Evaluation of hypoglycemic effects of 4-thiazolidinones

J.M. Joy, N. Jacob, G.N. Kutty

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Nicotinic acid, a well-known hypolipidemic drug, is known to produce elevation of blood glucose in humans. In an earlier study in our laboratory, a thiazolidinone derivative of nicotinic acid was shown to exert hypolipidemic effect. The present study was aimed to find out if this compound produced any elevation of blood glucose in normal and diabetic Wistar rats. A closely related thiazolidinone was also evaluated. The two compounds reduced blood glucose in both normal and diabetic rats, while nicotinic acid produced hyperglycemia. The thiazolidinone structure with its hypoglycemic potential may be opposing the glucose elevating effect of nicotinoyl moiety. It is concluded from the study that the thiazolidinone derivative of nicotinic acid is a hypoglycemic agent besides being hypolipidemic. Detailed investigation is warranted.
Original languageEnglish
Pages (from-to)17-21
Number of pages5
JournalIndian Drugs
Volume42
Issue number1
Publication statusPublished - 2005

Fingerprint

Niacin
Hypoglycemic Agents
Blood Glucose
Hypolipidemic Agents
Hyperglycemia
Wistar Rats
Glucose

Cite this

Joy, J. M., Jacob, N., & Kutty, G. N. (2005). Evaluation of hypoglycemic effects of 4-thiazolidinones. Indian Drugs, 42(1), 17-21.
Joy, J.M. ; Jacob, N. ; Kutty, G.N. / Evaluation of hypoglycemic effects of 4-thiazolidinones. In: Indian Drugs. 2005 ; Vol. 42, No. 1. pp. 17-21.
@article{070eda35e6074ba3b63a388198588621,
title = "Evaluation of hypoglycemic effects of 4-thiazolidinones",
abstract = "Nicotinic acid, a well-known hypolipidemic drug, is known to produce elevation of blood glucose in humans. In an earlier study in our laboratory, a thiazolidinone derivative of nicotinic acid was shown to exert hypolipidemic effect. The present study was aimed to find out if this compound produced any elevation of blood glucose in normal and diabetic Wistar rats. A closely related thiazolidinone was also evaluated. The two compounds reduced blood glucose in both normal and diabetic rats, while nicotinic acid produced hyperglycemia. The thiazolidinone structure with its hypoglycemic potential may be opposing the glucose elevating effect of nicotinoyl moiety. It is concluded from the study that the thiazolidinone derivative of nicotinic acid is a hypoglycemic agent besides being hypolipidemic. Detailed investigation is warranted.",
author = "J.M. Joy and N. Jacob and G.N. Kutty",
note = "Cited By :5 Export Date: 10 November 2017 CODEN: INDRB Correspondence Address: Kutty, G. N.; Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India; email: ngopu20in@yahoo.com References: Vega, G.L., Grundy, S.M., Lipoprotein responses to treatment with lovastatin, gemfibrozil and nicotinic acid in normolipidemic patients with hypoalpha-lipoproteinemia (1994) Arch. Intern. Med, 154, pp. 73-82; Carlson, L.A., Hamsten, A., Asplund, A., Pronounced lowering of serum levels of lipoproteinLp (a) in hyperlipidemic subjects treated with nicotinic acid (1989) J. Intern. Med, 226, pp. 271-276; Mahley, R.W., Bersot, T.P., Drug therapy for hypercholesterolemia and dyslipidemia (2001) Goodman and Gilman's the Pharmacological Basis of Therapeutics, pp. 971-1002. , Hardman J.G and Limbird L.C (Eds), McGraw Hill Companies Inc, 10 th Ed; Jacob, N., Kutty, G.N., Synthesis and hypolipidemic activity of a thiazolidinone derivative (2004) Indian Drugs, 41 (2), pp. 76-79; Schwartz, M.L., Severe reversible hyperglycemia as a consequence of niacin therapy (1993) Archives of Internal Medicine, 153 (17), pp. 2050-2052. , DOI 10.1001/archinte.153.17.2050; Surrey, A.R., 4-Thiazolidones IV. The preparation of some substituted 3-aminoalkyl-2-aryl derivatives (1949) J. Am. Chem. Soc, 71, pp. 3354-3356; Trinder, P., Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen (1969) J. Clin. Pathol., 22, pp. 158-161; Carroll, N.V., Longley, R.W., Roe, J.H., The determination of glycogen in liver and muscle by use of anthrone reagent (1956) J. Biol. Chem, 220, pp. 583-593; Paget, G.E., Barnes, J.M., (1964) Evaluation of Drug Activities: Pharmacometrics, 1, pp. 135-166. , Laurence D.A. and Bacharach A.L (Eds), Academic Press, New York; Kaneto, H., Kajimoto, Y., Miyagawa, J., Matsuoka, T., Fujitani, Y., Umayahara, Y., Hanafusa, T., Hori, M., Beneficial effects of antioxidants in diabetes: Possible protection of pancreatic beta-cells against glucose toxicity (1999) Diabetes, 48 (12), pp. 2398-2406; Krieger, M., Role of oxidised low-density lipoproteins in atherogenesis (1994) J. Clin. Invest, 88, pp. 1758-1792",
year = "2005",
language = "English",
volume = "42",
pages = "17--21",
journal = "Indian Drugs",
issn = "0019-462X",
publisher = "Indian Drug Manufacturers' Association",
number = "1",

}

Joy, JM, Jacob, N & Kutty, GN 2005, 'Evaluation of hypoglycemic effects of 4-thiazolidinones', Indian Drugs, vol. 42, no. 1, pp. 17-21.

Evaluation of hypoglycemic effects of 4-thiazolidinones. / Joy, J.M.; Jacob, N.; Kutty, G.N.

In: Indian Drugs, Vol. 42, No. 1, 2005, p. 17-21.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of hypoglycemic effects of 4-thiazolidinones

AU - Joy, J.M.

AU - Jacob, N.

AU - Kutty, G.N.

N1 - Cited By :5 Export Date: 10 November 2017 CODEN: INDRB Correspondence Address: Kutty, G. N.; Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India; email: ngopu20in@yahoo.com References: Vega, G.L., Grundy, S.M., Lipoprotein responses to treatment with lovastatin, gemfibrozil and nicotinic acid in normolipidemic patients with hypoalpha-lipoproteinemia (1994) Arch. Intern. Med, 154, pp. 73-82; Carlson, L.A., Hamsten, A., Asplund, A., Pronounced lowering of serum levels of lipoproteinLp (a) in hyperlipidemic subjects treated with nicotinic acid (1989) J. Intern. Med, 226, pp. 271-276; Mahley, R.W., Bersot, T.P., Drug therapy for hypercholesterolemia and dyslipidemia (2001) Goodman and Gilman's the Pharmacological Basis of Therapeutics, pp. 971-1002. , Hardman J.G and Limbird L.C (Eds), McGraw Hill Companies Inc, 10 th Ed; Jacob, N., Kutty, G.N., Synthesis and hypolipidemic activity of a thiazolidinone derivative (2004) Indian Drugs, 41 (2), pp. 76-79; Schwartz, M.L., Severe reversible hyperglycemia as a consequence of niacin therapy (1993) Archives of Internal Medicine, 153 (17), pp. 2050-2052. , DOI 10.1001/archinte.153.17.2050; Surrey, A.R., 4-Thiazolidones IV. The preparation of some substituted 3-aminoalkyl-2-aryl derivatives (1949) J. Am. Chem. Soc, 71, pp. 3354-3356; Trinder, P., Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen (1969) J. Clin. Pathol., 22, pp. 158-161; Carroll, N.V., Longley, R.W., Roe, J.H., The determination of glycogen in liver and muscle by use of anthrone reagent (1956) J. Biol. Chem, 220, pp. 583-593; Paget, G.E., Barnes, J.M., (1964) Evaluation of Drug Activities: Pharmacometrics, 1, pp. 135-166. , Laurence D.A. and Bacharach A.L (Eds), Academic Press, New York; Kaneto, H., Kajimoto, Y., Miyagawa, J., Matsuoka, T., Fujitani, Y., Umayahara, Y., Hanafusa, T., Hori, M., Beneficial effects of antioxidants in diabetes: Possible protection of pancreatic beta-cells against glucose toxicity (1999) Diabetes, 48 (12), pp. 2398-2406; Krieger, M., Role of oxidised low-density lipoproteins in atherogenesis (1994) J. Clin. Invest, 88, pp. 1758-1792

PY - 2005

Y1 - 2005

N2 - Nicotinic acid, a well-known hypolipidemic drug, is known to produce elevation of blood glucose in humans. In an earlier study in our laboratory, a thiazolidinone derivative of nicotinic acid was shown to exert hypolipidemic effect. The present study was aimed to find out if this compound produced any elevation of blood glucose in normal and diabetic Wistar rats. A closely related thiazolidinone was also evaluated. The two compounds reduced blood glucose in both normal and diabetic rats, while nicotinic acid produced hyperglycemia. The thiazolidinone structure with its hypoglycemic potential may be opposing the glucose elevating effect of nicotinoyl moiety. It is concluded from the study that the thiazolidinone derivative of nicotinic acid is a hypoglycemic agent besides being hypolipidemic. Detailed investigation is warranted.

AB - Nicotinic acid, a well-known hypolipidemic drug, is known to produce elevation of blood glucose in humans. In an earlier study in our laboratory, a thiazolidinone derivative of nicotinic acid was shown to exert hypolipidemic effect. The present study was aimed to find out if this compound produced any elevation of blood glucose in normal and diabetic Wistar rats. A closely related thiazolidinone was also evaluated. The two compounds reduced blood glucose in both normal and diabetic rats, while nicotinic acid produced hyperglycemia. The thiazolidinone structure with its hypoglycemic potential may be opposing the glucose elevating effect of nicotinoyl moiety. It is concluded from the study that the thiazolidinone derivative of nicotinic acid is a hypoglycemic agent besides being hypolipidemic. Detailed investigation is warranted.

M3 - Article

VL - 42

SP - 17

EP - 21

JO - Indian Drugs

JF - Indian Drugs

SN - 0019-462X

IS - 1

ER -

Joy JM, Jacob N, Kutty GN. Evaluation of hypoglycemic effects of 4-thiazolidinones. Indian Drugs. 2005;42(1):17-21.