Evaluation of diuretic activity of Amaranthus spinosus Linn. aqueous extract in Wistar rats

Arul Amuthan, Bharti Chogtu, K. L. Bairy, Sudhakar, Mungli Prakash

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Ethnopharmacological relevance: Traditional Siddha medicine literature claims that the Amaranthus spinosus Linn. (family: Amaranthaceae) whole plant possesses diuretic property. Aim of the study: To evaluate the diuretic potential of Amaranthus spinosus aqueous extract (ASAE) in rats. Material and methods: Different concentrations of ASAE (200, 500, 1000, 1500 mg/kg), thiazide (10 mg/kg) and vehicle were orally administered to rats (n = 6 animals per group) and their urine output was collected after 24 h. Volume, pH, Na +, K + and Cl - concentrations of urine were estimated. Results: ASAE produced increase in Na +, K +, Cl - excretion, caused alkalinization of urine, showed strong saluretic activity and carbonic anhydrase inhibition activity. These effects were observed predominantly at 500 mg/kg dose and there was no dose-response relationship. Conclusion: Our study strongly suggests that the Amaranthus spinosus is acting as a thiazide like diuretic with carbonic anhydrase inhibitory activity which restates the claim as diuretic herb in Siddha medicine.

Original languageEnglish
Pages (from-to)424-427
Number of pages4
JournalJournal of Ethnopharmacology
Volume140
Issue number2
DOIs
Publication statusPublished - 27-03-2012

Fingerprint

Amaranthus
Diuretics
Wistar Rats
Ayurvedic Medicine
Carbonic Anhydrases
Urine
Amaranthaceae
Thiazides
Sodium Chloride Symporter Inhibitors
Traditional Medicine

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

@article{c5a19ed2be204e3798e55829789db09b,
title = "Evaluation of diuretic activity of Amaranthus spinosus Linn. aqueous extract in Wistar rats",
abstract = "Ethnopharmacological relevance: Traditional Siddha medicine literature claims that the Amaranthus spinosus Linn. (family: Amaranthaceae) whole plant possesses diuretic property. Aim of the study: To evaluate the diuretic potential of Amaranthus spinosus aqueous extract (ASAE) in rats. Material and methods: Different concentrations of ASAE (200, 500, 1000, 1500 mg/kg), thiazide (10 mg/kg) and vehicle were orally administered to rats (n = 6 animals per group) and their urine output was collected after 24 h. Volume, pH, Na +, K + and Cl - concentrations of urine were estimated. Results: ASAE produced increase in Na +, K +, Cl - excretion, caused alkalinization of urine, showed strong saluretic activity and carbonic anhydrase inhibition activity. These effects were observed predominantly at 500 mg/kg dose and there was no dose-response relationship. Conclusion: Our study strongly suggests that the Amaranthus spinosus is acting as a thiazide like diuretic with carbonic anhydrase inhibitory activity which restates the claim as diuretic herb in Siddha medicine.",
author = "Arul Amuthan and Bharti Chogtu and Bairy, {K. L.} and Sudhakar and Mungli Prakash",
year = "2012",
month = "3",
day = "27",
doi = "10.1016/j.jep.2012.01.049",
language = "English",
volume = "140",
pages = "424--427",
journal = "Journal of Ethnopharmacology",
issn = "0378-8741",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

Evaluation of diuretic activity of Amaranthus spinosus Linn. aqueous extract in Wistar rats. / Amuthan, Arul; Chogtu, Bharti; Bairy, K. L.; Sudhakar; Prakash, Mungli.

In: Journal of Ethnopharmacology, Vol. 140, No. 2, 27.03.2012, p. 424-427.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of diuretic activity of Amaranthus spinosus Linn. aqueous extract in Wistar rats

AU - Amuthan, Arul

AU - Chogtu, Bharti

AU - Bairy, K. L.

AU - Sudhakar,

AU - Prakash, Mungli

PY - 2012/3/27

Y1 - 2012/3/27

N2 - Ethnopharmacological relevance: Traditional Siddha medicine literature claims that the Amaranthus spinosus Linn. (family: Amaranthaceae) whole plant possesses diuretic property. Aim of the study: To evaluate the diuretic potential of Amaranthus spinosus aqueous extract (ASAE) in rats. Material and methods: Different concentrations of ASAE (200, 500, 1000, 1500 mg/kg), thiazide (10 mg/kg) and vehicle were orally administered to rats (n = 6 animals per group) and their urine output was collected after 24 h. Volume, pH, Na +, K + and Cl - concentrations of urine were estimated. Results: ASAE produced increase in Na +, K +, Cl - excretion, caused alkalinization of urine, showed strong saluretic activity and carbonic anhydrase inhibition activity. These effects were observed predominantly at 500 mg/kg dose and there was no dose-response relationship. Conclusion: Our study strongly suggests that the Amaranthus spinosus is acting as a thiazide like diuretic with carbonic anhydrase inhibitory activity which restates the claim as diuretic herb in Siddha medicine.

AB - Ethnopharmacological relevance: Traditional Siddha medicine literature claims that the Amaranthus spinosus Linn. (family: Amaranthaceae) whole plant possesses diuretic property. Aim of the study: To evaluate the diuretic potential of Amaranthus spinosus aqueous extract (ASAE) in rats. Material and methods: Different concentrations of ASAE (200, 500, 1000, 1500 mg/kg), thiazide (10 mg/kg) and vehicle were orally administered to rats (n = 6 animals per group) and their urine output was collected after 24 h. Volume, pH, Na +, K + and Cl - concentrations of urine were estimated. Results: ASAE produced increase in Na +, K +, Cl - excretion, caused alkalinization of urine, showed strong saluretic activity and carbonic anhydrase inhibition activity. These effects were observed predominantly at 500 mg/kg dose and there was no dose-response relationship. Conclusion: Our study strongly suggests that the Amaranthus spinosus is acting as a thiazide like diuretic with carbonic anhydrase inhibitory activity which restates the claim as diuretic herb in Siddha medicine.

UR - http://www.scopus.com/inward/record.url?scp=84858003016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858003016&partnerID=8YFLogxK

U2 - 10.1016/j.jep.2012.01.049

DO - 10.1016/j.jep.2012.01.049

M3 - Article

VL - 140

SP - 424

EP - 427

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

SN - 0378-8741

IS - 2

ER -