Evaluation of diuretic activity of Amaranthus spinosus Linn. aqueous extract in Wistar rats

Arul Amuthan, Bharti Chogtu, K. L. Bairy, Sudhakar, Mungli Prakash

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15 Citations (Scopus)

Abstract

Ethnopharmacological relevance: Traditional Siddha medicine literature claims that the Amaranthus spinosus Linn. (family: Amaranthaceae) whole plant possesses diuretic property. Aim of the study: To evaluate the diuretic potential of Amaranthus spinosus aqueous extract (ASAE) in rats. Material and methods: Different concentrations of ASAE (200, 500, 1000, 1500 mg/kg), thiazide (10 mg/kg) and vehicle were orally administered to rats (n = 6 animals per group) and their urine output was collected after 24 h. Volume, pH, Na +, K + and Cl - concentrations of urine were estimated. Results: ASAE produced increase in Na +, K +, Cl - excretion, caused alkalinization of urine, showed strong saluretic activity and carbonic anhydrase inhibition activity. These effects were observed predominantly at 500 mg/kg dose and there was no dose-response relationship. Conclusion: Our study strongly suggests that the Amaranthus spinosus is acting as a thiazide like diuretic with carbonic anhydrase inhibitory activity which restates the claim as diuretic herb in Siddha medicine.

Original languageEnglish
Pages (from-to)424-427
Number of pages4
JournalJournal of Ethnopharmacology
Volume140
Issue number2
DOIs
Publication statusPublished - 27-03-2012

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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