Evaluation of flavonoid fraction of Trigonella foenumgraecum for its wound healing potential

A.T. Sudheendra, R. Shenoy, A.D. Taranalli

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Wound healing potential of Trigonella foenum- graecum (TFG) was evaluated in the present study. The study was done on rodents using incision, excision and dead space wound models. The flavonoid fraction of TFG seed enhanced the breaking strength of incision wounds significantly at 200 mg/kg and 500 mg/kg (p<0.01) as compared to control. At both the dose levels, TFG fraction showed significant reduction in the wound area in the excision wound model. Dry granuloma weight and granuloma tissue breaking strength were increased significantly by TFG. Histopathological reports of the granulation tissue of the treated groups showed better healing when compared to control. These results indicated the pro-healing effect of flavonoid fraction of TFG seed.
Original languageEnglish
Pages (from-to)1154-1162
Number of pages9
JournalPharmacologyonline
Volume1
Publication statusPublished - 2009

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Trigonella
Flavonoids
Wound Healing
Wounds and Injuries
Granuloma
Seeds
Space Simulation
Granulation Tissue
Rodentia
Weights and Measures

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title = "Evaluation of flavonoid fraction of Trigonella foenumgraecum for its wound healing potential",
abstract = "Wound healing potential of Trigonella foenum- graecum (TFG) was evaluated in the present study. The study was done on rodents using incision, excision and dead space wound models. The flavonoid fraction of TFG seed enhanced the breaking strength of incision wounds significantly at 200 mg/kg and 500 mg/kg (p<0.01) as compared to control. At both the dose levels, TFG fraction showed significant reduction in the wound area in the excision wound model. Dry granuloma weight and granuloma tissue breaking strength were increased significantly by TFG. Histopathological reports of the granulation tissue of the treated groups showed better healing when compared to control. These results indicated the pro-healing effect of flavonoid fraction of TFG seed.",
author = "A.T. Sudheendra and R. Shenoy and A.D. Taranalli",
note = "Export Date: 10 November 2017 Correspondence Address: Sudheendra, A.T.; Dept. of Pharmacology, Manipal College of Pharmaceutical Sciences (MCOPS), Manipal-576 104, India; email: arun.ts@manipal.edu Chemicals/CAS: butanol, 35296-72-1, 71-36-3 References: Cotran, R.S., Kumar, V., Robbins, S.L., (1994) Robbins pathological basis of disease, pp. 85-90. , W. B. Saunders: Philadelphia;; Clark, R.A.F., (1985) J Am Acad Dermatol, 13, pp. 701-725; Laura Shane, W.M.C., (2001) Diabetes Spectrum, 14 (4), pp. 199-207; Kokate, C.K., Purohit, A.P., Gokhale, S.B., (1994) Practical Pharmacognosy, pp. 107-113. , Vallabh Prakashan: New Delhi;; Harborne, J.B., (1998) Phytochemical Methods, pp. 60-66. , Chapman & Hall: London;; Ghosh, M.N., (1984) Fundamentals of experimental Pharmacology, p. 153. , Scientific book agency: Calcutta;; Turner, M.A., (1965) Screening methods in Pharmacology, p. 26. , Academic Press: New York;; Ehrlich, P.H., Hunt, T.K., (1968) Ann Surg, 167, pp. 324-328; Lee, K.H., (1968) J. Pharm Sci, 57, pp. 1042-1043; Morton, J.J., Malone, M.H., (1972) Arch Int Pharmacodyn Ther, 196, pp. 117-126; Patil, P.A., Kulkarni, D.R., (1984) Ind. J. Med. Res, 79, pp. 445-447; Lee, K.H., Tong, T.G., (1970) J. Pharm. Sci, 59, pp. 1195-1197; Woessner, J.F., (1961) Arch Biochem Biophys, 93, pp. 440-447; Dissemond, J., Goos, M., Wagner, S.N., (2002) Hautarzt, 53, pp. 718-723; Dutt, P., Ghaskadbi, S., Mohan, H., Devasagayam, T.P.A., (2005) Phytotherapy research, 19, pp. 977-983",
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Evaluation of flavonoid fraction of Trigonella foenumgraecum for its wound healing potential. / Sudheendra, A.T.; Shenoy, R.; Taranalli, A.D.

In: Pharmacologyonline, Vol. 1, 2009, p. 1154-1162.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of flavonoid fraction of Trigonella foenumgraecum for its wound healing potential

AU - Sudheendra, A.T.

AU - Shenoy, R.

AU - Taranalli, A.D.

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PY - 2009

Y1 - 2009

N2 - Wound healing potential of Trigonella foenum- graecum (TFG) was evaluated in the present study. The study was done on rodents using incision, excision and dead space wound models. The flavonoid fraction of TFG seed enhanced the breaking strength of incision wounds significantly at 200 mg/kg and 500 mg/kg (p<0.01) as compared to control. At both the dose levels, TFG fraction showed significant reduction in the wound area in the excision wound model. Dry granuloma weight and granuloma tissue breaking strength were increased significantly by TFG. Histopathological reports of the granulation tissue of the treated groups showed better healing when compared to control. These results indicated the pro-healing effect of flavonoid fraction of TFG seed.

AB - Wound healing potential of Trigonella foenum- graecum (TFG) was evaluated in the present study. The study was done on rodents using incision, excision and dead space wound models. The flavonoid fraction of TFG seed enhanced the breaking strength of incision wounds significantly at 200 mg/kg and 500 mg/kg (p<0.01) as compared to control. At both the dose levels, TFG fraction showed significant reduction in the wound area in the excision wound model. Dry granuloma weight and granuloma tissue breaking strength were increased significantly by TFG. Histopathological reports of the granulation tissue of the treated groups showed better healing when compared to control. These results indicated the pro-healing effect of flavonoid fraction of TFG seed.

M3 - Article

VL - 1

SP - 1154

EP - 1162

JO - Pharmacologyonline

JF - Pharmacologyonline

SN - 1827-8620

ER -