Evaluation of gastroprotective effect of coenzyme q 10 and l-glutamine in stress and ethanol-induced peptic ulcer in wistar rats: A novel preclinical study

Balaji Ommurugan, Shalini Adiga, Vijetha Shenoy Belle

Research output: Contribution to journalArticle

Abstract

Objective: Coenzyme Q 10 (CoQ10) and L-glutamine have antioxidant property their role in peptic ulcer diseases is not well known. Hence, the aim of present study is to evaluate the gastroprotective role of CoQ10 and L-glutamine in stress and ethanol-induced peptic ulcers in Wistar albino rats. Methods: A total of 90 rats were used for the conduct of study in two experimental models, the stress-and the ethanol-induced ulcer model. Each model consists of eight groups with six rats in each group. Sucralfate and pantoprazole were used as standard drugs along with CoQ10 and L-glutamine as test drugs. Drugs were administered for 10 days in stress model and 7 days in case of ethanol model. Statistically analyzed using analysis of variance and post-hoc test with significance as p>0.05 Results: CoQ10 and L-glutamine when used alone as well in combination with pantoprazole and sucralfate showed no ulcer formation. Test drugs showed decrease in gastric acid secretion, decreased total and free acidity levels, higher gastric pH, increased mucous secreting ability, higher levels of reduced glutathione levels in both tissue as well as blood and lower malondialdehyde levels when compared with pantoprazole and sucralfate suggestive of their antioxidative benefit, in both the models. Conclusion: Well-designed clinical trials can be done to evaluate the use of CoQ10 and L-glutamine in the treatment of peptic ulcer disease due to various etiology.

Original languageEnglish
Pages (from-to)365-371
Number of pages7
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume11
Issue number9
DOIs
Publication statusPublished - 01-09-2018

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Ubiquinone
Coenzymes
Glutamine
Peptic Ulcer
Wistar Rats
Sucralfate
Ethanol
Pharmaceutical Preparations
Ulcer
Gastric Acid
Malondialdehyde
Glutathione
Stomach
Analysis of Variance
Theoretical Models
Antioxidants
Clinical Trials
pantoprazole

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

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title = "Evaluation of gastroprotective effect of coenzyme q 10 and l-glutamine in stress and ethanol-induced peptic ulcer in wistar rats: A novel preclinical study",
abstract = "Objective: Coenzyme Q 10 (CoQ10) and L-glutamine have antioxidant property their role in peptic ulcer diseases is not well known. Hence, the aim of present study is to evaluate the gastroprotective role of CoQ10 and L-glutamine in stress and ethanol-induced peptic ulcers in Wistar albino rats. Methods: A total of 90 rats were used for the conduct of study in two experimental models, the stress-and the ethanol-induced ulcer model. Each model consists of eight groups with six rats in each group. Sucralfate and pantoprazole were used as standard drugs along with CoQ10 and L-glutamine as test drugs. Drugs were administered for 10 days in stress model and 7 days in case of ethanol model. Statistically analyzed using analysis of variance and post-hoc test with significance as p>0.05 Results: CoQ10 and L-glutamine when used alone as well in combination with pantoprazole and sucralfate showed no ulcer formation. Test drugs showed decrease in gastric acid secretion, decreased total and free acidity levels, higher gastric pH, increased mucous secreting ability, higher levels of reduced glutathione levels in both tissue as well as blood and lower malondialdehyde levels when compared with pantoprazole and sucralfate suggestive of their antioxidative benefit, in both the models. Conclusion: Well-designed clinical trials can be done to evaluate the use of CoQ10 and L-glutamine in the treatment of peptic ulcer disease due to various etiology.",
author = "Balaji Ommurugan and Shalini Adiga and Belle, {Vijetha Shenoy}",
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T1 - Evaluation of gastroprotective effect of coenzyme q 10 and l-glutamine in stress and ethanol-induced peptic ulcer in wistar rats

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AU - Adiga, Shalini

AU - Belle, Vijetha Shenoy

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N2 - Objective: Coenzyme Q 10 (CoQ10) and L-glutamine have antioxidant property their role in peptic ulcer diseases is not well known. Hence, the aim of present study is to evaluate the gastroprotective role of CoQ10 and L-glutamine in stress and ethanol-induced peptic ulcers in Wistar albino rats. Methods: A total of 90 rats were used for the conduct of study in two experimental models, the stress-and the ethanol-induced ulcer model. Each model consists of eight groups with six rats in each group. Sucralfate and pantoprazole were used as standard drugs along with CoQ10 and L-glutamine as test drugs. Drugs were administered for 10 days in stress model and 7 days in case of ethanol model. Statistically analyzed using analysis of variance and post-hoc test with significance as p>0.05 Results: CoQ10 and L-glutamine when used alone as well in combination with pantoprazole and sucralfate showed no ulcer formation. Test drugs showed decrease in gastric acid secretion, decreased total and free acidity levels, higher gastric pH, increased mucous secreting ability, higher levels of reduced glutathione levels in both tissue as well as blood and lower malondialdehyde levels when compared with pantoprazole and sucralfate suggestive of their antioxidative benefit, in both the models. Conclusion: Well-designed clinical trials can be done to evaluate the use of CoQ10 and L-glutamine in the treatment of peptic ulcer disease due to various etiology.

AB - Objective: Coenzyme Q 10 (CoQ10) and L-glutamine have antioxidant property their role in peptic ulcer diseases is not well known. Hence, the aim of present study is to evaluate the gastroprotective role of CoQ10 and L-glutamine in stress and ethanol-induced peptic ulcers in Wistar albino rats. Methods: A total of 90 rats were used for the conduct of study in two experimental models, the stress-and the ethanol-induced ulcer model. Each model consists of eight groups with six rats in each group. Sucralfate and pantoprazole were used as standard drugs along with CoQ10 and L-glutamine as test drugs. Drugs were administered for 10 days in stress model and 7 days in case of ethanol model. Statistically analyzed using analysis of variance and post-hoc test with significance as p>0.05 Results: CoQ10 and L-glutamine when used alone as well in combination with pantoprazole and sucralfate showed no ulcer formation. Test drugs showed decrease in gastric acid secretion, decreased total and free acidity levels, higher gastric pH, increased mucous secreting ability, higher levels of reduced glutathione levels in both tissue as well as blood and lower malondialdehyde levels when compared with pantoprazole and sucralfate suggestive of their antioxidative benefit, in both the models. Conclusion: Well-designed clinical trials can be done to evaluate the use of CoQ10 and L-glutamine in the treatment of peptic ulcer disease due to various etiology.

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