP - 2054
JO - Research Journal of Pharmacy and Technology
JF - Research Journal of Pharmacy and Technology
SN - 0974-3618
IS - 5
ER -