Evaluation of flavonoid fraction of Trigonella foenumgraecum for its wound healing potential

A.T. Sudheendra, R. Shenoy, A.D. Taranalli

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Abstract

Wound healing potential of Trigonella foenum- graecum (TFG) was evaluated in the present study. The study was done on rodents using incision, excision and dead space wound models. The flavonoid fraction of TFG seed enhanced the breaking strength of incision wounds significantly at 200 mg/kg and 500 mg/kg (p<0.01) as compared to control. At both the dose levels, TFG fraction showed significant reduction in the wound area in the excision wound model. Dry granuloma weight and granuloma tissue breaking strength were increased significantly by TFG. Histopathological reports of the granulation tissue of the treated groups showed better healing when compared to control. These results indicated the pro-healing effect of flavonoid fraction of TFG seed.
Original languageEnglish
Pages (from-to)1154-1162
Number of pages9
JournalPharmacologyonline
Volume1
Publication statusPublished - 2009

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