Evaluation of hepatoprotective activity of Ginkgo biloba in rats

K. Ashok Shenoy, S. N. Somayaji, K. L. Bairy

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36 Citations (Scopus)

Abstract

The mechanism of hepatoprotective effects of Ginkgo biloba (GB), an herbal preparation with wide variety of therapeutic application, on paracetamol (Pcml) induced hepatic damage in rats has been ivestigated. GB treatment restored the marker enzyme levels indicating the in vivo protective effects against Pcml induced liver damage both in preventive and curative aspects. GB also rversed the increased TBARS levels, and elevated the GSH content of the liver. The results obtained from the study indicate hepatoprotective nature of GB, which might be due to its ability to prevent lipid peroxidation and replenishing the gllutathione level. The effects of GB were comparable to that of silymarin.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalIndian Journal of Physiology and Pharmacology
Volume46
Issue number2
Publication statusPublished - 01-01-2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

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    Ashok Shenoy, K., Somayaji, S. N., & Bairy, K. L. (2002). Evaluation of hepatoprotective activity of Ginkgo biloba in rats. Indian Journal of Physiology and Pharmacology, 46(2), 167-174.