Evaluation of Homonia riparia lour. for antiurolithiatic activity in albino rats

K. V.S.R.G. Prasad, R. Abraham, K. Bharathi, K. K. Srinivasan

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Ethanol extract of the roots of Homonia riparia was tested for its antiurolithiatic activity against calcium oxalate and magnesium ammonium phosphate stones in male albino rats. Calcium oxalate stones were induced by feeding 3% glycolic acid along with normal feed and magnesium ammonium phosphate stones were induced by implantation of zinc discs in the urinary bladder. The ethanol extract of H. riparia (2 g/kg/day, orally) was found to be effective in reducing deposition of calcium in the kidney of both prophylactic and curative group animals. The extract did not show any significant effect on the activity of the liver enzyme glycolic acid oxidase and on the deposition of oxalate in the kidney. The extract was found to be effective in reducing the formation and also in dissolving the pre-formed magnesium ammonium phosphate type of stones.

Original languageEnglish
Pages (from-to)278-283
Number of pages6
JournalPharmaceutical Biology
Volume35
Issue number4
DOIs
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

Calcium Oxalate
glycolic acid
Ethanol
Kidney
Oxalates
Zinc
Urinary Bladder
Calcium
Liver
Enzymes
Struvite
glycollate oxidase

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

Cite this

Prasad, K. V. S. R. G., Abraham, R., Bharathi, K., & Srinivasan, K. K. (1997). Evaluation of Homonia riparia lour. for antiurolithiatic activity in albino rats. Pharmaceutical Biology, 35(4), 278-283. https://doi.org/10.1076/phbi.35.4.278.13309
Prasad, K. V.S.R.G. ; Abraham, R. ; Bharathi, K. ; Srinivasan, K. K. / Evaluation of Homonia riparia lour. for antiurolithiatic activity in albino rats. In: Pharmaceutical Biology. 1997 ; Vol. 35, No. 4. pp. 278-283.
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Prasad, KVSRG, Abraham, R, Bharathi, K & Srinivasan, KK 1997, 'Evaluation of Homonia riparia lour. for antiurolithiatic activity in albino rats', Pharmaceutical Biology, vol. 35, no. 4, pp. 278-283. https://doi.org/10.1076/phbi.35.4.278.13309

Evaluation of Homonia riparia lour. for antiurolithiatic activity in albino rats. / Prasad, K. V.S.R.G.; Abraham, R.; Bharathi, K.; Srinivasan, K. K.

In: Pharmaceutical Biology, Vol. 35, No. 4, 1997, p. 278-283.

Research output: Contribution to journalReview article

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T1 - Evaluation of Homonia riparia lour. for antiurolithiatic activity in albino rats

AU - Prasad, K. V.S.R.G.

AU - Abraham, R.

AU - Bharathi, K.

AU - Srinivasan, K. K.

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AB - Ethanol extract of the roots of Homonia riparia was tested for its antiurolithiatic activity against calcium oxalate and magnesium ammonium phosphate stones in male albino rats. Calcium oxalate stones were induced by feeding 3% glycolic acid along with normal feed and magnesium ammonium phosphate stones were induced by implantation of zinc discs in the urinary bladder. The ethanol extract of H. riparia (2 g/kg/day, orally) was found to be effective in reducing deposition of calcium in the kidney of both prophylactic and curative group animals. The extract did not show any significant effect on the activity of the liver enzyme glycolic acid oxidase and on the deposition of oxalate in the kidney. The extract was found to be effective in reducing the formation and also in dissolving the pre-formed magnesium ammonium phosphate type of stones.

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